Item type |
[ELS]学術雑誌論文 / Journal Article(1) |
公開日 |
2017-05-24 |
タイトル |
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言語 |
en |
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タイトル |
A Novel Cardioprotective Drug, K201 (JTV519), Induces Prolongation of QT and QTc Intervals, but not Torsades de Pointes |
言語 |
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言語 |
eng |
キーワード |
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言語 |
en |
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主題 |
K201 (JTV-519) |
キーワード |
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言語 |
en |
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主題 |
QT interval |
キーワード |
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言語 |
en |
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主題 |
QTc interval |
キーワード |
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言語 |
en |
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主題 |
torsades de pointes |
キーワード |
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言語 |
en |
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主題 |
ryanodine receptor |
資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
雑誌書誌ID |
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収録物識別子 |
AA00629581 |
論文名よみ |
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タイトル |
A Novel Cardioprotective Drug, K201 (JTV519), Induces Prolongation of QT and QTc Intervals, but not Torsades de Pointes |
著者 |
Matsuda, Toshiya
Matsuda, Ryuko
Taguchi, Isao
Toyoda, Shigeru
Kikuchi, Migaku
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著者所属(英) |
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en |
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Department of Cardiology and Pneumology, Dokkyo University School of Medicine |
著者所属(英) |
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en |
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Department of Clinical Laboratory Medicine, Dokkyo University School of Medicine |
著者所属(英) |
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en |
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Department of Cardiology and Pneumology, Dokkyo University School of Medicine |
著者所属(英) |
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en |
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Department of Cardiology and Pneumology, Dokkyo University School of Medicine |
著者所属(英) |
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en |
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Department of Cardiology and Pneumology, Dokkyo University School of Medicine |
記事種別(日) |
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内容記述タイプ |
Other |
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内容記述 |
原著 |
記事種別(英) |
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内容記述タイプ |
Other |
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内容記述 |
Original |
抄録(英) |
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内容記述タイプ |
Other |
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内容記述 |
K201 (JTV-519; 4-[-3{1-(4-benzyl) piperidinyl} propionyl]-7-methoxy-2, 3, 4, 5-tetrahydro-1, 4-ben-zothiazepine), is a multi-channel blocker and a ryanodine receptor stabilizer that exhibits strong cardiopro-tective and antiarrhythmic effects. In this study, we examined how intravenous infusion of K201 without an α-agonist prolongs the QT interval in chloralose-anaesthetized rabbits, and whether the maximum dose of K201 given concomitantly induces torsades de pointes. The QT interval was significantly prolonged in the group receiving 6-hour infusion of K201 at 20 μg/kg/min, but the QTc interval was not prolonged (n=5). With infusion of K201 at 0 (vehicle; n=5), 40 (n=6), 100 (n=6), 200 (n=6) and 400 μg/kg/min (n=5), blood pressure and HR were decreased, and prolongation of PQ, QRS complex, QT and QTc intervals occurred dose-dependently. The QTc interval was significantly prolonged from 211.5±11.9 ms of the baseline to 319.9±31.1 ms at a concentration of 400 μg/kg/min, which is the maximum dose of K201, but tors-ades de pointes was not induced at this dose. These results show that K201, which has a suppressive effect on Ca^<2+> leakage from the sarcoplasmic reticulum and an α_1-adrenoceptor-blocking effect, does not induce torsades de pointes, although it causes prolongation of the QT interval. |
書誌情報 |
Dokkyo journal of medical sciences
巻 33,
号 1,
p. 17-24,
発行日 2006-03-25
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ISSN |
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収録物識別子 |
03855023 |