| Item type |
[ELS]学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-05-24 |
| タイトル |
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タイトル |
Effects of Norepinephrine on Left Ventricular Hemodynamics and Myocardial Blood Flow in Rats with and without Calcium Overload |
|
言語 |
en |
| 言語 |
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|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
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主題 |
norepinephrine |
| キーワード |
|
|
言語 |
en |
|
主題 |
diastolic dysfunction |
| キーワード |
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|
言語 |
en |
|
主題 |
LVEDP |
| キーワード |
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|
言語 |
en |
|
主題 |
calcium |
| キーワード |
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|
言語 |
en |
|
主題 |
myocardial blood flow |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 雑誌書誌ID |
|
|
収録物識別子 |
AA00629581 |
| 論文名よみ |
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タイトル |
Effects of Norepinephrine on Left Ventricular Hemodynamics and Myocardial Blood Flow in Rats with and without Calcium Overload |
| 著者 |
Nakajima, Takahide
Matsuda, Ryuko
Shinozaki, Makoto
Abe, Shichiro
Suzuki, Hidehiko
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| 著者所属(英) |
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en |
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Department of Cardiology and Pneumology, Dokkyo University School of Medicine |
| 著者所属(英) |
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en |
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Department of Clinical Laboratory Medicine, Dokkyo University School of Medicine |
| 著者所属(英) |
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en |
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Department of Cardiology and Pneumology, Dokkyo University School of Medicine |
| 著者所属(英) |
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en |
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Department of Cardiology and Pneumology, Dokkyo University School of Medicine |
| 著者所属(英) |
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|
en |
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Department of Cardiology and Pneumology, Dokkyo University School of Medicine |
| 記事種別(日) |
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内容記述タイプ |
Other |
|
内容記述 |
原著 |
| 記事種別(英) |
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|
内容記述タイプ |
Other |
|
内容記述 |
Original |
| 抄録(英) |
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内容記述タイプ |
Other |
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内容記述 |
Heart failure patients have been shown to have an increased blood norepinephrine concentration, and patients with a high norepinephrine concentration have a poor prognosis. Norepinephrine is a catecholamine with α_1 and β_1 effects, which lead to a vasoconstrictive action and enhancement of myocardial contraction. However, the consequences of norepinephrine-induced changes in myocardial blood flow in heart failure patients remain unknown. In this study, the influence of norepinephrine on hemodynamics and blood flow in the left ventricular myocardium was investigated using rats with and without a calcium load. Norepineph-rine without a calcium load induced a 29.3% reduction of myocardial blood flow (MBF), but had no significant effect on ejection fraction (EF) and left ventricular end-diastolic pressure (LVEDP). With simultaneous calcium administration, norepinephrine induced a 33.2% reduction of MBF and increased LVEDP significantly, but caused no reduction in EF. These results suggest that norepinephrine decreases MBF but has no effects on systolic function, and increases LVEDP and decreases MBF more markedly in combination with calcium. |
| 書誌情報 |
Dokkyo journal of medical sciences
巻 33,
号 1,
p. 35-41,
発行日 2006-03-25
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
03855023 |
KJ00004451270.pdf (688.0 kB)
