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Pathological Approach for Surveillance of Ulcerative Colitis-associated cancer:Usefulness of Immunohistochemistry for p53
https://dmu.repo.nii.ac.jp/records/751
https://dmu.repo.nii.ac.jp/records/751cae7749f-1740-4924-b46e-9d04c007f15d
名前 / ファイル | ライセンス | アクション |
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Item type | [ELS]学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-05-24 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Pathological Approach for Surveillance of Ulcerative Colitis-associated cancer:Usefulness of Immunohistochemistry for p53 | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題 | ulcerative colitis | |||||
キーワード | ||||||
言語 | en | |||||
主題 | cancer | |||||
キーワード | ||||||
言語 | en | |||||
主題 | p53 | |||||
キーワード | ||||||
言語 | en | |||||
主題 | immunohistochemistry | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
雑誌書誌ID | ||||||
収録物識別子 | AA00629581 | |||||
論文名よみ | ||||||
タイトル | Pathological Approach for Surveillance of Ulcerative Colitis-associated cancer:Usefulness of Immunohistochemistry for p53 | |||||
著者 |
Yamagishi, Hidetsugu
× Yamagishi, Hidetsugu× Fukui, Hirokazu× Fujii, Shigehiko× Hiraishi, Hideyuki× Fujimori, Takahiro |
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著者所属(英) | ||||||
en | ||||||
Department of Surgical and Molecular Pathology,Department of Gastroenterology, Dokkyo Medical University School of Medicine | ||||||
著者所属(英) | ||||||
en | ||||||
Department of Surgical and Molecular Pathology | ||||||
著者所属(英) | ||||||
en | ||||||
Department of Surgical and Molecular Pathology | ||||||
著者所属(英) | ||||||
en | ||||||
Department of Gastroenterology, Dokkyo Medical University School of Medicine | ||||||
著者所属(英) | ||||||
en | ||||||
Department of Surgical and Molecular Pathology | ||||||
記事種別(日) | ||||||
内容記述タイプ | Other | |||||
内容記述 | 原著 | |||||
記事種別(英) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Original | |||||
抄録(英) | ||||||
内容記述タイプ | Other | |||||
内容記述 | The patients with long-standing ulcerative colitis( UC) have a high-risk of neoplastic lesions in the colonicmucosa. The UC-associated neoplastic lesion is difficult to detect by endoscopic examination or diagnosehistologically. In the present study, we aimed to clarify whether immunohistochemistry for p53 is useful todiscriminate the UC-associated neoplasia from inflammed regenerating epithelium. Tissue samples were obtainedfrom colorectomy specimens from 20 patients with long-standing UC (range 6-29 years). The surfaceof microstructure of the tissues was observed by stereomicroscopy, and the sections were examined usingimmunohistochemistry for p53. All of T2-4 carcinomas were detectable by endoscopic examination beforesurgery, whereas considerable number of dysplasias (52.5%), Tis carcinomas (33.3%), and T1 carcinomas(60.0%) were undetectable. Fifty-three of 67 UC-associated neoplastic lesions (79.1%) were of flat-typemacroscopically. The detection rate of flat-type neoplasias( 45.3%) was significantly lower than that of protrudingones (100%). The positivity of p53 overexpression was 0 % in UC-II, 52.5 % in UC-III, and 70.4 %in UC-IV, respectively. UC-II lesions had lower positivity of p53 overexpression than UC-III( P=0.027) or-IV lesions( P=0.003). Immunohistochemical analysis of p53 protein is useful to discriminate the UC-associatedneoplasia from inflammed regenerating epithelium. | |||||
書誌情報 |
Dokkyo journal of medical sciences 巻 36, 号 1, p. 27-32, 発行日 2009-03-25 |
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ISSN | ||||||
収録物識別子 | 03855023 |