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Therapeutic Effects of a Sodium Glucose Cotransporter 2 Inhibitor in Diabetic Patients with Chronic Kidney Disease
https://dmu.repo.nii.ac.jp/records/2187
https://dmu.repo.nii.ac.jp/records/2187a1689754-c0d1-4818-9a06-6a5814994e4e
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
DJMS-46-2-Onoda-本文 (198.4 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| タイトル | ||||||
| タイトル | Therapeutic Effects of a Sodium Glucose Cotransporter 2 Inhibitor in Diabetic Patients with Chronic Kidney Disease | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | sodium glucose cotransporter 2 inhibitors | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | ipragliflozin, | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | diabetes mellitus, chronic kidney disease, blood pressure | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Onoda, Shou
× Onoda, Shou× Ishimitsu, Toshihiko× Uematsu, Mayu× Hirao, Jun× Abe , Makoto× Ishimitsu, Akira× Kaiga, Akiko× Satonaka, Hiroshi |
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| 著者所属(英) | ||||||
| 言語 | en | |||||
| 値 | Department of Nephrology and Hypertension, Dokkyo Medical University, Mibu, Tochigi, Japan | |||||
| 著者所属(英) | ||||||
| 言語 | en | |||||
| 値 | Department of Nephrology and Hypertension, Dokkyo Medical University, Mibu, Tochigi, Japan | |||||
| 著者所属(英) | ||||||
| 言語 | en | |||||
| 値 | Department of Nephrology and Hypertension, Dokkyo Medical University, Mibu, Tochigi, Japan | |||||
| 著者所属(英) | ||||||
| 言語 | en | |||||
| 値 | Department of Nephrology and Hypertension, Dokkyo Medical University, Mibu, Tochigi, Japan | |||||
| 著者所属(英) | ||||||
| 言語 | en | |||||
| 値 | Department of Nephrology and Hypertension, Dokkyo Medical University, Mibu, Tochigi, Japan | |||||
| 著者所属(英) | ||||||
| 言語 | en | |||||
| 値 | Department of Nephrology and Hypertension, Dokkyo Medical University, Mibu, Tochigi, Japan | |||||
| 著者所属(英) | ||||||
| 言語 | en | |||||
| 値 | Department of Nephrology and Hypertension, Dokkyo Medical University, Mibu, Tochigi, Japan | |||||
| 著者所属(英) | ||||||
| 言語 | en | |||||
| 値 | Department of Nephrology and Hypertension, Dokkyo Medical University, Mibu, Tochigi, Japan | |||||
| 書誌情報 |
Dokkyo Journal of Medical Sciences 巻 46, 号 2, p. 45-54, 発行日 2019-07-25 |
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| 要旨(英) | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Multiple large-scale clinical trials have indicated that sodium glucose cotransporter 2（SGLT2）inhibitors reduce the incidence of cardiovascular events, deterioration of renal function and mortality. However, the therapeutic effects of SGLT2 inhibitors are supposed to be limited in patients with reduced renal function considering the mechanism of their action. In this study, a SGLT2 inhibitor, ipragliflozin was given to 30 type 2 diabetic patients with nephropathy whose estimated glomerular filtration rate（eGFR）was not lower than 30 mL/min/1.73 m2. After 12 to 16 weeks, hemoglobin A1c decreased by 0.6％（p＜0.001）, body weight was reduced by 1.8 kg（p＜0.01）and blood pressure was lowered by －10/－6 mmHg（p＜0.001/p ＜0.001）. This was accompanied by reductions in serum uric acid（－0.7 mg/dL, p＜0.001）, triglycerides （－25 mg/dL, p＝0.028）and g-glutamyl transferase（－8 U/L, p＝0.001）. On the other hand, plasma B-type natriuretic peptide also decreased by 12％（p＝0.020）and urinary albumin excretion was reduced by 23％ （p＝0.018）although the eGFR was not significantly changed. It is concluded that ipragliflozin is effective in lowering blood glucose even in patients with diabetic kidney disease and is beneficial in improving the accompanying obesity and hypertension. In addition, ipragliflozin is thought to have favorable influences on the metabolisms of uric acid and lipids. These properties of ipragliflozin is expected to bring about protective effects against the progression of nephropathy and the development of cardiovascular disease resulting in the improvement of prognosis in diabetic patients with mild to moderate chronic kidney disease. |
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| 記事種別 | ||||||
| 値 | Original | |||||
| 出版者 | ||||||
| 出版者 | 獨協医学会 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 03855023 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00629581 | |||||
