| Item type |
[ELS]学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-05-24 |
| タイトル |
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タイトル |
Immunohistochemical Localization of REG Ia Protein in Salivary Gland Tumors |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題 |
REG Ia protein |
| キーワード |
|
|
言語 |
en |
|
主題 |
proliferation |
| キーワード |
|
|
言語 |
en |
|
主題 |
salivary |
| 資源タイプ |
|
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 雑誌書誌ID |
|
|
収録物識別子 |
AA00629581 |
| 論文名よみ |
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タイトル |
Immunohistochemical Localization of REG Ia Protein in Salivary Gland Tumors |
| 著者 |
Kimura, Tokiko
Fukui, Hirokazu
Sekikawa, Akira
Yamagishi, Hidetsugu
Ichikawa, Kazuhito
Tomita, Shigeki
Fujii, Shigehiko
Johji, Imura
Kawamata, Hitoshi
Imai, Yutaka
Fujimori, Takahiro
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| 著者所属(英) |
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en |
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Department of Surgical and Molecular Pathology, Dokkyo Medical University School of Medicine |
| 著者所属(英) |
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en |
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Department of Surgical and Molecular Pathology |
| 著者所属(英) |
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en |
|
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Department of Surgical and Molecular Pathology |
| 著者所属(英) |
|
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en |
|
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Department of Surgical and Molecular Pathology |
| 著者所属(英) |
|
|
|
en |
|
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Department of Surgical and Molecular Pathology |
| 著者所属(英) |
|
|
|
en |
|
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Department of Surgical and Molecular Pathology |
| 著者所属(英) |
|
|
|
en |
|
|
Department of Surgical and Molecular Pathology |
| 著者所属(英) |
|
|
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en |
|
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Department of Surgical and Molecular Pathology |
| 著者所属(英) |
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en |
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Department of Oral Surgery, Dokkyo Medical University |
| 著者所属(英) |
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en |
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Department of Oral Surgery, Dokkyo Medical University School of Medicine |
| 著者所属(英) |
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en |
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Department of Surgical and Molecular Pathology |
| 記事種別(日) |
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内容記述タイプ |
Other |
|
内容記述 |
原著 |
| 記事種別(英) |
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|
内容記述タイプ |
Other |
|
内容記述 |
Original |
| 抄録(英) |
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|
内容記述タイプ |
Other |
|
内容記述 |
The regenerating gene( Reg) Ia protein has a trophic effect on gastric epithelial cells, and its overexpressionis reported in gastrointestinal cancers. The salivary gland is a component of the digestive system, andtherefore, REG Ia protein may play some role in the pathophysiology of salivary gland tumors. In the presentstudy, we determined the immunohistochemical localization of REG Ia protein in salivary gland tumorsand moreover investigated its relationship to clinicopathological features. Twenty-eight patients with salivarygland tumor were enrolled. The specimens resected by surgery from those patients were examinedusing immunohistochemistry for REG Ia protein and Ki67. Five of the 16 pleomorphic adenomas (31.3%)were positive for REG Ia protein. Regarding salivary gland carcinomas, four of five mucoepidermoid carcinomas(80%), three of five adenoid cystic carcinomas (60%), one of two polymorphous low-grade adenocarcinomas(50%) were also positive for REG Ia protein. However, no relationships were found betweenREG Ia protein expression and clinicopathological features. Regarding the Ki67 expression, strong signalwas observed in the tumor cells of patients with salivary gland adenoma as well as carcinoma. REG Ia proteinis expressed not only in adenocarcinoma but also precancerous adenoma cells proliferating actively,suggesting that REG Ia protein may play a role at least in part in the development of salivary gland tumors. |
| 書誌情報 |
Dokkyo journal of medical sciences
巻 36,
号 1,
p. 33-38,
発行日 2009-03-25
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| ISSN |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
03855023 |
KJ00006352920.pdf (353.3 kB)
