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  1. Dokkyo Journal of Medical Sciences
  2. 36(1) 2009

Pathological Approach for Surveillance of Ulcerative Colitis-associated cancer:Usefulness of Immunohistochemistry for p53

https://dmu.repo.nii.ac.jp/records/751
https://dmu.repo.nii.ac.jp/records/751
cae7749f-1740-4924-b46e-9d04c007f15d
名前 / ファイル ライセンス アクション
KJ00006350460.pdf KJ00006350460.pdf (151.7 kB)
Item type [ELS]学術雑誌論文 / Journal Article(1)
公開日 2017-05-24
タイトル
タイトル Pathological Approach for Surveillance of Ulcerative Colitis-associated cancer:Usefulness of Immunohistochemistry for p53
言語 en
言語
言語 eng
キーワード
言語 en
主題 ulcerative colitis
キーワード
言語 en
主題 cancer
キーワード
言語 en
主題 p53
キーワード
言語 en
主題 immunohistochemistry
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
雑誌書誌ID
収録物識別子 AA00629581
論文名よみ
タイトル Pathological Approach for Surveillance of Ulcerative Colitis-associated cancer:Usefulness of Immunohistochemistry for p53
著者 Yamagishi, Hidetsugu

× Yamagishi, Hidetsugu

en Yamagishi, Hidetsugu

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Fukui, Hirokazu

× Fukui, Hirokazu

en Fukui, Hirokazu

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Fujii, Shigehiko

× Fujii, Shigehiko

en Fujii, Shigehiko

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Hiraishi, Hideyuki

× Hiraishi, Hideyuki

en Hiraishi, Hideyuki

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Fujimori, Takahiro

× Fujimori, Takahiro

en Fujimori, Takahiro

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著者所属(英)
en
Department of Surgical and Molecular Pathology,Department of Gastroenterology, Dokkyo Medical University School of Medicine
著者所属(英)
en
Department of Surgical and Molecular Pathology
著者所属(英)
en
Department of Surgical and Molecular Pathology
著者所属(英)
en
Department of Gastroenterology, Dokkyo Medical University School of Medicine
著者所属(英)
en
Department of Surgical and Molecular Pathology
記事種別(日)
内容記述タイプ Other
内容記述 原著
記事種別(英)
内容記述タイプ Other
内容記述 Original
抄録(英)
内容記述タイプ Other
内容記述 The patients with long-standing ulcerative colitis( UC) have a high-risk of neoplastic lesions in the colonicmucosa. The UC-associated neoplastic lesion is difficult to detect by endoscopic examination or diagnosehistologically. In the present study, we aimed to clarify whether immunohistochemistry for p53 is useful todiscriminate the UC-associated neoplasia from inflammed regenerating epithelium. Tissue samples were obtainedfrom colorectomy specimens from 20 patients with long-standing UC (range 6-29 years). The surfaceof microstructure of the tissues was observed by stereomicroscopy, and the sections were examined usingimmunohistochemistry for p53. All of T2-4 carcinomas were detectable by endoscopic examination beforesurgery, whereas considerable number of dysplasias (52.5%), Tis carcinomas (33.3%), and T1 carcinomas(60.0%) were undetectable. Fifty-three of 67 UC-associated neoplastic lesions (79.1%) were of flat-typemacroscopically. The detection rate of flat-type neoplasias( 45.3%) was significantly lower than that of protrudingones (100%). The positivity of p53 overexpression was 0 % in UC-II, 52.5 % in UC-III, and 70.4 %in UC-IV, respectively. UC-II lesions had lower positivity of p53 overexpression than UC-III( P=0.027) or-IV lesions( P=0.003). Immunohistochemical analysis of p53 protein is useful to discriminate the UC-associatedneoplasia from inflammed regenerating epithelium.
書誌情報 Dokkyo journal of medical sciences

巻 36, 号 1, p. 27-32, 発行日 2009-03-25
ISSN
収録物識別子タイプ ISSN
収録物識別子 03855023
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