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  1. Dokkyo Journal of Medical Sciences
  2. 34(3) 2007

Clinical Relevance of the Standardized Uptake Value (Suv) in Staging Breast Cancer with FDG-PET/CT

https://dmu.repo.nii.ac.jp/records/611
https://dmu.repo.nii.ac.jp/records/611
0b873040-b276-473b-bbe5-33c5c840d685
名前 / ファイル ライセンス アクション
KJ00005058715.pdf KJ00005058715.pdf (1.2 MB)
Item type [ELS]学術雑誌論文 / Journal Article(1)
公開日 2017-05-24
タイトル
タイトル Clinical Relevance of the Standardized Uptake Value (Suv) in Staging Breast Cancer with FDG-PET/CT
言語 en
言語
言語 eng
キーワード
言語 en
主題 FDG-PET/CT-SUVmax-Breast cancer-Lymph node spread-Metastasis
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
雑誌書誌ID
収録物識別子 AA00629581
論文名よみ
タイトル Clinical Relevance of the Standardized Uptake Value (Suv) in Staging Breast Cancer with FDG-PET/CT
著者 Zytoon, Ashraf Anas

× Zytoon, Ashraf Anas

en Zytoon, Ashraf Anas

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著者所属(英)
en
PET Center, Dokkyo Medical University
記事種別(日)
内容記述タイプ Other
内容記述 原著
記事種別(英)
内容記述タイプ Other
内容記述 Original
抄録(英)
内容記述タイプ Other
内容記述 Purpose : FDG-PET/CT with standardized uptake value (SUV) estimation was applied to breast cancer patients for the purpose of preoperative evaluation of the extent of the disease. Methods : FDG-PET/CT was performed preoperatively in 71 patients with breast cancer, and the maximum standardized uptake value (SUVmax) of tumors, as well as combination of SUVmax and tumor marker CA 15-3 were investigated for a significant association with lymph node spread and distant metastasis. Results : Tumor SUVmax high (>3.1) was found to have a reliable predictive value for lymph node spread (sensitivity 82.9%, specificity 75%, P<0.0001), while SUVmax-High (>3.8)/CA 15-3-Elevated was found to be superior for the prediction of metastasis (sensitivity ; 75%, specificity ; 92.7%, P=0.0001). Moreover, linear regression analysis identified the best correlation was between SUVmax-High (>3.1) with lymph node spread {correlation coefficient (r^2)=0.580, P=0.0001}, and SUVmax-High (>3.8)/CA 15-3-Elevated with distant metastasis {correlation coefficient (r^2)=0.677, P<0.0001}. Conclusions : SUVmax is a reliable predictor of lymph node spread, and if combined with tumor marker assay (CA 15-3) labeled SUVmax-High/CA 15-3-Elevated is sufficient for the early detection of breast cancer metastasis. This outcome suggests that the FDG-PET/CT findings with SUV calculation could have a strong positive impact on breast cancer patients.
書誌情報 Dokkyo journal of medical sciences

巻 34, 号 3, p. 193-204, 発行日 2007-10-01
ISSN
収録物識別子タイプ ISSN
収録物識別子 03855023
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