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  1. Dokkyo Journal of Medical Sciences
  2. 36(1) 2009

Efonidipine, a Calcium Channel Blocker, Alleviates Renal Injury Induced by Nitric Oxide Synthase Inhibition in Spontaneously Hypertensive Rats

https://dmu.repo.nii.ac.jp/records/749
https://dmu.repo.nii.ac.jp/records/749
3880401f-3dea-4a7d-8c8b-77ee3636a8fe
名前 / ファイル ライセンス アクション
KJ00006349639.pdf KJ00006349639.pdf (265.4 kB)
Item type [ELS]学術雑誌論文 / Journal Article(1)
公開日 2017-05-24
タイトル
タイトル Efonidipine, a Calcium Channel Blocker, Alleviates Renal Injury Induced by Nitric Oxide Synthase Inhibition in Spontaneously Hypertensive Rats
言語 en
言語
言語 eng
キーワード
言語 en
主題 hypertension
キーワード
言語 en
主題 nephrosclerosis
キーワード
言語 en
主題 calcium channel blockers
キーワード
言語 en
主題 transforming growth factor-beta
キーワード
言語 en
主題 peroxisome proliferator-activated receptors
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
雑誌書誌ID
収録物識別子 AA00629581
論文名よみ
タイトル Efonidipine, a Calcium Channel Blocker, Alleviates Renal Injury Induced by Nitric Oxide Synthase Inhibition in Spontaneously Hypertensive Rats
著者 Kameda, Tomoko

× Kameda, Tomoko

en Kameda, Tomoko

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Ono, Hidehiko

× Ono, Hidehiko

en Ono, Hidehiko

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Ono, Yuko

× Ono, Yuko

en Ono, Yuko

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Ishimitsu, Toshihiko

× Ishimitsu, Toshihiko

en Ishimitsu, Toshihiko

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著者所属(英)
en
Department of Hypertension and Cardiorenal Medicine, Dokkyo Medical University School of MedicineMibu
著者所属(英)
en
Department of Hypertension and Cardiorenal Medicine, Dokkyo Medical University School of MedicineMibu
著者所属(英)
en
Department of Pathology, Dokkyo Medical University Koshigaya Hospital, Koshigaya, Saitama
著者所属(英)
en
Department of Hypertension and Cardiorenal Medicine, Dokkyo Medical University School of MedicineMibu
記事種別(日)
内容記述タイプ Other
内容記述 原著
記事種別(英)
内容記述タイプ Other
内容記述 Original
抄録(英)
内容記述タイプ Other
内容記述 This study was designed to evaluate the protective effects of efonidipine, an L- and T-type calcium channelblocker, against hypertensive renal injuries in spontaneously hypertensive rats( SHR) chronically treatedwith N-nitro-L-arginine methyl ester( L-NAME), a nitric oxide synthase inhibiter. Four groups of seventeen-week-old male SHR were treated for as follows:the control group, the L-NAME group given80 mg/L L-NAME in drinking water, and the groups given 5( low-dose) or 20( high-dose) mg/kg/day efonidipineby gavage as well as 80 mg/L L-NAME in drinking. After three weeks, the rats were sacrificedand the degrees of renal injuries were compared. The L-NAME group developed renal dysfunction and renaltissue lesions such as glomerulosclerosis, arterial wall thickening and perivascular fibrosis and cell infiltrationwith the aggravation of hypertension. The high-dose efonidipine improved the renal function and alleviatedthe renal tissue lesions in SHR given L-NAME as well as lowering blood pressure. On the otherhand, the low-dose efonidipine also exhibited such renoprotective effects without causing significant changesof blood pressure in L-NAME-treated SHR. Renal cortical mRNA expressions of transforming growthfactor-b 1 (TGF-b 1) and peroxisome proliferator-activated receptor-g (PPAR-g) were increased and decreased,respectively, in SHR given L-NAME. Such changes in the mRNA expressions were mitigated byeither the low-dose or the high-dose efonidipine treatment. It is suggested that efonidipine is effective in inhibitingthe progression of hypertensive renal injuries and the renoprotective effects are mediated by themechanism independent of blood pressure reduction as well as by the antihypertensive action.
書誌情報 Dokkyo journal of medical sciences

巻 36, 号 1, p. 9-16, 発行日 2009-03-25
ISSN
収録物識別子タイプ ISSN
収録物識別子 03855023
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