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  1. Dokkyo Medical Journal
  2. 1(4) 2022

Three Cases of Methotrexate-induced Oral Erosion and Ulcers without Conjunctivitis Mimicking Stevens-Johnson Syndrome

https://dmu.repo.nii.ac.jp/records/5365
https://dmu.repo.nii.ac.jp/records/5365
c2169f30-7648-4e67-8dec-b14f22c09bad
名前 / ファイル ライセンス アクション
DKMJ-1-4-11.pdf DKMJ-1-4-Katagiri-Fulltext (439.2 kB)
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Item type 学術雑誌論文 / Journal Article(1)
タイトル
タイトル Three Cases of Methotrexate-induced Oral Erosion and Ulcers without Conjunctivitis Mimicking Stevens-Johnson Syndrome
言語
言語 eng
キーワード
主題Scheme Other
主題 oral mucosal erosions
キーワード
主題Scheme Other
主題 methotrexate
キーワード
主題Scheme Other
主題 myelosuppression
キーワード
主題Scheme Other
主題 Stevens-Johnson syndrome
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
著者 Katagiri, Kazumoto

× Katagiri, Kazumoto

en Katagiri, Kazumoto

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Shinohara, Kana

× Shinohara, Kana

en Shinohara, Kana

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Ichimasu, Nao

× Ichimasu, Nao

en Ichimasu, Nao

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Yamazaki, Marina

× Yamazaki, Marina

en Yamazaki, Marina

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Kawai, Rana

× Kawai, Rana

en Kawai, Rana

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Shimura, Chieko

× Shimura, Chieko

en Shimura, Chieko

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Suyama, Takayuki

× Suyama, Takayuki

en Suyama, Takayuki

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著者所属
Department of Dermatology, Dokkyo Medical University Saitama Medical Center
著者所属
Department of Dermatology, Dokkyo Medical University Saitama Medical Center
著者所属
Department of Dermatology, Dokkyo Medical University Saitama Medical Center
著者所属
Department of Dermatology, Dokkyo Medical University Saitama Medical Center
著者所属
Department of Dermatology, Dokkyo Medical University Saitama Medical Center
著者所属
Department of Dermatology, Dokkyo Medical University Saitama Medical Center
著者所属
Department of Dermatology, Dokkyo Medical University Saitama Medical Center
書誌情報 Dokkyo Medical Journal

巻 1, 号 4, p. 351-355, 発行日 2022-12
抄録
内容記述タイプ Abstract
内容記述 We report three cases of methotrexate (MTX) -induced oral erosions and ulcers mimicking Stevens-Johnson syndrome (SJS) in older women with rheumatoid arthritis, although they did not had conjunctivitis. Furthermore, age, dehydration, and renal dysfunction could trigger adverse reactions of MTX, but one patient underwent dialysis, which is a contraindication for MTX. It is sometimes very difficult to differentiate the toxicity of MTX from SJS. Learning from the three cases, we propose that oral mucosal erosions without conjunctive mucosal inflammation, leukopenia, and thrombocytopenia differentiate MTX toxicity from SJS. Furthermore, our patients nearly recovered from myelosuppression within seven days and recovered from mucosal erosions characteristic of MTX toxicity within 14 days. These clinical courses could also be characteristic for MTX toxicity rather than SJS, although quick recovery does not happen in all cases. Therefore, physicians who prescribe MTX must accurately know MTX-induced adverse reactions to recognize them early. Furthermore, as seen in our patients, oral mucosal erosions occur often. Therefore, dermatologists or others who examine these symptoms should consider that mucosal erosions mimicking SJS could be an adverse reaction of MTX, regardless of whether or not SJS/toxic epidermal necrolysis is suspected.
記事種別
Case Report
出版者
出版者 Dokkyo Medical Society
ISSN
収録物識別子タイプ ISSN
収録物識別子 2436-522X
DOI
識別子タイプ DOI
関連識別子 10.51040/dkmj.2022-021
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