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  1. Dokkyo Journal of Medical Sciences
  2. 48(1) 2021

Pre and Post Synaptic Mechanisms about the Peripheral Nerve-injured Plasticity of Nociceptive Transmission in the Superficial Dorsal Horn of Mouse Spinal Cord

https://dmu.repo.nii.ac.jp/records/2502
https://dmu.repo.nii.ac.jp/records/2502
73fc0d0c-73d8-4300-ba2b-5361dc123c9a
名前 / ファイル ライセンス アクション
DJMS-48-1-4.pdf DJMS-48-1-Sato-本文 (584.3 kB)
Item type 学術雑誌論文 / Journal Article(1)
タイトル
タイトル Pre and Post Synaptic Mechanisms about the Peripheral Nerve-injured Plasticity of Nociceptive Transmission in the Superficial Dorsal Horn of Mouse Spinal Cord
言語
言語 eng
キーワード
言語 en
主題Scheme Other
主題 neuropathic pain
キーワード
言語 en
主題Scheme Other
主題 central sensitization
キーワード
言語 en
主題Scheme Other
主題 neuroplasticity
キーワード
言語 en
主題Scheme Other
主題 long-term potentiation
キーワード
言語 en
主題Scheme Other
主題 long-term depression
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
著者 Sato, Yuya

× Sato, Yuya

en Sato, Yuya

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Aijima, Takaaki

× Aijima, Takaaki

en Aijima, Takaaki

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Takasusuki, Toshifumi

× Takasusuki, Toshifumi

en Takasusuki, Toshifumi

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Kato, Eiko

× Kato, Eiko

en Kato, Eiko

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Hori, Yuuichi

× Hori, Yuuichi

en Hori, Yuuichi

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Yamaguchi, Shigeki

× Yamaguchi, Shigeki

en Yamaguchi, Shigeki

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著者所属(英)
言語 en
値 Departments of Anesthesiology, Dokkyo Medical University School of Medicine
著者所属(英)
言語 en
値 Departments of Anesthesiology, Dokkyo Medical University School of Medicine
著者所属(英)
言語 en
値 Departments of Anesthesiology, Dokkyo Medical University School of Medicine
著者所属(英)
言語 en
値 Departments of Physiology, Dokkyo Medical University School of Medicine
著者所属(英)
言語 en
値 Departments of Physiology, Dokkyo Medical University School of Medicine
著者所属(英)
言語 en
値 Departments of Anesthesiology, Dokkyo Medical University School of Medicine
書誌情報 Dokkyo Journal of Medical Sciences

巻 48, 号 1, p. 23-31, 発行日 2021-03-25
要旨(英)
内容記述タイプ Other
内容記述 Long-term potentiation(LTP)and long-term depression(LTD)in synaptic transmission have not only been observed in the hippocampus, but also in the superficial dorsal horn. LTP and LTD in the superficial dorsal horn play an important role of central sensitization, leading to hyperalgesia and allodynia in neuropathic pain. In order to clarify its mechanisms, we evaluated evoked excitatory postsynaptic currents(eEPSCs)and asynchronous EPSCs(aEPSCs)in the superficial dorsal horn of a sciatic nerve-ligated neuropathic pain mice(nerve-ligated mice)using whole cell patch clamp recording.
Three types of neuron in the superficial dorsal horn of mouse spinal cord were observed after tetanus stimulation which were:eEPSC amplitude-increased(LTP neuron), decreased(LTD neuron)and unchanged neurons. After tetanus stimulation, cumulative probability of aEPSCs amplitude did not change in LTP neuron, but shifted to the left in LTD neuron. In nerve-ligated mice, the ratio of LTP neuron was high. On the other hand, the ratio of both LTD neuron and unchanged neuron was high in sham-operated control mice.
These findings suggest both pre- and post-synaptic mechanisms of central sensitization in the superficial dorsal horn may contribute to neuropathic pain and LTP or LTD may be important role of pre- or postsynaptic action, respectively.
記事種別
値 Original
出版者
出版者 獨協医学会
ISSN
収録物識別子タイプ ISSN
収録物識別子 03855023
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00629581
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