| Item type |
学術雑誌論文 / Journal Article(1) |
| タイトル |
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|
タイトル |
Pre and Post Synaptic Mechanisms about the Peripheral Nerve-injured Plasticity of Nociceptive Transmission in the Superficial Dorsal Horn of Mouse Spinal Cord |
| 言語 |
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|
言語 |
eng |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
neuropathic pain |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
|
主題 |
central sensitization |
| キーワード |
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言語 |
en |
|
主題Scheme |
Other |
|
主題 |
neuroplasticity |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
long-term potentiation |
| キーワード |
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言語 |
en |
|
主題Scheme |
Other |
|
主題 |
long-term depression |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Sato, Yuya
Aijima, Takaaki
Takasusuki, Toshifumi
Kato, Eiko
Hori, Yuuichi
Yamaguchi, Shigeki
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| 著者所属(英) |
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言語 |
en |
|
値 |
Departments of Anesthesiology, Dokkyo Medical University School of Medicine |
| 著者所属(英) |
|
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言語 |
en |
|
値 |
Departments of Anesthesiology, Dokkyo Medical University School of Medicine |
| 著者所属(英) |
|
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言語 |
en |
|
値 |
Departments of Anesthesiology, Dokkyo Medical University School of Medicine |
| 著者所属(英) |
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言語 |
en |
|
値 |
Departments of Physiology, Dokkyo Medical University School of Medicine |
| 著者所属(英) |
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言語 |
en |
|
値 |
Departments of Physiology, Dokkyo Medical University School of Medicine |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Departments of Anesthesiology, Dokkyo Medical University School of Medicine |
| 書誌情報 |
Dokkyo Journal of Medical Sciences
巻 48,
号 1,
p. 23-31,
発行日 2021-03-25
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| 要旨(英) |
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内容記述タイプ |
Other |
|
内容記述 |
Long-term potentiation（LTP）and long-term depression（LTD）in synaptic transmission have not only been observed in the hippocampus, but also in the superficial dorsal horn. LTP and LTD in the superficial dorsal horn play an important role of central sensitization, leading to hyperalgesia and allodynia in neuropathic pain. In order to clarify its mechanisms, we evaluated evoked excitatory postsynaptic currents（eEPSCs）and asynchronous EPSCs（aEPSCs）in the superficial dorsal horn of a sciatic nerve-ligated neuropathic pain mice（nerve-ligated mice）using whole cell patch clamp recording.
Three types of neuron in the superficial dorsal horn of mouse spinal cord were observed after tetanus stimulation which were：eEPSC amplitude-increased（LTP neuron）, decreased（LTD neuron）and unchanged neurons. After tetanus stimulation, cumulative probability of aEPSCs amplitude did not change in LTP neuron, but shifted to the left in LTD neuron. In nerve-ligated mice, the ratio of LTP neuron was high. On the other hand, the ratio of both LTD neuron and unchanged neuron was high in sham-operated control mice.
These findings suggest both pre- and post-synaptic mechanisms of central sensitization in the superficial dorsal horn may contribute to neuropathic pain and LTP or LTD may be important role of pre- or postsynaptic action, respectively. |
| 記事種別 |
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値 |
Original |
| 出版者 |
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出版者 |
獨協医学会 |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
03855023 |
| 書誌レコードID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA00629581 |
DJMS-48-1-Sato-本文 (584.3 kB)
