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ECP Levels in Nasal Mucus Depend on Eosinophil Collapse
https://dmu.repo.nii.ac.jp/records/496
https://dmu.repo.nii.ac.jp/records/4967036eb09-a7b9-4822-b55f-62f02b2eadf3
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KJ00004701776.pdf (906.6 kB)
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| Item type | [ELS]学術雑誌論文 / Journal Article(1) | |||||||
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| 公開日 | 2017-05-24 | |||||||
| タイトル | ||||||||
| タイトル | ECP Levels in Nasal Mucus Depend on Eosinophil Collapse | |||||||
| 言語 | en | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題 | eosinophil | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題 | degranulation | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題 | ECP | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題 | nasal mucus | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題 | destruction of cell membrane | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題 | destruction index | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | journal article | |||||||
| 雑誌書誌ID | ||||||||
| 収録物識別子 | AA00629581 | |||||||
| 論文名よみ | ||||||||
| タイトル | ECP Levels in Nasal Mucus Depend on Eosinophil Collapse | |||||||
| 著者 |
Kihara, Noriko
× Kihara, Noriko
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| 著者所属(英) | ||||||||
| en | ||||||||
| Department of Otorhinolaryngology, Dokkyo Medical University Koshigaya Hospital | ||||||||
| 記事種別(日) | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | 原著 | |||||||
| 記事種別(英) | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | Original | |||||||
| 抄録(英) | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | Objective : Degranulation of eosinophils is believed to cause epithelial failure. Some researchers have believed that degranulation of eosinophils occurs in the form of piecemeal degranulation (PMD), while others have reported that breakdown of the eosinophil cell membrane causes degranulation. In this study, I examined by which form the eosinophil granule proteins in nasal mucus are mainly released from eosinophils.Methods : Nasal mucus collected by suction were observed by electron microscopically. Total eosinophils, collapsed eosinophils, and vacuolated granules were counted. Destruction of eosinophil cell membrane was classified into 4 ranks by degree of failure of the cell membrane. Granule vacuolation was classified into 3 ranks based on granule properties. A destruction index was defined as the product of the sum of granule vacuolation score and the score for destruction of eosinophil cell membrane. The ECP level in lavage fluid from the nasal cavity was also measured.Results : The ECP level in lavage fluid and score for destruction of eosinophil cell membrane were significantly correlated (R = 0.813, p = 0.0077), while ECP level and destruction index which was derived from both the destruction of cell membrane and granule vacuolation exhibited an even stronger correlation (R = 0.988, p < 0.0001).Conclusion : The eosinophil granule proteins in nasal mucus were released mainly from collapsed eosinophils. | |||||||
| 書誌情報 |
Dokkyo journal of medical sciences 巻 33, 号 3, p. 175-180, 発行日 2006-10-25 |
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| ISSN | ||||||||
| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 03855023 | |||||||
