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Airway Expression of Smad7, a TGF-β-inducible Inhibitory Molecule of TGF-β Signaling, Decreases after Repeated Airway Antigen Challenges
https://dmu.repo.nii.ac.jp/records/214
https://dmu.repo.nii.ac.jp/records/214631d9d07-5752-428b-a4b5-31974a6e0f85
名前 / ファイル | ライセンス | アクション |
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Item type | [ELS]学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-05-24 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Airway Expression of Smad7, a TGF-β-inducible Inhibitory Molecule of TGF-β Signaling, Decreases after Repeated Airway Antigen Challenges | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題 | Smad 7 | |||||
キーワード | ||||||
言語 | en | |||||
主題 | chronic asthma | |||||
キーワード | ||||||
言語 | en | |||||
主題 | bronchial epithelial cells | |||||
キーワード | ||||||
言語 | en | |||||
主題 | airway remodeling | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
雑誌書誌ID | ||||||
収録物識別子 | AA00629581 | |||||
論文名よみ | ||||||
タイトル | Airway Expression of Smad7, a TGF-β-inducible Inhibitory Molecule of TGF-β Signaling, Decreases after Repeated Airway Antigen Challenges | |||||
著者 |
Ota, Mayumi
× Ota, Mayumi× Nakao, Atsuhito× Sugiyama, Kumiya× Cheng, Gang× Akimoto, Kazumi× Okada, Takenori× Sagara, Hironori |
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著者所属(英) | ||||||
en | ||||||
Department of Pulmonary Medicine and Clinical Immunology, Dokkyo University School of Medicine | ||||||
著者所属(英) | ||||||
en | ||||||
Department of Parasitology and Immunology, University ofYamanashi Faculty of Medicine | ||||||
著者所属(英) | ||||||
en | ||||||
Department of Pulmonary Medicine and Clinical Immunology, Dokkyo University School of Medicine | ||||||
著者所属(英) | ||||||
en | ||||||
Department of Pulmonary Medicine and Clinical Immunology, Dokkyo University School of Medicine | ||||||
著者所属(英) | ||||||
en | ||||||
Laboratory of Molecular and Cellular Biology, Dokkyo University School of Medicine | ||||||
著者所属(英) | ||||||
en | ||||||
Department of Pulmonary Medicine and Clinical Immunology, Dokkyo University School of Medicine | ||||||
著者所属(英) | ||||||
en | ||||||
Department of Pulmonary Medicine and Clinical Immunology, Dokkyo University School of Medicine | ||||||
記事種別(日) | ||||||
内容記述タイプ | Other | |||||
内容記述 | 原著 | |||||
記事種別(英) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Original | |||||
抄録(英) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Transforming growth factor-β (TGF-β) is a profibrogenic cytokine that is involved in airway remodeling largely associated with chronic asthma. Accordingly, regulators of TGF-β activity could also play some role in airway remodeling in asthma. In this study, we investigated expression of Smad 7, a major intracellular inhibitor of TGF-β signaling, in the airways of mouse models of acute and chronic asthma. Sensitized, repeatedly (14 days) ovalbumin (OVA)-inhaled BALB/c mice exhibited evidence of airway remodeling including prominent subepithelial fibrosis associated with airway hyperresponsiveness (AHR) and airway inflammation (chronic asthma model) whereas sensitized, shortly OVA-inhaled BALB/c mice showed only AHR and airway inflammation (acute asthma model). Immunohistochemical analysis showed that Smad 7 immunoreactivity in the airways was increased after the development of acute and chronic asthma models and mainly detected in bronchial epithelial cells. Interestingly, Smad 7 immunoreactivity was significantly less in the airways of chronic asthma model than in those of acute asthma model, which was also confirmed by real-time PCR analysis of Smad 7. In consistent with decreased Smad 7 expression in the airways of chronic asthma model, phosphorylation of Smad 2, a marker of active TGF-β signaling, was increased in bronchial epithelial cells of chronic asthma model when compared with acute asthma model. These results suggest that decreased Smad 7 expression and Smad 2 upregulation in bronchial epithelial cells might result in increased TGF-β activity and contribute to the development of airway remodeling seen in chronic asthma. | |||||
書誌情報 |
Dokkyo journal of medical sciences 巻 31, 号 1, p. 17-26, 発行日 2004-03-25 |
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ISSN | ||||||
収録物識別子 | 03855023 |