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Treatment with Both Nintedanib and Steroid in Bleomycin-induced Pulmonary Fibrosis Model Mice didn’t Inhibit Lung Fibrosis
https://dmu.repo.nii.ac.jp/records/2501
https://dmu.repo.nii.ac.jp/records/25012c648f69-8706-4c8f-acbf-b31c91e0c7af
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
DJMS-48-1-Shiromori-本文 (2.5 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| タイトル | ||||||||||||||||||
| タイトル | Treatment with Both Nintedanib and Steroid in Bleomycin-induced Pulmonary Fibrosis Model Mice didn’t Inhibit Lung Fibrosis | |||||||||||||||||
| 言語 | ||||||||||||||||||
| 言語 | eng | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||
| 主題 | nintedanib | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||
| 主題 | steroid | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||
| 主題 | bleomycin-induced pulmonary fibrosis | |||||||||||||||||
| 資源タイプ | ||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||
| 著者 |
Shiromori, Sadaaki
× Shiromori, Sadaaki
× Hirata, Hirokuni
× Sato, Kozo
× Tada, Kazuhiro
× Arima, Masafumi
× Fukushima, Yasutsugu
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| 著者所属(英) | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| 値 | Department of Respiratory Medicine and Clinical Immunology, Dokkyo Medical University Saitama Medical Center, 2-1-50 Minamikoshigaya, Koshigaya, Saitama 343-0845, Japan | |||||||||||||||||
| 著者所属(英) | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| 値 | Department of Respiratory Medicine and Clinical Immunology, Dokkyo Medical University Saitama Medical Center, 2-1-50 Minamikoshigaya, Koshigaya, Saitama 343-0845, Japan | |||||||||||||||||
| 著者所属(英) | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| 値 | Department of Respiratory Medicine and Clinical Immunology, Dokkyo Medical University Saitama Medical Center, 2-1-50 Minamikoshigaya, Koshigaya, Saitama 343-0845, Japan | |||||||||||||||||
| 著者所属(英) | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| 値 | Department of Respiratory Medicine and Clinical Immunology, Dokkyo Medical University Saitama Medical Center, 2-1-50 Minamikoshigaya, Koshigaya, Saitama 343-0845, Japan | |||||||||||||||||
| 著者所属(英) | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| 値 | Department of Rheumatology, Dokkyo Medical University, Tochigi, Japan. | |||||||||||||||||
| 著者所属(英) | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| 値 | Department of Respiratory Medicine and Clinical Immunology, Dokkyo Medical University Saitama Medical Center, 2-1-50 Minamikoshigaya, Koshigaya, Saitama 343-0845, Japan | |||||||||||||||||
| 書誌情報 |
Dokkyo Journal of Medical Sciences 巻 48, 号 1, p. 9-21, 発行日 2021-03-25 |
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| 要旨(英) | ||||||||||||||||||
| 内容記述タイプ | Other | |||||||||||||||||
| 内容記述 | Background：In the clinical setting, the optimal timing of administration of nintedanib in the active or inactive phase of idiopathic pulmonary fibrosis （IPF） has not been clarified. Also, no consideration has been made of synergistic actions with steroids. Objectives：We used bleomycin-induced pulmonary fibrosis model mice to analyze the effects of the timing of nintedanib administration and synergistic actions in combination with steroids. Method：In the bleomycin-induced pulmonary fibrosis mouse model, nintedanib was given before or after bleomycin administration and the effects on pulmonary fibrosis and fibroblast growth factors in bronchoalveolar lavage （BAL） fluid were analyzed. Then, treatment with both steroid and nintedanib was administered in the same model and the effects of combined use on lung fibrosis were analyzed. Severity of lung fibrosis was analyzed using the Ashcroft score. Fibroblast growth factors in BAL fluid were measured using Magnetic Luminex® assay and enzyme-linked immunosorbent assay. Results：Pretreatment with nintedanib before administration of bleomycin, but not after administration of bleomycin, reduced the Ashcroft score （2.4±1.4 vs 4.9±1.3, P＜0.01） and decreased TGF-b 1 in BAL fluid （95.7±48.4 pg/mL vs 147.1±11.7 pg/mL, P＜0.05）. Conversely, pretreatment with both steroid and nintedanib did not decrease the Ashcroft score compared with pretreatment of saline as a control（ Score：3.8±1.3 vs 4.6±1.1）. There was also no synergistic effect of both steroid and nintedanib on pulmonary fibrosis. Conclusions：Nintedanib may be useful when administered early in patients with IPF. Further more, clinical administration of combined nintedanib and steroid requires caution in view of the effects on pulmonary fibrosis and side effects. |
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| 記事種別 | ||||||||||||||||||
| 値 | Original | |||||||||||||||||
| 出版者 | ||||||||||||||||||
| 出版者 | 獨協医学会 | |||||||||||||||||
| ISSN | ||||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||||
| 収録物識別子 | 03855023 | |||||||||||||||||
| 書誌レコードID | ||||||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||||||
| 収録物識別子 | AA00629581 | |||||||||||||||||
