| Item type |
[ELS]学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-05-24 |
| タイトル |
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|
タイトル |
Localization of Stem Cells in Small Intestinal Epithelium:Strategies for Identifying Small Intestinal Stem Cells |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題 |
stem cell |
| キーワード |
|
|
言語 |
en |
|
主題 |
small intestine |
| キーワード |
|
|
言語 |
en |
|
主題 |
Musashi-1 |
| キーワード |
|
|
言語 |
en |
|
主題 |
Hes1 |
| キーワード |
|
|
言語 |
en |
|
主題 |
crypt base columnar cell |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 雑誌書誌ID |
|
|
収録物識別子 |
AA00629581 |
| 論文名よみ |
|
|
タイトル |
Localization of Stem Cells in Small Intestinal Epithelium:Strategies for Identifying Small Intestinal Stem Cells |
| 著者 |
Suzuki, Katsumasa
Fujimori, Yukari
Fujimori, Takahiro
|
| 著者所属(英) |
|
|
|
en |
|
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Keinan Sogo Hospital : Department of Surgical and Molecular Pathology, Dokkyo Medical University School of Medicine |
| 著者所属(英) |
|
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en |
|
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Department of Surgical and Molecular Pathology, Dokkyo Medical University School of Medicine |
| 著者所属(英) |
|
|
|
en |
|
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Department of Surgical and Molecular Pathology, Dokkyo Medical University School of Medicine |
| 記事種別(英) |
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内容記述タイプ |
Other |
|
内容記述 |
Review |
| 抄録(英) |
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|
内容記述タイプ |
Other |
|
内容記述 |
In the small intestine, stem cells are considered to exist at the bottom of the crypt. Actively proliferatingtransitional cells supplied from stem cells are differentiated into two directions upward and downward. Upwardcells are differentiated into absorbing epithelial cells, goblet cells, and endocrine cells, and downwardcells differentiated into Paneth cells. However there are some difficulties to identify the stem cells becauseof their unique characteristics. At first, stem cells occur as actual stem cells and potential stem cells, andsecond, there is diversity in stem cells. Therefore, molecules suitable for a marker of small intestinal stemcells are necessary to distinguish "true" stem cells from others. Energetically searched for in recent years,Musashi-1, type 1A bone morphogenetic protein receptor (BMPR-1A), phospho-phosphatase and tensinhomolog deleted on chromosome ten( phospho-PTEN), doublecortin and calmodulin kinase-like-1( DCAMKL1),ephrin receptors( Eph receptors), integrins, and leucine-rich repeat-containing G protein-coupled receptor5 (Lgr5) are proposed. Among them, Musashi-1 draws attention as one of a candidate marker forsmall intestinal stem cells. We here introduce our reviews about expression of Musashi-1 and Hes1 proteinsin the small intestine, and would like to overview the way to identify the small intestinal stem cells. |
| 書誌情報 |
Dokkyo journal of medical sciences
巻 37,
号 1,
p. 41-46,
発行日 2010-03-25
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| ISSN |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
03855023 |
KJ00006372879.pdf (182.8 kB)
