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  1. Dokkyo Journal of Medical Sciences
  2. 34(1) 2007

Lissencephaly Type I Associated with Lennox-Gastaut Syndrome in a 20-Year-old man : a Case Report

https://dmu.repo.nii.ac.jp/records/530
https://dmu.repo.nii.ac.jp/records/530
5088fcc0-0e5b-4009-ab1d-00d8e90040bc
名前 / ファイル ライセンス アクション
KJ00005058606.pdf KJ00005058606.pdf (592.0 kB)
Item type [ELS]学術雑誌論文 / Journal Article(1)
公開日 2017-05-24
タイトル
タイトル Lissencephaly Type I Associated with Lennox-Gastaut Syndrome in a 20-Year-old man : a Case Report
言語 en
言語
言語 eng
キーワード
言語 en
主題 Lissencephaly
キーワード
言語 en
主題 West syndrome
キーワード
言語 en
主題 Lennox-Gastaut syndrome
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
雑誌書誌ID
収録物識別子 AA00629581
論文名よみ
タイトル Lissencephaly Type I Associated with Lennox-Gastaut Syndrome in a 20-Year-old man : a Case Report
著者 Imataka, George

× Imataka, George

en Imataka, George

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Mitsui, Masahko

× Mitsui, Masahko

en Mitsui, Masahko

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Konno, Wataru

× Konno, Wataru

en Konno, Wataru

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Hirabayashi, Hideaki

× Hirabayashi, Hideaki

en Hirabayashi, Hideaki

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Hirao, Jun-ichi

× Hirao, Jun-ichi

en Hirao, Jun-ichi

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Yamanouchi, Hideo

× Yamanouchi, Hideo

en Yamanouchi, Hideo

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Arisaka, Osamu

× Arisaka, Osamu

en Arisaka, Osamu

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著者所属(英)
en
Department of Pediatrics, Dokkyo Medical University Tochigi
著者所属(英)
en
Department of Pediatrics, Dokkyo Medical University Tochigi
著者所属(英)
en
Department of Otorhinolaryngology and Bronchoesophagology, Dokkyo Medical University
著者所属(英)
en
Department of Otorhinolaryngology and Bronchoesophagology, Dokkyo Medical University
著者所属(英)
en
Department of Pediatrics, Dokkyo Medical University Tochigi
著者所属(英)
en
Department of Pediatrics, Dokkyo Medical University Tochigi
著者所属(英)
en
Department of Pediatrics, Dokkyo Medical University Tochigi
記事種別(日)
内容記述タイプ Other
内容記述 症例報告
記事種別(英)
内容記述タイプ Other
内容記述 Case Report
抄録(英)
内容記述タイプ Other
内容記述 Lissencephaly is associated with various types of intractable epilepsy. However, complication by Lennox-Gastaut syndrome is rare. We report an adult patient with Lissencephaly type I complicated by Lennox-Gastaut syndrome, along with a review of the literature. Although mild asphyxia was noted in the history of birth, there were no recognized multiple anomalies. His developmental milestones were severely delayed. Partial seizures frequently occurred at the age of 2 months. Brain CT revealed a smooth surface of the brain cortex, and so he was diagnosed with type I lissencephaly. He was treated with several kinds of oral administrations of anti-convulsants, such as phenobarbital, valproric acid, and clonazepam, but progressed into infantile spasms with West syndrome. At the age of 20, he was repeatedly hospitalized due to respiratory infection, and aspiration pneumonia with diffuse aspiration bronchitis. Deformity of the thorax and ventilation disorder associated with severe scoliosis and respiratory muscle atrophy were also noted. His epilepsy was intractable, and tonic and axial seizures repeatedly occurred for a prolonged period. On electroencephalography, a high-amplitude 1.5-Hz spike-and-slow wave complex was dominant in the frontal region, and a rapid rhythm also appeared, based on which Lennox-Gastaut syndrome was diagnosed. Epileptic surgery and tracheotomy were recommended to his parents, but they did not consent. The patient died of rapid aggravation of respiratory infection and the frequent occurrence of epileptic seizures, in addition to chronic respiratory disorder, at 20 years of age.
書誌情報 Dokkyo journal of medical sciences

巻 34, 号 1, p. 53-56, 発行日 2007-03-01
ISSN
収録物識別子タイプ ISSN
収録物識別子 03855023
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