Item type |
学術雑誌論文 / Journal Article(1) |
タイトル |
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タイトル |
Roles of FoxP3-positive Regulatory T Cells in Lymphoid Follicle Formation Associated with Lung Squamous Cell Carcinoma |
言語 |
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言語 |
eng |
キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
lung cancer |
キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
squamous cell carcinoma |
キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
regulatory T cell |
キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
lymphoid follicle |
資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
著者 |
Nishihira, Morimichi
Nakazato, Yoshimasa
Wakamatsu, Ikuma
Maeda, Sumiko
Inoue, Takashi
Araki, Osamu
Karube, Yoko
Chida, Masayuki
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著者所属(英) |
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en |
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Departments of General Thoracic Surgery, Dokkyo Medical University, Mibu, Tochigi, Japan |
著者所属(英) |
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en |
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Departments of Diagnostic Pathology, Dokkyo Medical University, Mibu, Tochigi, Japan |
著者所属(英) |
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en |
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Departments of General Thoracic Surgery, Dokkyo Medical University, Mibu, Tochigi, Japan |
著者所属(英) |
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en |
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Departments of General Thoracic Surgery, Dokkyo Medical University, Mibu, Tochigi, Japan |
著者所属(英) |
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en |
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Departments of General Thoracic Surgery, Dokkyo Medical University, Mibu, Tochigi, Japan |
著者所属(英) |
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en |
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Departments of General Thoracic Surgery, Dokkyo Medical University, Mibu, Tochigi, Japan |
著者所属(英) |
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en |
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Departments of General Thoracic Surgery, Dokkyo Medical University, Mibu, Tochigi, Japan |
著者所属(英) |
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en |
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Departments of General Thoracic Surgery, Dokkyo Medical University, Mibu, Tochigi, Japan |
書誌情報 |
Dokkyo Journal of Medical Sciences
巻 47,
号 1,
p. 9-13,
発行日 2020-03-25
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要旨(英) |
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内容記述タイプ |
Other |
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内容記述 |
Background:We previously reported that lymphoid follicle formation by tumor infiltrating lymphocytes(TILs)is a negative predictor of prognosis in patients with lung squamous cell carcinoma(SCC)following surgery. However, the roles of FoxP3⁺/CD4⁺/CD25⁺-regulatory T cells(Tregs)in formation of lymphoid follicles as well as survival remain unclear. Methods:Specimens obtained from patients during resection of lung SCC were examined for lymphoid follicle formation and subjected to immunohistochemistry analysis for the presence of TILs. Results:The appearance of Tregs was correlated with lymphoid follicle formation(p=0.001). Univariate analysis also showed that Tregs tended to be correlated with overall survival(p=0.097), whereas multivariate analysis revealed that lymphoid follicle formation(p=0.042)and pleural invasion(p=0.031)were independent prognostic factors related to overall survival, while the appearance of Tregs was not. Conclusion:Treg appearance was correlated with lymphoid follicle formation. That lymphoid follicle formation, rather than appearance of Tregs, is a predictor of patients survival following surgery for lung SCC. |
記事種別 |
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Original |
出版者 |
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出版者 |
獨協医学会 |
ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
03855023 |
書誌レコードID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA00629581 |
関連サイト |
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識別子タイプ |
URI |
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関連識別子 |
http://id.nii.ac.jp/1199/00002393/ |
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関連名称 |
Correction |