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  1. Dokkyo Journal of Medical Sciences
  2. 33(3) 2006

ECP Levels in Nasal Mucus Depend on Eosinophil Collapse

https://dmu.repo.nii.ac.jp/records/496
https://dmu.repo.nii.ac.jp/records/496
7036eb09-a7b9-4822-b55f-62f02b2eadf3
名前 / ファイル ライセンス アクション
KJ00004701776.pdf KJ00004701776.pdf (906.6 kB)
Item type [ELS]学術雑誌論文 / Journal Article(1)
公開日 2017-05-24
タイトル
タイトル ECP Levels in Nasal Mucus Depend on Eosinophil Collapse
言語 en
言語
言語 eng
キーワード
言語 en
主題 eosinophil
キーワード
言語 en
主題 degranulation
キーワード
言語 en
主題 ECP
キーワード
言語 en
主題 nasal mucus
キーワード
言語 en
主題 destruction of cell membrane
キーワード
言語 en
主題 destruction index
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
雑誌書誌ID
収録物識別子 AA00629581
論文名よみ
タイトル ECP Levels in Nasal Mucus Depend on Eosinophil Collapse
著者 Kihara, Noriko

× Kihara, Noriko

en Kihara, Noriko

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著者所属(英)
en
Department of Otorhinolaryngology, Dokkyo Medical University Koshigaya Hospital
記事種別(日)
内容記述タイプ Other
内容記述 原著
記事種別(英)
内容記述タイプ Other
内容記述 Original
抄録(英)
内容記述タイプ Other
内容記述 Objective : Degranulation of eosinophils is believed to cause epithelial failure. Some researchers have believed that degranulation of eosinophils occurs in the form of piecemeal degranulation (PMD), while others have reported that breakdown of the eosinophil cell membrane causes degranulation. In this study, I examined by which form the eosinophil granule proteins in nasal mucus are mainly released from eosinophils.Methods : Nasal mucus collected by suction were observed by electron microscopically. Total eosinophils, collapsed eosinophils, and vacuolated granules were counted. Destruction of eosinophil cell membrane was classified into 4 ranks by degree of failure of the cell membrane. Granule vacuolation was classified into 3 ranks based on granule properties. A destruction index was defined as the product of the sum of granule vacuolation score and the score for destruction of eosinophil cell membrane. The ECP level in lavage fluid from the nasal cavity was also measured.Results : The ECP level in lavage fluid and score for destruction of eosinophil cell membrane were significantly correlated (R = 0.813, p = 0.0077), while ECP level and destruction index which was derived from both the destruction of cell membrane and granule vacuolation exhibited an even stronger correlation (R = 0.988, p < 0.0001).Conclusion : The eosinophil granule proteins in nasal mucus were released mainly from collapsed eosinophils.
書誌情報 Dokkyo journal of medical sciences

巻 33, 号 3, p. 175-180, 発行日 2006-10-25
ISSN
収録物識別子タイプ ISSN
収録物識別子 03855023
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