| Item type |
学術雑誌論文 / Journal Article(1) |
| タイトル |
|
|
タイトル |
Thyroid Dysfunction Following Conventional Anthracycline- and Taxane-based Chemotherapy for Breast Cancer |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
chemotherapy |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
hypothyroidism |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
breast cancer |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Kiyomatsu, Hiroko
Ogawa, Toshihisa
Tsuji, Ei-ichi
Hayashibara, Noriaki
Yamaguchi, Nanaka
Nishio, Miki
Hoshi, Yukari
Fujiwara, Hanako
Yoshikata, Marie
Niwa, Takayoshi
|
| 著者所属 |
|
|
|
Department of Breast Surgery, Dokkyo Medical University, Saitama Medical Center |
| 著者所属 |
|
|
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Department of Breast Surgery, Dokkyo Medical University, Saitama Medical Center, Department of Breast and Endocrine Surgery, The University of Tokyo |
| 著者所属 |
|
|
|
Department of Breast Surgery, Dokkyo Medical University, Saitama Medical Center |
| 著者所属 |
|
|
|
Department of Breast Surgery, Dokkyo Medical University, Saitama Medical Center |
| 著者所属 |
|
|
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Department of Breast Surgery, Dokkyo Medical University, Saitama Medical Center |
| 著者所属 |
|
|
|
Department of Breast Surgery, Dokkyo Medical University, Saitama Medical Center |
| 著者所属 |
|
|
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Department of Breast Surgery, Dokkyo Medical University, Saitama Medical Center |
| 著者所属 |
|
|
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Department of Breast Surgery, Dokkyo Medical University, Saitama Medical Center |
| 著者所属 |
|
|
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Department of Breast Surgery, Dokkyo Medical University, Saitama Medical Center |
| 著者所属 |
|
|
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Department of Breast and Endocrine Surgery, The University of Tokyo |
| 書誌情報 |
Dokkyo Medical Journal
巻 1,
号 3,
p. 189-196,
発行日 2022-09
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Although thyroid disorders induced by immune checkpoint inhibitors (ICIs) and tyrosine kinase inhibitors (TKIs) have attracted much attention, little research has been done on thyroid dysfunction in conventional cancer treatment containing anthracyclines and taxanes. We retrospectively studied thyroid function in 61 patients who underwent conventional chemotherapy for breast cancer. Of the 61 patients, 17 (28%) developed thyroid dysfunction, including sub-clinical and overt hypothyroidism following chemotherapy, and 9 (15%) developed overt clinical hypothyroidism. Eight of the nine patients needed thyroid hormone replacement therapy with levothyroxine (L-T4). Taxane-based regimens tended to reduce free T4 levels and increase TSH levels more markedly compared to non-taxane-based regimens. Since the present study showed, for the first time, that conventional chemotherapy, as well as ICIs and TKIs, may induce hypothyroidism, it may be appropriate to evaluate thyroid function during chemotherapy. When patients show the clinical features of hypothyroidism, thyroid hormone replacement therapy merits consideration. |
| 記事種別 |
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Original |
| 出版者 |
|
|
出版者 |
Dokkyo Medical Society |
| ISSN |
|
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
2436-522X |
| DOI |
|
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.51040/dkmj.1.2_85 |
DKMJ-1-3-Kiyomatsu-Fulltext (145.3 kB)
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