| Item type |
学術雑誌論文 / Journal Article(1) |
| タイトル |
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|
タイトル |
Roles of FoxP3-positive Regulatory T Cells in Lymphoid Follicle Formation Associated with Lung Squamous Cell Carcinoma |
| 言語 |
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|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
lung cancer |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
squamous cell carcinoma |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
regulatory T cell |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
lymphoid follicle |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Nishihira, Morimichi
Nakazato, Yoshimasa
Wakamatsu, Ikuma
Maeda, Sumiko
Inoue, Takashi
Araki, Osamu
Karube, Yoko
Chida, Masayuki
|
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Departments of General Thoracic Surgery, Dokkyo Medical University, Mibu, Tochigi, Japan |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Departments of Diagnostic Pathology, Dokkyo Medical University, Mibu, Tochigi, Japan |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Departments of General Thoracic Surgery, Dokkyo Medical University, Mibu, Tochigi, Japan |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Departments of General Thoracic Surgery, Dokkyo Medical University, Mibu, Tochigi, Japan |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Departments of General Thoracic Surgery, Dokkyo Medical University, Mibu, Tochigi, Japan |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Departments of General Thoracic Surgery, Dokkyo Medical University, Mibu, Tochigi, Japan |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Departments of General Thoracic Surgery, Dokkyo Medical University, Mibu, Tochigi, Japan |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Departments of General Thoracic Surgery, Dokkyo Medical University, Mibu, Tochigi, Japan |
| 書誌情報 |
Dokkyo Journal of Medical Sciences
巻 47,
号 1,
p. 9-13,
発行日 2020-03-25
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| 要旨(英) |
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内容記述タイプ |
Other |
|
内容記述 |
Background：We previously reported that lymphoid follicle formation by tumor infiltrating lymphocytes（TILs）is a negative predictor of prognosis in patients with lung squamous cell carcinoma（SCC）following surgery. However, the roles of FoxP3⁺/CD4⁺/CD25⁺-regulatory T cells（Tregs）in formation of lymphoid follicles as well as survival remain unclear.
Methods：Specimens obtained from patients during resection of lung SCC were examined for lymphoid follicle formation and subjected to immunohistochemistry analysis for the presence of TILs.
Results：The appearance of Tregs was correlated with lymphoid follicle formation（p＝0.001）. Univariate analysis also showed that Tregs tended to be correlated with overall survival（p＝0.097）, whereas multivariate analysis revealed that lymphoid follicle formation（p＝0.042）and pleural invasion（p＝0.031）were independent prognostic factors related to overall survival, while the appearance of Tregs was not.
Conclusion：Treg appearance was correlated with lymphoid follicle formation. That lymphoid follicle formation, rather than appearance of Tregs, is a predictor of patients survival following surgery for lung SCC. |
| 記事種別 |
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値 |
Original |
| 出版者 |
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出版者 |
獨協医学会 |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
03855023 |
| 書誌レコードID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00629581 |
| 関連サイト |
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識別子タイプ |
URI |
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関連識別子 |
http://id.nii.ac.jp/1199/00002393/ |
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関連名称 |
Correction |
DJMS-47-1-Nishihira-本文 (181.7 kB)
