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  1. Dokkyo Journal of Medical Sciences
  2. 34(2) 2007

The Relation Between Adiponectin and four Hypercoagulable, Inflammatory Biomarkers During Normal Pregnancy

https://dmu.repo.nii.ac.jp/records/551
https://dmu.repo.nii.ac.jp/records/551
2868aea5-c47f-47e1-befc-060d04632b70
名前 / ファイル ライセンス アクション
KJ00005058627.pdf KJ00005058627.pdf (711.2 kB)
Item type [ELS]学術雑誌論文 / Journal Article(1)
公開日 2017-05-24
タイトル
言語 en
タイトル The Relation Between Adiponectin and four Hypercoagulable, Inflammatory Biomarkers During Normal Pregnancy
言語
言語 eng
キーワード
言語 en
主題 Adiponectin
キーワード
言語 en
主題 Hypercoagulable state
キーワード
言語 en
主題 Inflammatory state
キーワード
言語 en
主題 Endothelial damage
キーワード
言語 en
主題 Pregnancy
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
雑誌書誌ID
収録物識別子 AA00629581
論文名よみ
タイトル The Relation Between Adiponectin and four Hypercoagulable, Inflammatory Biomarkers During Normal Pregnancy
著者 Tomobe, Katsumi

× Tomobe, Katsumi

WEKO 2196

en Tomobe, Katsumi

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著者所属(英)
en
Department of Obstetrics and Gynecology, Dokkyo Medical University Koshigaya Hospital
記事種別(日)
内容記述タイプ Other
内容記述 原著
記事種別(英)
内容記述タイプ Other
内容記述 Original
抄録(英)
内容記述タイプ Other
内容記述 Eendothelial dysfunction may not occur, even though the hemostatic balance is displaced toward hypercoagulability during pregnancy with enhanced inflammation. Also adiponectin, an adipose tissue-specific plasma protein, was recently revealed to have anti-inflammatory effects on the cellular components of the vascular wall. However, it is still unclear whether or not plasma adiponectin concentrations change during normal pregnancy. Despite a lot of research on the physiological adaptation to pregnancy, relatively little is known about the biological adaptation in the hemostatic, inflammatory changes and endothelial damage. To evaluate the relationship between various biomarkers for endothelial damage and the hypercoagulable, inflammatory state during pregnancy, five biomarkers, namely plasma adiponectin, soluble thrombomodulin (sTM), interleukin (IL)-6, tumor necrosis factor (TNF)-alpha, and thrombin-antithrombin complex (TAT) were measured in 15 nonpregnant healthy women, 60 pregnant women (namely 10th, 20th, 30th, and 38th week of gestation) and 15 postpartum women. The present study revealed that during pregnancy the plasma adiponectin concentrations were increased, while the concentrations of sTM and TNF-alpha did not change and those of TAT and IL-6 were elevated. Elevating the adiponectin concentrations, diminishing endothelial damage and leading to an antithrombotic and anti-inflammatory environment may be beneficial during pregnancy.
書誌情報 Dokkyo journal of medical sciences

巻 34, 号 2, p. 69-77, 発行日 2007-07-01
ISSN
収録物識別子 03855023
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