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Plasma Endostatin Levels are Elevated in Patients with Gastric Carcinoma
https://dmu.repo.nii.ac.jp/records/420
https://dmu.repo.nii.ac.jp/records/420f1c0d1b3-d4fd-40f3-967d-106c8c748ee9
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KJ00004451269.pdf (2.4 MB)
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| Item type | [ELS]学術雑誌論文 / Journal Article(1) | |||||||||
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| 公開日 | 2017-05-24 | |||||||||
| タイトル | ||||||||||
| タイトル | Plasma Endostatin Levels are Elevated in Patients with Gastric Carcinoma | |||||||||
| 言語 | en | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題 | Angiogenesis | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題 | Endostatin | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題 | Cathepsin L | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題 | Soluble VEGF R1/Flt-1 | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | journal article | |||||||||
| 雑誌書誌ID | ||||||||||
| 収録物識別子 | AA00629581 | |||||||||
| 論文名よみ | ||||||||||
| タイトル | Plasma Endostatin Levels are Elevated in Patients with Gastric Carcinoma | |||||||||
| 著者 |
Ohkawa, Tetsuya
× Ohkawa, Tetsuya
× Miyachi, Kazuhito
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| 著者所属(英) | ||||||||||
| en | ||||||||||
| First Department of Surgery, Dokkyo University School of Medicine | ||||||||||
| 著者所属(英) | ||||||||||
| en | ||||||||||
| First Department of Surgery, Dokkyo University School of Medicine | ||||||||||
| 記事種別(日) | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | 原著 | |||||||||
| 記事種別(英) | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | Original | |||||||||
| 抄録(英) | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | Angiogenesis is a key process in tumor growth and metastasis. In 27 patients with advanced gastric carcinoma before operation and 9 healthy controls, plasma levels of endostatin (ES), cathepsin L (Cat-L) and soluble VEGF R1/Flt-1 (sVEGF R1), which are known to suppress angiogenesis, tumor growth and metastasis, were measured by ELISA in order to examine the clinical importance of the agents. In addition, expression of CD34, ES and Cat-L in tissues of the gastric carcinoma was investigated immunohistochemically in order to elucidate the correlation with the above plasma levels. Plasma ES levels in gastric carcinoma patients were significantly higher than those in controls (p=0.001). Plasma Cat-L levels in controls were slightly lower, though not significantly (p=0.065), than those in carcinoma patients. There was no significant difference in sVEGF R1 levels between gastric carcinoma patients and controls. Expression of ES and Cat-L in tumor tissues was positively associated with plasma sVEGF R1 levels. Expression of CD34 in tumor tissues was not found to be associated with any plasma markers. Our results suggested that plasma ES levels are elevated in gastric carcinoma and may be useful markers for gastric carcinoma. | |||||||||
| 書誌情報 |
Dokkyo journal of medical sciences 巻 33, 号 1, p. 25-34, 発行日 2006-03-25 |
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| ISSN | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 03855023 | |||||||||
