| Item type |
[ELS]学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-05-24 |
| タイトル |
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タイトル |
Selection of Postoperative Systemic Chemotherapy for Advanced Gastric Cancer Patients with Hepatic Metastasis Using the Histoculture Drug Response Assay |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題 |
histoculture drug response assay |
| キーワード |
|
|
言語 |
en |
|
主題 |
chemotherapy |
| キーワード |
|
|
言語 |
en |
|
主題 |
gastric cancer |
| キーワード |
|
|
言語 |
en |
|
主題 |
metastasis |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 雑誌書誌ID |
|
|
収録物識別子 |
AA00629581 |
| 論文名よみ |
|
|
タイトル |
Selection of Postoperative Systemic Chemotherapy for Advanced Gastric Cancer Patients with Hepatic Metastasis Using the Histoculture Drug Response Assay |
| 著者 |
Katsumata, Daisuke
Fukui, Hirokazu
Sasaki, Kinro
Miyachi, Kazuhito
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| 著者所属(英) |
|
|
|
en |
|
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First Department of Surgery, Dokkyo Medical University School of Medicine:Department of Surgical and Molecular Pathology, Dokkyo Medical University School of Medicine |
| 著者所属(英) |
|
|
|
en |
|
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First Department of Surgery, Dokkyo Medical University School of Medicine:Department of Surgical and Molecular Pathology, Dokkyo Medical University School of Medicine |
| 著者所属(英) |
|
|
|
en |
|
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First Department of Surgery, Dokkyo Medical University School of Medicine:Department of Surgical and Molecular Pathology, Dokkyo Medical University School of Medicine |
| 著者所属(英) |
|
|
|
en |
|
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First Department of Surgery, Dokkyo Medical University School of Medicine:Department of Surgical and Molecular Pathology, Dokkyo Medical University School of Medicine |
| 記事種別(日) |
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内容記述タイプ |
Other |
|
内容記述 |
原著 |
| 記事種別(英) |
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|
内容記述タイプ |
Other |
|
内容記述 |
Original |
| 抄録(英) |
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|
内容記述タイプ |
Other |
|
内容記述 |
The usefulness of histoculture drug response assay (HDRA) before the start of antitumor chemotherapy was explored to predict the antitumor response of chemotherapy for progressive gastric cancer patients with hepatic metastasis. Cancer tissue was collected from 6 advanced gastric cancer patients with hepatic metastasis, to assess whether the tumor is sensitive to chemotherapeutic agents of 5-fluorouracil (5-FU), mitomycin C (MMC), docetaxel hydrate (TXT), and cisplatin (CDDP) by the HDRA method. The size of hepatic tumor was measured by CT scan 3 and 6 months after the start of the chemotherapy and examined the relationship between the selected chemotherapy and antitumor response. Of 6 patients investigated in the present study, 3 patients received monotherapy with TS-1[○!R], which was found to be effective in 2 patients (66.7%). In the patient who received MMC monotherapy, the HDRA showed the cancer tissue to be less sensitive to any of antitumor agents tested, resultantly indicating no antitumor response. In the remaining 2 patients with combination therapy with TS-1[○!R] and MMC, the selected chemotherapeutic agents showed anti-tumor effect. The HDRA is useful to predict the antitumor response of postoperative adjunctive chemotherapy for advanced gastric cancer patients with hepatic metastasis, and plays an important role in selection of antitumor agents. |
| 書誌情報 |
Dokkyo journal of medical sciences
巻 35,
号 1,
p. 13-17,
発行日 2008-03-01
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| ISSN |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
03855023 |
KJ00005058746.pdf (572.3 kB)
