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  1. Dokkyo Journal of Medical Sciences
  2. 33(1) 2006

Plasma Endostatin Levels are Elevated in Patients with Gastric Carcinoma

https://dmu.repo.nii.ac.jp/records/420
https://dmu.repo.nii.ac.jp/records/420
f1c0d1b3-d4fd-40f3-967d-106c8c748ee9
名前 / ファイル ライセンス アクション
KJ00004451269.pdf KJ00004451269.pdf (2.4 MB)
Item type [ELS]学術雑誌論文 / Journal Article(1)
公開日 2017-05-24
タイトル
言語 en
タイトル Plasma Endostatin Levels are Elevated in Patients with Gastric Carcinoma
言語
言語 eng
キーワード
言語 en
主題 Angiogenesis
キーワード
言語 en
主題 Endostatin
キーワード
言語 en
主題 Cathepsin L
キーワード
言語 en
主題 Soluble VEGF R1/Flt-1
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
雑誌書誌ID
収録物識別子 AA00629581
論文名よみ
タイトル Plasma Endostatin Levels are Elevated in Patients with Gastric Carcinoma
著者 Ohkawa, Tetsuya

× Ohkawa, Tetsuya

WEKO 1685

en Ohkawa, Tetsuya

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Miyachi, Kazuhito

× Miyachi, Kazuhito

WEKO 1686

en Miyachi, Kazuhito

Search repository
著者所属(英)
en
First Department of Surgery, Dokkyo University School of Medicine
著者所属(英)
en
First Department of Surgery, Dokkyo University School of Medicine
記事種別(日)
内容記述タイプ Other
内容記述 原著
記事種別(英)
内容記述タイプ Other
内容記述 Original
抄録(英)
内容記述タイプ Other
内容記述 Angiogenesis is a key process in tumor growth and metastasis. In 27 patients with advanced gastric carcinoma before operation and 9 healthy controls, plasma levels of endostatin (ES), cathepsin L (Cat-L) and soluble VEGF R1/Flt-1 (sVEGF R1), which are known to suppress angiogenesis, tumor growth and metastasis, were measured by ELISA in order to examine the clinical importance of the agents. In addition, expression of CD34, ES and Cat-L in tissues of the gastric carcinoma was investigated immunohistochemically in order to elucidate the correlation with the above plasma levels. Plasma ES levels in gastric carcinoma patients were significantly higher than those in controls (p=0.001). Plasma Cat-L levels in controls were slightly lower, though not significantly (p=0.065), than those in carcinoma patients. There was no significant difference in sVEGF R1 levels between gastric carcinoma patients and controls. Expression of ES and Cat-L in tumor tissues was positively associated with plasma sVEGF R1 levels. Expression of CD34 in tumor tissues was not found to be associated with any plasma markers. Our results suggested that plasma ES levels are elevated in gastric carcinoma and may be useful markers for gastric carcinoma.
書誌情報 Dokkyo journal of medical sciences

巻 33, 号 1, p. 25-34, 発行日 2006-03-25
ISSN
収録物識別子 03855023
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