{"_buckets": {"deposit": "642751ad-02c4-460e-ab84-3008eb16ed3f"}, "_deposit": {"created_by": 3, "id": "751", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "751"}, "status": "published"}, "_oai": {"id": "oai:dmu.repo.nii.ac.jp:00000751", "sets": ["49"]}, "author_link": ["3132", "3130", "3134", "3131", "3133"], "item_2_biblio_info_12": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2009-03-25", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "32", "bibliographicPageStart": "27", "bibliographicVolumeNumber": "36", "bibliographic_titles": [{"bibliographic_title": "Dokkyo journal of medical sciences"}]}]}, "item_2_description_11": {"attribute_name": "抄録(英)", "attribute_value_mlt": [{"subitem_description": "The patients with long-standing ulcerative colitis( UC) have a high-risk of neoplastic lesions in the colonicmucosa. The UC-associated neoplastic lesion is difficult to detect by endoscopic examination or diagnosehistologically. In the present study, we aimed to clarify whether immunohistochemistry for p53 is useful todiscriminate the UC-associated neoplasia from inflammed regenerating epithelium. Tissue samples were obtainedfrom colorectomy specimens from 20 patients with long-standing UC (range 6-29 years). The surfaceof microstructure of the tissues was observed by stereomicroscopy, and the sections were examined usingimmunohistochemistry for p53. All of T2-4 carcinomas were detectable by endoscopic examination beforesurgery, whereas considerable number of dysplasias (52.5%), Tis carcinomas (33.3%), and T1 carcinomas(60.0%) were undetectable. Fifty-three of 67 UC-associated neoplastic lesions (79.1%) were of flat-typemacroscopically. The detection rate of flat-type neoplasias( 45.3%) was significantly lower than that of protrudingones (100%). The positivity of p53 overexpression was 0 % in UC-II, 52.5 % in UC-III, and 70.4 %in UC-IV, respectively. UC-II lesions had lower positivity of p53 overexpression than UC-III( P=0.027) or-IV lesions( P=0.003). Immunohistochemical analysis of p53 protein is useful to discriminate the UC-associatedneoplasia from inflammed regenerating epithelium.", "subitem_description_type": "Other"}]}, "item_2_description_15": {"attribute_name": "表示順", "attribute_value_mlt": [{"subitem_description": "5", "subitem_description_type": "Other"}]}, "item_2_description_16": {"attribute_name": "アクセション番号", "attribute_value_mlt": [{"subitem_description": "KJ00006350460", "subitem_description_type": "Other"}]}, "item_2_description_8": {"attribute_name": "記事種別(日)", "attribute_value_mlt": [{"subitem_description": "原著", "subitem_description_type": "Other"}]}, "item_2_description_9": {"attribute_name": "記事種別(英)", "attribute_value_mlt": [{"subitem_description": "Original", "subitem_description_type": "Other"}]}, "item_2_source_id_1": {"attribute_name": "雑誌書誌ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00629581", "subitem_source_identifier_type": "NCID"}]}, "item_2_source_id_19": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "03855023", "subitem_source_identifier_type": "ISSN"}]}, "item_2_text_7": {"attribute_name": "著者所属(英)", "attribute_value_mlt": [{"subitem_text_language": "en", "subitem_text_value": "Department of Surgical and Molecular Pathology,Department of Gastroenterology, Dokkyo Medical University School of Medicine"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Surgical and Molecular Pathology"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Surgical and Molecular Pathology"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Gastroenterology, Dokkyo Medical University School of Medicine"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Surgical and Molecular Pathology"}]}, "item_2_title_3": {"attribute_name": "論文名よみ", "attribute_value_mlt": [{"subitem_title": "Pathological Approach for Surveillance of Ulcerative Colitis-associated cancer:Usefulness of Immunohistochemistry for p53"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Yamagishi, Hidetsugu", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "3130", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Fukui, Hirokazu", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "3131", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Fujii, Shigehiko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "3132", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hiraishi, Hideyuki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "3133", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Fujimori, Takahiro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "3134", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-05-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "KJ00006350460.pdf", "filesize": [{"value": "151.7 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 151700.0, "url": {"label": "KJ00006350460.pdf", "url": "https://dmu.repo.nii.ac.jp/record/751/files/KJ00006350460.pdf"}, "version_id": "e8a9ac65-bc9f-4187-b7b2-c4a6316b40ce"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "ulcerative colitis", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "cancer", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "p53", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "immunohistochemistry", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Pathological Approach for Surveillance of Ulcerative Colitis-associated cancer:Usefulness of Immunohistochemistry for p53", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Pathological Approach for Surveillance of Ulcerative Colitis-associated cancer:Usefulness of Immunohistochemistry for p53", "subitem_title_language": "en"}]}, "item_type_id": "2", "owner": "3", "path": ["49"], "permalink_uri": "https://dmu.repo.nii.ac.jp/records/751", "pubdate": {"attribute_name": "公開日", "attribute_value": "2017-05-24"}, "publish_date": "2017-05-24", "publish_status": "0", "recid": "751", "relation": {}, "relation_version_is_last": true, "title": ["Pathological Approach for Surveillance of Ulcerative Colitis-associated cancer:Usefulness of Immunohistochemistry for p53"], "weko_shared_id": 3}