| Item type |
[ELS]学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-05-24 |
| タイトル |
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タイトル |
Pathological Approach for Surveillance of Ulcerative Colitis-associated cancer:Usefulness of Immunohistochemistry for p53 |
|
言語 |
en |
| 言語 |
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|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題 |
ulcerative colitis |
| キーワード |
|
|
言語 |
en |
|
主題 |
cancer |
| キーワード |
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|
言語 |
en |
|
主題 |
p53 |
| キーワード |
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|
言語 |
en |
|
主題 |
immunohistochemistry |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 雑誌書誌ID |
|
|
収録物識別子 |
AA00629581 |
| 論文名よみ |
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|
タイトル |
Pathological Approach for Surveillance of Ulcerative Colitis-associated cancer:Usefulness of Immunohistochemistry for p53 |
| 著者 |
Yamagishi, Hidetsugu
Fukui, Hirokazu
Fujii, Shigehiko
Hiraishi, Hideyuki
Fujimori, Takahiro
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| 著者所属(英) |
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en |
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Department of Surgical and Molecular Pathology,Department of Gastroenterology, Dokkyo Medical University School of Medicine |
| 著者所属(英) |
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en |
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Department of Surgical and Molecular Pathology |
| 著者所属(英) |
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|
en |
|
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Department of Surgical and Molecular Pathology |
| 著者所属(英) |
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en |
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Department of Gastroenterology, Dokkyo Medical University School of Medicine |
| 著者所属(英) |
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en |
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Department of Surgical and Molecular Pathology |
| 記事種別(日) |
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内容記述タイプ |
Other |
|
内容記述 |
原著 |
| 記事種別(英) |
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|
内容記述タイプ |
Other |
|
内容記述 |
Original |
| 抄録(英) |
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|
内容記述タイプ |
Other |
|
内容記述 |
The patients with long-standing ulcerative colitis( UC) have a high-risk of neoplastic lesions in the colonicmucosa. The UC-associated neoplastic lesion is difficult to detect by endoscopic examination or diagnosehistologically. In the present study, we aimed to clarify whether immunohistochemistry for p53 is useful todiscriminate the UC-associated neoplasia from inflammed regenerating epithelium. Tissue samples were obtainedfrom colorectomy specimens from 20 patients with long-standing UC (range 6-29 years). The surfaceof microstructure of the tissues was observed by stereomicroscopy, and the sections were examined usingimmunohistochemistry for p53. All of T2-4 carcinomas were detectable by endoscopic examination beforesurgery, whereas considerable number of dysplasias (52.5%), Tis carcinomas (33.3%), and T1 carcinomas(60.0%) were undetectable. Fifty-three of 67 UC-associated neoplastic lesions (79.1%) were of flat-typemacroscopically. The detection rate of flat-type neoplasias( 45.3%) was significantly lower than that of protrudingones (100%). The positivity of p53 overexpression was 0 % in UC-II, 52.5 % in UC-III, and 70.4 %in UC-IV, respectively. UC-II lesions had lower positivity of p53 overexpression than UC-III( P=0.027) or-IV lesions( P=0.003). Immunohistochemical analysis of p53 protein is useful to discriminate the UC-associatedneoplasia from inflammed regenerating epithelium. |
| 書誌情報 |
Dokkyo journal of medical sciences
巻 36,
号 1,
p. 27-32,
発行日 2009-03-25
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| ISSN |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
03855023 |
KJ00006350460.pdf (151.7 kB)
