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A Novel Cardioprotective Drug, K201 (JTV519), Induces Prolongation of QT and QTc Intervals, but not Torsades de Pointes
https://dmu.repo.nii.ac.jp/records/419
https://dmu.repo.nii.ac.jp/records/419cbb0160e-a274-4504-8806-3b3ee674c8c1
名前 / ファイル | ライセンス | アクション |
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Item type | [ELS]学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-05-24 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | A Novel Cardioprotective Drug, K201 (JTV519), Induces Prolongation of QT and QTc Intervals, but not Torsades de Pointes | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題 | K201 (JTV-519) | |||||
キーワード | ||||||
言語 | en | |||||
主題 | QT interval | |||||
キーワード | ||||||
言語 | en | |||||
主題 | QTc interval | |||||
キーワード | ||||||
言語 | en | |||||
主題 | torsades de pointes | |||||
キーワード | ||||||
言語 | en | |||||
主題 | ryanodine receptor | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
雑誌書誌ID | ||||||
収録物識別子 | AA00629581 | |||||
論文名よみ | ||||||
タイトル | A Novel Cardioprotective Drug, K201 (JTV519), Induces Prolongation of QT and QTc Intervals, but not Torsades de Pointes | |||||
著者 |
Matsuda, Toshiya
× Matsuda, Toshiya× Matsuda, Ryuko× Taguchi, Isao× Toyoda, Shigeru× Kikuchi, Migaku |
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著者所属(英) | ||||||
en | ||||||
Department of Cardiology and Pneumology, Dokkyo University School of Medicine | ||||||
著者所属(英) | ||||||
en | ||||||
Department of Clinical Laboratory Medicine, Dokkyo University School of Medicine | ||||||
著者所属(英) | ||||||
en | ||||||
Department of Cardiology and Pneumology, Dokkyo University School of Medicine | ||||||
著者所属(英) | ||||||
en | ||||||
Department of Cardiology and Pneumology, Dokkyo University School of Medicine | ||||||
著者所属(英) | ||||||
en | ||||||
Department of Cardiology and Pneumology, Dokkyo University School of Medicine | ||||||
記事種別(日) | ||||||
内容記述タイプ | Other | |||||
内容記述 | 原著 | |||||
記事種別(英) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Original | |||||
抄録(英) | ||||||
内容記述タイプ | Other | |||||
内容記述 | K201 (JTV-519; 4-[-3{1-(4-benzyl) piperidinyl} propionyl]-7-methoxy-2, 3, 4, 5-tetrahydro-1, 4-ben-zothiazepine), is a multi-channel blocker and a ryanodine receptor stabilizer that exhibits strong cardiopro-tective and antiarrhythmic effects. In this study, we examined how intravenous infusion of K201 without an α-agonist prolongs the QT interval in chloralose-anaesthetized rabbits, and whether the maximum dose of K201 given concomitantly induces torsades de pointes. The QT interval was significantly prolonged in the group receiving 6-hour infusion of K201 at 20 μg/kg/min, but the QTc interval was not prolonged (n=5). With infusion of K201 at 0 (vehicle; n=5), 40 (n=6), 100 (n=6), 200 (n=6) and 400 μg/kg/min (n=5), blood pressure and HR were decreased, and prolongation of PQ, QRS complex, QT and QTc intervals occurred dose-dependently. The QTc interval was significantly prolonged from 211.5±11.9 ms of the baseline to 319.9±31.1 ms at a concentration of 400 μg/kg/min, which is the maximum dose of K201, but tors-ades de pointes was not induced at this dose. These results show that K201, which has a suppressive effect on Ca^<2+> leakage from the sarcoplasmic reticulum and an α_1-adrenoceptor-blocking effect, does not induce torsades de pointes, although it causes prolongation of the QT interval. | |||||
書誌情報 |
Dokkyo journal of medical sciences 巻 33, 号 1, p. 17-24, 発行日 2006-03-25 |
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ISSN | ||||||
収録物識別子 | 03855023 |