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  1. Dokkyo Journal of Medical Sciences
  2. 36(1) 2009

Immunohistochemical Localization of REG Ia Protein in Salivary Gland Tumors

https://dmu.repo.nii.ac.jp/records/752
https://dmu.repo.nii.ac.jp/records/752
e83e62ac-ff5c-462b-9ba9-6b8044c2de70
名前 / ファイル ライセンス アクション
KJ00006352920.pdf KJ00006352920.pdf (353.3 kB)
Item type [ELS]学術雑誌論文 / Journal Article(1)
公開日 2017-05-24
タイトル
タイトル Immunohistochemical Localization of REG Ia Protein in Salivary Gland Tumors
言語 en
言語
言語 eng
キーワード
言語 en
主題 REG Ia protein
キーワード
言語 en
主題 proliferation
キーワード
言語 en
主題 salivary
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
雑誌書誌ID
収録物識別子 AA00629581
論文名よみ
タイトル Immunohistochemical Localization of REG Ia Protein in Salivary Gland Tumors
著者 Kimura, Tokiko

× Kimura, Tokiko

en Kimura, Tokiko

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Fukui, Hirokazu

× Fukui, Hirokazu

en Fukui, Hirokazu

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Sekikawa, Akira

× Sekikawa, Akira

en Sekikawa, Akira

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Yamagishi, Hidetsugu

× Yamagishi, Hidetsugu

en Yamagishi, Hidetsugu

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Ichikawa, Kazuhito

× Ichikawa, Kazuhito

en Ichikawa, Kazuhito

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Tomita, Shigeki

× Tomita, Shigeki

en Tomita, Shigeki

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Fujii, Shigehiko

× Fujii, Shigehiko

en Fujii, Shigehiko

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Johji, Imura

× Johji, Imura

en Johji, Imura

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Kawamata, Hitoshi

× Kawamata, Hitoshi

en Kawamata, Hitoshi

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Imai, Yutaka

× Imai, Yutaka

en Imai, Yutaka

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Fujimori, Takahiro

× Fujimori, Takahiro

en Fujimori, Takahiro

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著者所属(英)
en
Department of Surgical and Molecular Pathology, Dokkyo Medical University School of Medicine
著者所属(英)
en
Department of Surgical and Molecular Pathology
著者所属(英)
en
Department of Surgical and Molecular Pathology
著者所属(英)
en
Department of Surgical and Molecular Pathology
著者所属(英)
en
Department of Surgical and Molecular Pathology
著者所属(英)
en
Department of Surgical and Molecular Pathology
著者所属(英)
en
Department of Surgical and Molecular Pathology
著者所属(英)
en
Department of Surgical and Molecular Pathology
著者所属(英)
en
Department of Oral Surgery, Dokkyo Medical University
著者所属(英)
en
Department of Oral Surgery, Dokkyo Medical University School of Medicine
著者所属(英)
en
Department of Surgical and Molecular Pathology
記事種別(日)
内容記述タイプ Other
内容記述 原著
記事種別(英)
内容記述タイプ Other
内容記述 Original
抄録(英)
内容記述タイプ Other
内容記述 The regenerating gene( Reg) Ia protein has a trophic effect on gastric epithelial cells, and its overexpressionis reported in gastrointestinal cancers. The salivary gland is a component of the digestive system, andtherefore, REG Ia protein may play some role in the pathophysiology of salivary gland tumors. In the presentstudy, we determined the immunohistochemical localization of REG Ia protein in salivary gland tumorsand moreover investigated its relationship to clinicopathological features. Twenty-eight patients with salivarygland tumor were enrolled. The specimens resected by surgery from those patients were examinedusing immunohistochemistry for REG Ia protein and Ki67. Five of the 16 pleomorphic adenomas (31.3%)were positive for REG Ia protein. Regarding salivary gland carcinomas, four of five mucoepidermoid carcinomas(80%), three of five adenoid cystic carcinomas (60%), one of two polymorphous low-grade adenocarcinomas(50%) were also positive for REG Ia protein. However, no relationships were found betweenREG Ia protein expression and clinicopathological features. Regarding the Ki67 expression, strong signalwas observed in the tumor cells of patients with salivary gland adenoma as well as carcinoma. REG Ia proteinis expressed not only in adenocarcinoma but also precancerous adenoma cells proliferating actively,suggesting that REG Ia protein may play a role at least in part in the development of salivary gland tumors.
書誌情報 Dokkyo journal of medical sciences

巻 36, 号 1, p. 33-38, 発行日 2009-03-25
ISSN
収録物識別子タイプ ISSN
収録物識別子 03855023
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