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  1. Dokkyo Journal of Medical Sciences
  2. 35(1) 2008

Selection of Postoperative Systemic Chemotherapy for Advanced Gastric Cancer Patients with Hepatic Metastasis Using the Histoculture Drug Response Assay

https://dmu.repo.nii.ac.jp/records/642
https://dmu.repo.nii.ac.jp/records/642
edfe3f3a-0dd4-4524-bf0a-8a7a7fb88b59
名前 / ファイル ライセンス アクション
KJ00005058746.pdf KJ00005058746.pdf (572.3 kB)
Item type [ELS]学術雑誌論文 / Journal Article(1)
公開日 2017-05-24
タイトル
言語 en
タイトル Selection of Postoperative Systemic Chemotherapy for Advanced Gastric Cancer Patients with Hepatic Metastasis Using the Histoculture Drug Response Assay
言語
言語 eng
キーワード
言語 en
主題 histoculture drug response assay
キーワード
言語 en
主題 chemotherapy
キーワード
言語 en
主題 gastric cancer
キーワード
言語 en
主題 metastasis
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
雑誌書誌ID
収録物識別子 AA00629581
論文名よみ
タイトル Selection of Postoperative Systemic Chemotherapy for Advanced Gastric Cancer Patients with Hepatic Metastasis Using the Histoculture Drug Response Assay
著者 Katsumata, Daisuke

× Katsumata, Daisuke

WEKO 2618

en Katsumata, Daisuke

Search repository
Fukui, Hirokazu

× Fukui, Hirokazu

WEKO 2619

en Fukui, Hirokazu

Search repository
Sasaki, Kinro

× Sasaki, Kinro

WEKO 2620

en Sasaki, Kinro

Search repository
Miyachi, Kazuhito

× Miyachi, Kazuhito

WEKO 2621

en Miyachi, Kazuhito

Search repository
著者所属(英)
en
First Department of Surgery, Dokkyo Medical University School of Medicine:Department of Surgical and Molecular Pathology, Dokkyo Medical University School of Medicine
著者所属(英)
en
First Department of Surgery, Dokkyo Medical University School of Medicine:Department of Surgical and Molecular Pathology, Dokkyo Medical University School of Medicine
著者所属(英)
en
First Department of Surgery, Dokkyo Medical University School of Medicine:Department of Surgical and Molecular Pathology, Dokkyo Medical University School of Medicine
著者所属(英)
en
First Department of Surgery, Dokkyo Medical University School of Medicine:Department of Surgical and Molecular Pathology, Dokkyo Medical University School of Medicine
記事種別(日)
内容記述タイプ Other
内容記述 原著
記事種別(英)
内容記述タイプ Other
内容記述 Original
抄録(英)
内容記述タイプ Other
内容記述 The usefulness of histoculture drug response assay (HDRA) before the start of antitumor chemotherapy was explored to predict the antitumor response of chemotherapy for progressive gastric cancer patients with hepatic metastasis. Cancer tissue was collected from 6 advanced gastric cancer patients with hepatic metastasis, to assess whether the tumor is sensitive to chemotherapeutic agents of 5-fluorouracil (5-FU), mitomycin C (MMC), docetaxel hydrate (TXT), and cisplatin (CDDP) by the HDRA method. The size of hepatic tumor was measured by CT scan 3 and 6 months after the start of the chemotherapy and examined the relationship between the selected chemotherapy and antitumor response. Of 6 patients investigated in the present study, 3 patients received monotherapy with TS-1[○!R], which was found to be effective in 2 patients (66.7%). In the patient who received MMC monotherapy, the HDRA showed the cancer tissue to be less sensitive to any of antitumor agents tested, resultantly indicating no antitumor response. In the remaining 2 patients with combination therapy with TS-1[○!R] and MMC, the selected chemotherapeutic agents showed anti-tumor effect. The HDRA is useful to predict the antitumor response of postoperative adjunctive chemotherapy for advanced gastric cancer patients with hepatic metastasis, and plays an important role in selection of antitumor agents.
書誌情報 Dokkyo journal of medical sciences

巻 35, 号 1, p. 13-17, 発行日 2008-03-01
ISSN
収録物識別子 03855023
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