{"_buckets": {"deposit": "e77b0058-fcb9-45fb-ad46-424a11e06198"}, "_deposit": {"created_by": 3, "id": "214", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "214"}, "status": "published"}, "_oai": {"id": "oai:dmu.repo.nii.ac.jp:00000214", "sets": ["29"]}, "author_link": ["745", "747", "741", "746", "742", "743", "744"], "item_2_biblio_info_12": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2004-03-25", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "26", "bibliographicPageStart": "17", "bibliographicVolumeNumber": "31", "bibliographic_titles": [{"bibliographic_title": "Dokkyo journal of medical sciences"}]}]}, "item_2_description_11": {"attribute_name": "抄録(英)", "attribute_value_mlt": [{"subitem_description": "Transforming growth factor-β (TGF-β) is a profibrogenic cytokine that is involved in airway remodeling largely associated with chronic asthma. Accordingly, regulators of TGF-β activity could also play some role in airway remodeling in asthma. In this study, we investigated expression of Smad 7, a major intracellular inhibitor of TGF-β signaling, in the airways of mouse models of acute and chronic asthma. Sensitized, repeatedly (14 days) ovalbumin (OVA)-inhaled BALB/c mice exhibited evidence of airway remodeling including prominent subepithelial fibrosis associated with airway hyperresponsiveness (AHR) and airway inflammation (chronic asthma model) whereas sensitized, shortly OVA-inhaled BALB/c mice showed only AHR and airway inflammation (acute asthma model). Immunohistochemical analysis showed that Smad 7 immunoreactivity in the airways was increased after the development of acute and chronic asthma models and mainly detected in bronchial epithelial cells. Interestingly, Smad 7 immunoreactivity was significantly less in the airways of chronic asthma model than in those of acute asthma model, which was also confirmed by real-time PCR analysis of Smad 7. In consistent with decreased Smad 7 expression in the airways of chronic asthma model, phosphorylation of Smad 2, a marker of active TGF-β signaling, was increased in bronchial epithelial cells of chronic asthma model when compared with acute asthma model. These results suggest that decreased Smad 7 expression and Smad 2 upregulation in bronchial epithelial cells might result in increased TGF-β activity and contribute to the development of airway remodeling seen in chronic asthma.", "subitem_description_type": "Other"}]}, "item_2_description_15": {"attribute_name": "表示順", "attribute_value_mlt": [{"subitem_description": "5", "subitem_description_type": "Other"}]}, "item_2_description_16": {"attribute_name": "アクセション番号", "attribute_value_mlt": [{"subitem_description": "KJ00004091307", "subitem_description_type": "Other"}]}, "item_2_description_8": {"attribute_name": "記事種別(日)", "attribute_value_mlt": [{"subitem_description": "原著", "subitem_description_type": "Other"}]}, "item_2_description_9": {"attribute_name": "記事種別(英)", "attribute_value_mlt": [{"subitem_description": "Original", "subitem_description_type": "Other"}]}, "item_2_source_id_1": {"attribute_name": "雑誌書誌ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00629581", "subitem_source_identifier_type": "NCID"}]}, "item_2_source_id_19": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "03855023", "subitem_source_identifier_type": "ISSN"}]}, "item_2_text_7": {"attribute_name": "著者所属(英)", "attribute_value_mlt": [{"subitem_text_language": "en", "subitem_text_value": "Department of Pulmonary Medicine and Clinical Immunology, Dokkyo University School of Medicine"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Parasitology and Immunology, University ofYamanashi Faculty of Medicine"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Pulmonary Medicine and Clinical Immunology, Dokkyo University School of Medicine"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Pulmonary Medicine and Clinical Immunology, Dokkyo University School of Medicine"}, {"subitem_text_language": "en", "subitem_text_value": "Laboratory of Molecular and Cellular Biology, Dokkyo University School of Medicine"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Pulmonary Medicine and Clinical Immunology, Dokkyo University School of Medicine"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Pulmonary Medicine and Clinical Immunology, Dokkyo University School of Medicine"}]}, "item_2_title_3": {"attribute_name": "論文名よみ", "attribute_value_mlt": [{"subitem_title": "Airway Expression of Smad7, a TGF-β-inducible Inhibitory Molecule of TGF-β Signaling, Decreases after Repeated Airway Antigen Challenges"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Ota, Mayumi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "741", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakao, Atsuhito", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "742", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sugiyama, Kumiya", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "743", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Cheng, Gang", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "744", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Akimoto, Kazumi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "745", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Okada, Takenori", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "746", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sagara, Hironori", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "747", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-05-24"}], "displaytype": "detail", 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"attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Airway Expression of Smad7, a TGF-β-inducible Inhibitory Molecule of TGF-β Signaling, Decreases after Repeated Airway Antigen Challenges", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Airway Expression of Smad7, a TGF-β-inducible Inhibitory Molecule of TGF-β Signaling, Decreases after Repeated Airway Antigen Challenges", "subitem_title_language": "en"}]}, "item_type_id": "2", "owner": "3", "path": ["29"], "permalink_uri": "https://dmu.repo.nii.ac.jp/records/214", "pubdate": {"attribute_name": "公開日", "attribute_value": "2017-05-24"}, "publish_date": "2017-05-24", "publish_status": "0", "recid": "214", "relation": {}, "relation_version_is_last": true, "title": ["Airway Expression of Smad7, a TGF-β-inducible 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