| Item type |
学術雑誌論文 / Journal Article(1) |
| タイトル |
|
|
タイトル |
Short Term Outcome of Total Neoadjuvant Therapy with Modified Short Course Chemoradiation Therapy and Consolidation Sox Chemotherapy for Locally Advanced Rectal Cancer |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Locally advanced rectal cancer |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Total neoadjuvant therapy |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Short-course treatment outcomes |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
Ihara, Keisuke
Nakamura, Takatoshi
Takayanagi, Masashi
Kono, Takahiro
Nishi, Yusuke
Nemoto, Tetsutaro
Shibuya, Norisuke
Hachiya, Hiroyuki
Ishizuka, Mitsuru
Ishida, Kazuyuki
Ejima, Yasuo
Mizushima, Tsunekazu
|
| 書誌情報 |
en : Dokkyo Medical Journal
巻 4,
号 6,
p. 437-446,
発行日 2025-12-25
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| 記事種別 |
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|
値 |
Original |
| 内容記述 |
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|
内容記述タイプ |
Abstract |
|
内容記述 |
Background: The aim of this phase II single-arm clinical trial was to evaluate the safety and efficacy of a total neoadjuvant therapy (TNT) regimen consisting of systemic SOX chemotherapy (S-1 and oxaliplatin) during the waiting period after modified short course chemoradiation therapy (mSCCRT) for preoperative treatment of patients with cStage II/III rectal cancer.
Materials and Methods: The study targeted 34 patients with lower rectal cancer cStage II/III treated with TNT between April 2021 and April 2024. The TNT protocol consisted of mSCCRT, radiation therapy 30 Gy (3 Gy × 10 fractions) concurrently with S-1 (80 mg/day, administered on days 1-5 and days 7-11), followed by two cycles of consolidation chemotherapy using SOX (S-1: 80 mg/body, oxaliplatin: 130 mg/body). A total mesorectal excision with lymph node dissection was performed 8-10 weeks after radiation therapy. The safety and efficacy of this treatment were evaluated.
Results: The patients were 27 men and 7 women. A total of 30 patients (88.2%) completed the entire treatment regimen. The most common adverse event was diarrhea, observed in 23 cases (67.6%). Among these, 3 cases (8.8%) were classified as CTCAE Grade 3, with the remainder being Grade 1. Postoperative complications included one case (3.3%) of intra-abdominal abscess classified as Clavien-Dindo Grade IIIa. The pathological complete response (pCR) rate was 31.3%.
Conclusion: The TNT regimen combining mSCCRT and consolidation chemotherapy was feasible and safe, with minimal severe adverse effects and postoperative complications, and was oncologically effective. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Dokkyo Medical Society |
| ISSN |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
2436-522X |
| 書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12941861 |
| DOI |
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|
関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.51040/dkmj.2025-010 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
DKMJ-4-6-2.pdf (151 KB)
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