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  1. Dokkyo Journal of Medical Sciences
  2. 47(1) 2020

Roles of FoxP3-positive Regulatory T Cells in Lymphoid Follicle Formation Associated with Lung Squamous Cell Carcinoma

https://dmu.repo.nii.ac.jp/records/2292
https://dmu.repo.nii.ac.jp/records/2292
5be0f5ed-3629-46fa-8021-f22135731db9
名前 / ファイル ライセンス アクション
DJMS-47-1-3.pdf DJMS-47-1-Nishihira-本文 (181.7 kB)
Item type 学術雑誌論文 / Journal Article(1)
タイトル
タイトル Roles of FoxP3-positive Regulatory T Cells in Lymphoid Follicle Formation Associated with Lung Squamous Cell Carcinoma
言語
言語 eng
キーワード
言語 en
主題Scheme Other
主題 lung cancer
キーワード
言語 en
主題Scheme Other
主題 squamous cell carcinoma
キーワード
言語 en
主題Scheme Other
主題 regulatory T cell
キーワード
言語 en
主題Scheme Other
主題 lymphoid follicle
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
著者 Nishihira, Morimichi

× Nishihira, Morimichi

WEKO 10464

en Nishihira, Morimichi

Search repository
Nakazato, Yoshimasa

× Nakazato, Yoshimasa

WEKO 10465

en Nakazato, Yoshimasa

Search repository
Wakamatsu, Ikuma

× Wakamatsu, Ikuma

WEKO 10466

en Wakamatsu, Ikuma

Search repository
Maeda, Sumiko

× Maeda, Sumiko

WEKO 10467

en Maeda, Sumiko

Search repository
Inoue, Takashi

× Inoue, Takashi

WEKO 10468

en Inoue, Takashi

Search repository
Araki, Osamu

× Araki, Osamu

WEKO 10469

en Araki, Osamu

Search repository
Karube, Yoko

× Karube, Yoko

WEKO 10470

en Karube, Yoko

Search repository
Chida, Masayuki

× Chida, Masayuki

WEKO 10471

en Chida, Masayuki

Search repository
著者所属(英)
en
Departments of General Thoracic Surgery, Dokkyo Medical University, Mibu, Tochigi, Japan
著者所属(英)
en
Departments of Diagnostic Pathology, Dokkyo Medical University, Mibu, Tochigi, Japan
著者所属(英)
en
Departments of General Thoracic Surgery, Dokkyo Medical University, Mibu, Tochigi, Japan
著者所属(英)
en
Departments of General Thoracic Surgery, Dokkyo Medical University, Mibu, Tochigi, Japan
著者所属(英)
en
Departments of General Thoracic Surgery, Dokkyo Medical University, Mibu, Tochigi, Japan
著者所属(英)
en
Departments of General Thoracic Surgery, Dokkyo Medical University, Mibu, Tochigi, Japan
著者所属(英)
en
Departments of General Thoracic Surgery, Dokkyo Medical University, Mibu, Tochigi, Japan
著者所属(英)
en
Departments of General Thoracic Surgery, Dokkyo Medical University, Mibu, Tochigi, Japan
書誌情報 Dokkyo Journal of Medical Sciences

巻 47, 号 1, p. 9-13, 発行日 2020-03-25
要旨(英)
内容記述タイプ Other
内容記述 Background:We previously reported that lymphoid follicle formation by tumor infiltrating lymphocytes(TILs)is a negative predictor of prognosis in patients with lung squamous cell carcinoma(SCC)following surgery. However, the roles of FoxP3⁺/CD4⁺/CD25⁺-regulatory T cells(Tregs)in formation of lymphoid follicles as well as survival remain unclear.
Methods:Specimens obtained from patients during resection of lung SCC were examined for lymphoid follicle formation and subjected to immunohistochemistry analysis for the presence of TILs.
Results:The appearance of Tregs was correlated with lymphoid follicle formation(p=0.001). Univariate analysis also showed that Tregs tended to be correlated with overall survival(p=0.097), whereas multivariate analysis revealed that lymphoid follicle formation(p=0.042)and pleural invasion(p=0.031)were independent prognostic factors related to overall survival, while the appearance of Tregs was not.
Conclusion:Treg appearance was correlated with lymphoid follicle formation. That lymphoid follicle formation, rather than appearance of Tregs, is a predictor of patients survival following surgery for lung SCC.
記事種別
Original
出版者
出版者 獨協医学会
ISSN
収録物識別子タイプ ISSN
収録物識別子 03855023
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00629581
関連サイト
識別子タイプ URI
関連識別子 http://id.nii.ac.jp/1199/00002393/
関連名称 Correction
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