| Item type |
[ELS]学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-05-24 |
| タイトル |
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タイトル |
Airway Expression of Smad7, a TGF-β-inducible Inhibitory Molecule of TGF-β Signaling, Decreases after Repeated Airway Antigen Challenges |
|
言語 |
en |
| 言語 |
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|
言語 |
eng |
| キーワード |
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言語 |
en |
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主題 |
Smad 7 |
| キーワード |
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|
言語 |
en |
|
主題 |
chronic asthma |
| キーワード |
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|
言語 |
en |
|
主題 |
bronchial epithelial cells |
| キーワード |
|
|
言語 |
en |
|
主題 |
airway remodeling |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 雑誌書誌ID |
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収録物識別子 |
AA00629581 |
| 論文名よみ |
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タイトル |
Airway Expression of Smad7, a TGF-β-inducible Inhibitory Molecule of TGF-β Signaling, Decreases after Repeated Airway Antigen Challenges |
| 著者 |
Ota, Mayumi
Nakao, Atsuhito
Sugiyama, Kumiya
Cheng, Gang
Akimoto, Kazumi
Okada, Takenori
Sagara, Hironori
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| 著者所属(英) |
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en |
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Department of Pulmonary Medicine and Clinical Immunology, Dokkyo University School of Medicine |
| 著者所属(英) |
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en |
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Department of Parasitology and Immunology, University ofYamanashi Faculty of Medicine |
| 著者所属(英) |
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en |
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Department of Pulmonary Medicine and Clinical Immunology, Dokkyo University School of Medicine |
| 著者所属(英) |
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en |
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Department of Pulmonary Medicine and Clinical Immunology, Dokkyo University School of Medicine |
| 著者所属(英) |
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en |
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Laboratory of Molecular and Cellular Biology, Dokkyo University School of Medicine |
| 著者所属(英) |
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en |
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Department of Pulmonary Medicine and Clinical Immunology, Dokkyo University School of Medicine |
| 著者所属(英) |
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en |
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Department of Pulmonary Medicine and Clinical Immunology, Dokkyo University School of Medicine |
| 記事種別(日) |
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内容記述タイプ |
Other |
|
内容記述 |
原著 |
| 記事種別(英) |
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内容記述タイプ |
Other |
|
内容記述 |
Original |
| 抄録(英) |
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内容記述タイプ |
Other |
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内容記述 |
Transforming growth factor-β (TGF-β) is a profibrogenic cytokine that is involved in airway remodeling largely associated with chronic asthma. Accordingly, regulators of TGF-β activity could also play some role in airway remodeling in asthma. In this study, we investigated expression of Smad 7, a major intracellular inhibitor of TGF-β signaling, in the airways of mouse models of acute and chronic asthma. Sensitized, repeatedly (14 days) ovalbumin (OVA)-inhaled BALB/c mice exhibited evidence of airway remodeling including prominent subepithelial fibrosis associated with airway hyperresponsiveness (AHR) and airway inflammation (chronic asthma model) whereas sensitized, shortly OVA-inhaled BALB/c mice showed only AHR and airway inflammation (acute asthma model). Immunohistochemical analysis showed that Smad 7 immunoreactivity in the airways was increased after the development of acute and chronic asthma models and mainly detected in bronchial epithelial cells. Interestingly, Smad 7 immunoreactivity was significantly less in the airways of chronic asthma model than in those of acute asthma model, which was also confirmed by real-time PCR analysis of Smad 7. In consistent with decreased Smad 7 expression in the airways of chronic asthma model, phosphorylation of Smad 2, a marker of active TGF-β signaling, was increased in bronchial epithelial cells of chronic asthma model when compared with acute asthma model. These results suggest that decreased Smad 7 expression and Smad 2 upregulation in bronchial epithelial cells might result in increased TGF-β activity and contribute to the development of airway remodeling seen in chronic asthma. |
| 書誌情報 |
Dokkyo journal of medical sciences
巻 31,
号 1,
p. 17-26,
発行日 2004-03-25
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
03855023 |
KJ00004091307.pdf (851.3 kB)
