| Item type |
[ELS]学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-05-24 |
| タイトル |
|
|
タイトル |
Efonidipine, a Calcium Channel Blocker, Alleviates Renal Injury Induced by Nitric Oxide Synthase Inhibition in Spontaneously Hypertensive Rats |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題 |
hypertension |
| キーワード |
|
|
言語 |
en |
|
主題 |
nephrosclerosis |
| キーワード |
|
|
言語 |
en |
|
主題 |
calcium channel blockers |
| キーワード |
|
|
言語 |
en |
|
主題 |
transforming growth factor-beta |
| キーワード |
|
|
言語 |
en |
|
主題 |
peroxisome proliferator-activated receptors |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 雑誌書誌ID |
|
|
収録物識別子 |
AA00629581 |
| 論文名よみ |
|
|
タイトル |
Efonidipine, a Calcium Channel Blocker, Alleviates Renal Injury Induced by Nitric Oxide Synthase Inhibition in Spontaneously Hypertensive Rats |
| 著者 |
Kameda, Tomoko
Ono, Hidehiko
Ono, Yuko
Ishimitsu, Toshihiko
|
| 著者所属(英) |
|
|
|
en |
|
|
Department of Hypertension and Cardiorenal Medicine, Dokkyo Medical University School of MedicineMibu |
| 著者所属(英) |
|
|
|
en |
|
|
Department of Hypertension and Cardiorenal Medicine, Dokkyo Medical University School of MedicineMibu |
| 著者所属(英) |
|
|
|
en |
|
|
Department of Pathology, Dokkyo Medical University Koshigaya Hospital, Koshigaya, Saitama |
| 著者所属(英) |
|
|
|
en |
|
|
Department of Hypertension and Cardiorenal Medicine, Dokkyo Medical University School of MedicineMibu |
| 記事種別(日) |
|
|
内容記述タイプ |
Other |
|
内容記述 |
原著 |
| 記事種別(英) |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Original |
| 抄録(英) |
|
|
内容記述タイプ |
Other |
|
内容記述 |
This study was designed to evaluate the protective effects of efonidipine, an L- and T-type calcium channelblocker, against hypertensive renal injuries in spontaneously hypertensive rats( SHR) chronically treatedwith N-nitro-L-arginine methyl ester( L-NAME), a nitric oxide synthase inhibiter. Four groups of seventeen-week-old male SHR were treated for as follows:the control group, the L-NAME group given80 mg/L L-NAME in drinking water, and the groups given 5( low-dose) or 20( high-dose) mg/kg/day efonidipineby gavage as well as 80 mg/L L-NAME in drinking. After three weeks, the rats were sacrificedand the degrees of renal injuries were compared. The L-NAME group developed renal dysfunction and renaltissue lesions such as glomerulosclerosis, arterial wall thickening and perivascular fibrosis and cell infiltrationwith the aggravation of hypertension. The high-dose efonidipine improved the renal function and alleviatedthe renal tissue lesions in SHR given L-NAME as well as lowering blood pressure. On the otherhand, the low-dose efonidipine also exhibited such renoprotective effects without causing significant changesof blood pressure in L-NAME-treated SHR. Renal cortical mRNA expressions of transforming growthfactor-b 1 (TGF-b 1) and peroxisome proliferator-activated receptor-g (PPAR-g) were increased and decreased,respectively, in SHR given L-NAME. Such changes in the mRNA expressions were mitigated byeither the low-dose or the high-dose efonidipine treatment. It is suggested that efonidipine is effective in inhibitingthe progression of hypertensive renal injuries and the renoprotective effects are mediated by themechanism independent of blood pressure reduction as well as by the antihypertensive action. |
| 書誌情報 |
Dokkyo journal of medical sciences
巻 36,
号 1,
p. 9-16,
発行日 2009-03-25
|
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
03855023 |
KJ00006349639.pdf (265.4 kB)
