{"_buckets": {"deposit": "d86193a6-1856-4ec9-bd22-d6be49aea812"}, "_deposit": {"created_by": 3, "id": "419", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "419"}, "status": "published"}, "_oai": {"id": "oai:dmu.repo.nii.ac.jp:00000419", "sets": ["37"]}, "author_link": ["1683", "1680", "1681", "1682", "1684"], "item_2_biblio_info_12": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2006-03-25", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "24", "bibliographicPageStart": "17", "bibliographicVolumeNumber": "33", "bibliographic_titles": [{"bibliographic_title": "Dokkyo journal of medical sciences"}]}]}, "item_2_description_11": {"attribute_name": "抄録(英)", "attribute_value_mlt": [{"subitem_description": "K201 (JTV-519; 4-[-3{1-(4-benzyl) piperidinyl} propionyl]-7-methoxy-2, 3, 4, 5-tetrahydro-1, 4-ben-zothiazepine), is a multi-channel blocker and a ryanodine receptor stabilizer that exhibits strong cardiopro-tective and antiarrhythmic effects. In this study, we examined how intravenous infusion of K201 without an α-agonist prolongs the QT interval in chloralose-anaesthetized rabbits, and whether the maximum dose of K201 given concomitantly induces torsades de pointes. The QT interval was significantly prolonged in the group receiving 6-hour infusion of K201 at 20 μg/kg/min, but the QTc interval was not prolonged (n=5). With infusion of K201 at 0 (vehicle; n=5), 40 (n=6), 100 (n=6), 200 (n=6) and 400 μg/kg/min (n=5), blood pressure and HR were decreased, and prolongation of PQ, QRS complex, QT and QTc intervals occurred dose-dependently. The QTc interval was significantly prolonged from 211.5±11.9 ms of the baseline to 319.9±31.1 ms at a concentration of 400 μg/kg/min, which is the maximum dose of K201, but tors-ades de pointes was not induced at this dose. These results show that K201, which has a suppressive effect on Ca^\u003c2+\u003e leakage from the sarcoplasmic reticulum and an α_1-adrenoceptor-blocking effect, does not induce torsades de pointes, although it causes prolongation of the QT interval.", "subitem_description_type": "Other"}]}, "item_2_description_15": {"attribute_name": "表示順", "attribute_value_mlt": [{"subitem_description": "5", "subitem_description_type": "Other"}]}, "item_2_description_16": {"attribute_name": "アクセション番号", "attribute_value_mlt": [{"subitem_description": "KJ00004451268", "subitem_description_type": "Other"}]}, "item_2_description_8": {"attribute_name": "記事種別(日)", "attribute_value_mlt": [{"subitem_description": "原著", "subitem_description_type": "Other"}]}, "item_2_description_9": {"attribute_name": "記事種別(英)", "attribute_value_mlt": [{"subitem_description": "Original", "subitem_description_type": "Other"}]}, "item_2_source_id_1": {"attribute_name": "雑誌書誌ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00629581", "subitem_source_identifier_type": "NCID"}]}, "item_2_source_id_19": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "03855023", "subitem_source_identifier_type": "ISSN"}]}, "item_2_text_7": {"attribute_name": "著者所属(英)", "attribute_value_mlt": [{"subitem_text_language": "en", "subitem_text_value": "Department of Cardiology and Pneumology, Dokkyo University School of Medicine"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Clinical Laboratory Medicine, Dokkyo University School of Medicine"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Cardiology and Pneumology, Dokkyo University School of Medicine"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Cardiology and Pneumology, Dokkyo University School of Medicine"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Cardiology and Pneumology, Dokkyo University School of Medicine"}]}, "item_2_title_3": {"attribute_name": "論文名よみ", "attribute_value_mlt": [{"subitem_title": "A Novel Cardioprotective Drug, K201 (JTV519), Induces Prolongation of QT and QTc Intervals, but not Torsades de Pointes"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Matsuda, Toshiya", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1680", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Matsuda, Ryuko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1681", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Taguchi, Isao", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1682", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Toyoda, Shigeru", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1683", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kikuchi, Migaku", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1684", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-05-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "KJ00004451268.pdf", "filesize": [{"value": "577.1 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 577100.0, "url": {"label": "KJ00004451268.pdf", "url": "https://dmu.repo.nii.ac.jp/record/419/files/KJ00004451268.pdf"}, "version_id": "417e49cb-f3b8-42e7-bb25-578d2576ad62"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "K201 (JTV-519)", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "QT interval", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "QTc interval", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "torsades de pointes", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "ryanodine receptor", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "A Novel Cardioprotective Drug, K201 (JTV519), Induces Prolongation of QT and QTc Intervals, but not Torsades de Pointes", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "A Novel Cardioprotective Drug, K201 (JTV519), Induces Prolongation of QT and QTc Intervals, but not Torsades de Pointes", "subitem_title_language": "en"}]}, "item_type_id": "2", "owner": "3", "path": ["37"], "permalink_uri": "https://dmu.repo.nii.ac.jp/records/419", "pubdate": {"attribute_name": "公開日", "attribute_value": "2017-05-24"}, "publish_date": "2017-05-24", "publish_status": "0", "recid": "419", "relation": {}, "relation_version_is_last": true, "title": ["A Novel Cardioprotective Drug, K201 (JTV519), Induces Prolongation of QT and QTc Intervals, but not Torsades de Pointes"], "weko_shared_id": 3}