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Roles of FoxP3-positive Regulatory T Cells in Lymphoid Follicle Formation Associated with Lung Squamous Cell Carcinoma
https://dmu.repo.nii.ac.jp/records/2292
https://dmu.repo.nii.ac.jp/records/22925be0f5ed-3629-46fa-8021-f22135731db9
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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タイトル | ||||||
タイトル | Roles of FoxP3-positive Regulatory T Cells in Lymphoid Follicle Formation Associated with Lung Squamous Cell Carcinoma | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | lung cancer | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | squamous cell carcinoma | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | regulatory T cell | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | lymphoid follicle | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Nishihira, Morimichi
× Nishihira, Morimichi× Nakazato, Yoshimasa× Wakamatsu, Ikuma× Maeda, Sumiko× Inoue, Takashi× Araki, Osamu× Karube, Yoko× Chida, Masayuki |
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著者所属(英) | ||||||
en | ||||||
Departments of General Thoracic Surgery, Dokkyo Medical University, Mibu, Tochigi, Japan | ||||||
著者所属(英) | ||||||
en | ||||||
Departments of Diagnostic Pathology, Dokkyo Medical University, Mibu, Tochigi, Japan | ||||||
著者所属(英) | ||||||
en | ||||||
Departments of General Thoracic Surgery, Dokkyo Medical University, Mibu, Tochigi, Japan | ||||||
著者所属(英) | ||||||
en | ||||||
Departments of General Thoracic Surgery, Dokkyo Medical University, Mibu, Tochigi, Japan | ||||||
著者所属(英) | ||||||
en | ||||||
Departments of General Thoracic Surgery, Dokkyo Medical University, Mibu, Tochigi, Japan | ||||||
著者所属(英) | ||||||
en | ||||||
Departments of General Thoracic Surgery, Dokkyo Medical University, Mibu, Tochigi, Japan | ||||||
著者所属(英) | ||||||
en | ||||||
Departments of General Thoracic Surgery, Dokkyo Medical University, Mibu, Tochigi, Japan | ||||||
著者所属(英) | ||||||
en | ||||||
Departments of General Thoracic Surgery, Dokkyo Medical University, Mibu, Tochigi, Japan | ||||||
書誌情報 |
Dokkyo Journal of Medical Sciences 巻 47, 号 1, p. 9-13, 発行日 2020-03-25 |
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要旨(英) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Background:We previously reported that lymphoid follicle formation by tumor infiltrating lymphocytes(TILs)is a negative predictor of prognosis in patients with lung squamous cell carcinoma(SCC)following surgery. However, the roles of FoxP3⁺/CD4⁺/CD25⁺-regulatory T cells(Tregs)in formation of lymphoid follicles as well as survival remain unclear. Methods:Specimens obtained from patients during resection of lung SCC were examined for lymphoid follicle formation and subjected to immunohistochemistry analysis for the presence of TILs. Results:The appearance of Tregs was correlated with lymphoid follicle formation(p=0.001). Univariate analysis also showed that Tregs tended to be correlated with overall survival(p=0.097), whereas multivariate analysis revealed that lymphoid follicle formation(p=0.042)and pleural invasion(p=0.031)were independent prognostic factors related to overall survival, while the appearance of Tregs was not. Conclusion:Treg appearance was correlated with lymphoid follicle formation. That lymphoid follicle formation, rather than appearance of Tregs, is a predictor of patients survival following surgery for lung SCC. |
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記事種別 | ||||||
Original | ||||||
出版者 | ||||||
出版者 | 獨協医学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 03855023 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00629581 | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://id.nii.ac.jp/1199/00002393/ | |||||
関連名称 | Correction |