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The concentration of SLPI in CVF and serumwere determined by ELISA. HIV-VL were determinedby an ultra sensitive PCR assay based NucliSens. Mann-Whitney\u0027s test and Kruskal Walls\u0027 s test and Spearman\u0027srank correlation coefficient were used for analyses.RESULTS:Samples were obtained from 39 HIV-1 infectedpregnant women, 10 HIV-1 infected non-pregnantwomen and 13 HIV-1 non-infected pregnant women.Eighty percent were not receiving antiretroviral therapy.HIV-VL was detectable in 85 % of the serum samples and44 % of the CVF samples in the HIV-1 infected pregnantwomen. It was found that some cases showed the higherHIV-VL in CVF than in serum which were not typical butdissociated. It meant that it required considering careful todecide the delivery mode. There was no correlation betweenHIV-VL and SLPI in CVF samples. The concentrationof SLPI in CVF was higher in the pregnant women anddecreasing depends on the progress of gestational weeks.CONCLUSION:SLPI in CVF might play an important roleof innate immune defense mechanism to protect HIV-1 infectionin the cervix in the pregnant women. The concentrationof SLPI in CVF could be an effected decision makerof the delivery mode in HIV infected mother with low HIVVL.", "subitem_description_type": "Other"}]}, "item_2_description_15": {"attribute_name": "表示順", "attribute_value_mlt": [{"subitem_description": "14", "subitem_description_type": "Other"}]}, "item_2_description_16": {"attribute_name": "アクセション番号", "attribute_value_mlt": [{"subitem_description": "KJ00007015881", "subitem_description_type": "Other"}]}, "item_2_description_8": {"attribute_name": "記事種別(日)", "attribute_value_mlt": [{"subitem_description": "原著", "subitem_description_type": "Other"}]}, "item_2_description_9": {"attribute_name": "記事種別(英)", "attribute_value_mlt": [{"subitem_description": "Original", "subitem_description_type": "Other"}]}, "item_2_source_id_1": {"attribute_name": "雑誌書誌ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00629581", "subitem_source_identifier_type": "NCID"}]}, "item_2_source_id_19": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "03855023", "subitem_source_identifier_type": "ISSN"}]}, "item_2_text_6": {"attribute_name": "著者所属(日)", "attribute_value_mlt": [{"subitem_text_value": "獨協医科大学産科婦人科学"}, {"subitem_text_value": "獨協医科大学産科婦人科学"}, {"subitem_text_value": "獨協医科大学産科婦人科学"}, {"subitem_text_value": "獨協医科大学産科婦人科学"}, {"subitem_text_value": "獨協医科大学産科婦人科学"}, {"subitem_text_value": "獨協医科大学産科婦人科学"}, {"subitem_text_value": "獨協医科大学産科婦人科学"}, {"subitem_text_value": "獨協医科大学産科婦人科学"}, {"subitem_text_value": "獨協医科大学産科婦人科学"}, {"subitem_text_value": "獨協医科大学産科婦人科学"}, {"subitem_text_value": "獨協医科大学産科婦人科学"}, {"subitem_text_value": "獨協医科大学産科婦人科学"}]}, "item_2_text_7": {"attribute_name": "著者所属(英)", "attribute_value_mlt": [{"subitem_text_language": "en", "subitem_text_value": "Department of Obstetrics and Gynecology, Dokkyo Medical University"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Obstetrics and Gynecology, Dokkyo Medical University"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Obstetrics and Gynecology, Dokkyo Medical University"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Obstetrics and Gynecology, Dokkyo Medical University"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Obstetrics and Gynecology, Dokkyo Medical University"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Obstetrics and Gynecology, Dokkyo Medical University"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Obstetrics and Gynecology, Dokkyo Medical University"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Obstetrics and Gynecology, Dokkyo Medical University"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Obstetrics and Gynecology, Dokkyo Medical University"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Obstetrics and Gynecology, Dokkyo Medical University"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Obstetrics and Gynecology, Dokkyo Medical University"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Obstetrics and Gynecology, Dokkyo Medical University"}]}, "item_2_title_3": {"attribute_name": "論文名よみ", "attribute_value_mlt": [{"subitem_title": "ニンプ ケッチュウ オヨビ ケイカン チツ ブンピツ エキ ニオケル HIV-1 ウイルス リョウ ト Secretory Leukocyte Protease Inhibitor チ ニ カンスル ケントウ : HIVボシ カンセン タイサク ノ カンテン ヨリ"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "大島, 教子"}, {"creatorName": "オオシマ, キョウコ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "4162", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "稲葉, 憲之"}, {"creatorName": "イナバ, ノリユキ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "4163", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "林田, 志峯"}, {"creatorName": "ハヤシダ, シホウ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "4164", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "根岸, 正実"}, {"creatorName": "ネギシ, マサミ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "4165", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "庄田, 亜紀子"}, {"creatorName": "ショウダ, アキコ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "4166", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "岡崎, 隆行"}, {"creatorName": "オカザキ, タカユキ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "4167", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "多田, 和美"}, {"creatorName": "タダ, カズミ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "4168", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "西川, 正能"}, {"creatorName": "ニシカワ, マサヨシ", "creatorNameLang": "ja-Kana"}], 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[{"creatorName": "Nishikawa, Masayoshi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "4181", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tadokoro, Nozomu", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "4182", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kitazawa, Masafumi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "4183", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Fukasawa, Ichio", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "4184", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Watanabe, Hiroshi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "4185", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-05-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "KJ00007015881.pdf", "filesize": [{"value": "355.8 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 355800.0, "url": {"label": "KJ00007015881.pdf", "url": "https://dmu.repo.nii.ac.jp/record/928/files/KJ00007015881.pdf"}, "version_id": "9302dcef-0eba-4544-9ccb-bb9fb4cf6135"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "HIV-1", "subitem_subject_scheme": "Other"}, {"subitem_subject": "子宮頚管・膣粘液", "subitem_subject_scheme": "Other"}, {"subitem_subject": "SLPI値", "subitem_subject_scheme": "Other"}, {"subitem_subject": "経膣分娩", "subitem_subject_scheme": "Other"}, {"subitem_subject": "母子感染", "subitem_subject_scheme": "Other"}, {"subitem_subject": "HIV-1 viral loads", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "CVF", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "SLPI", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "vaginal delivery", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "mother to child transmission", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "妊婦血中および頚管腟分泌液におけるHIV-1 ウイルス量とSecretory Leukocyte Protease Inhibitor 値に関する検討 : HIV 母子感染対策の観点より", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "妊婦血中および頚管腟分泌液におけるHIV-1 ウイルス量とSecretory Leukocyte Protease Inhibitor 値に関する検討 : HIV 母子感染対策の観点より"}, {"subitem_title": "Relationship Between Viral Load of Human Immunedificiency Virus Type 1( HIV-1) and Secretory Leukocyte Protease Inhibitor( SLPI) in Cervico-vaginal Fluid( CVF) and Serum in HIV-1 Infected Pregnant Women", "subitem_title_language": "en"}]}, "item_type_id": "2", "owner": "3", "path": ["57"], "permalink_uri": "https://dmu.repo.nii.ac.jp/records/928", "pubdate": {"attribute_name": "公開日", "attribute_value": "2017-05-24"}, "publish_date": "2017-05-24", "publish_status": "0", "recid": "928", "relation": {}, "relation_version_is_last": true, "title": ["妊婦血中および頚管腟分泌液におけるHIV-1 ウイルス量とSecretory Leukocyte Protease Inhibitor 値に関する検討 : HIV 母子感染対策の観点より"], "weko_shared_id": 3}
  1. Dokkyo Journal of Medical Sciences
  2. 38(1) 2011

妊婦血中および頚管腟分泌液におけるHIV-1 ウイルス量とSecretory Leukocyte Protease Inhibitor 値に関する検討 : HIV 母子感染対策の観点より

https://dmu.repo.nii.ac.jp/records/928
https://dmu.repo.nii.ac.jp/records/928
0ae24b91-fffd-4225-bb9c-a5fe7a2a55a1
名前 / ファイル ライセンス アクション
KJ00007015881.pdf KJ00007015881.pdf (355.8 kB)
Item type [ELS]学術雑誌論文 / Journal Article(1)
公開日 2017-05-24
タイトル
タイトル 妊婦血中および頚管腟分泌液におけるHIV-1 ウイルス量とSecretory Leukocyte Protease Inhibitor 値に関する検討 : HIV 母子感染対策の観点より
タイトル
言語 en
タイトル Relationship Between Viral Load of Human Immunedificiency Virus Type 1( HIV-1) and Secretory Leukocyte Protease Inhibitor( SLPI) in Cervico-vaginal Fluid( CVF) and Serum in HIV-1 Infected Pregnant Women
言語
言語 jpn
キーワード
主題 HIV-1
キーワード
主題 子宮頚管・膣粘液
キーワード
主題 SLPI値
キーワード
主題 経膣分娩
キーワード
主題 母子感染
キーワード
言語 en
主題 HIV-1 viral loads
キーワード
言語 en
主題 CVF
キーワード
言語 en
主題 SLPI
キーワード
言語 en
主題 vaginal delivery
キーワード
言語 en
主題 mother to child transmission
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
雑誌書誌ID
収録物識別子 AA00629581
論文名よみ
タイトル ニンプ ケッチュウ オヨビ ケイカン チツ ブンピツ エキ ニオケル HIV-1 ウイルス リョウ ト Secretory Leukocyte Protease Inhibitor チ ニ カンスル ケントウ : HIVボシ カンセン タイサク ノ カンテン ヨリ
著者 大島, 教子

× 大島, 教子

WEKO 4162

大島, 教子

ja-Kana オオシマ, キョウコ

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稲葉, 憲之

× 稲葉, 憲之

WEKO 4163

稲葉, 憲之

ja-Kana イナバ, ノリユキ

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林田, 志峯

× 林田, 志峯

WEKO 4164

林田, 志峯

ja-Kana ハヤシダ, シホウ

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根岸, 正実

× 根岸, 正実

WEKO 4165

根岸, 正実

ja-Kana ネギシ, マサミ

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庄田, 亜紀子

× 庄田, 亜紀子

WEKO 4166

庄田, 亜紀子

ja-Kana ショウダ, アキコ

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岡崎, 隆行

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WEKO 4167

岡崎, 隆行

ja-Kana オカザキ, タカユキ

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多田, 和美

× 多田, 和美

WEKO 4168

多田, 和美

ja-Kana タダ, カズミ

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西川, 正能

× 西川, 正能

WEKO 4169

西川, 正能

ja-Kana ニシカワ, マサヨシ

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田所, 望

× 田所, 望

WEKO 4170

田所, 望

ja-Kana タドコロ, ノゾム

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北澤, 正文

× 北澤, 正文

WEKO 4171

北澤, 正文

ja-Kana キタザワ, マサフミ

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深澤, 一雄

× 深澤, 一雄

WEKO 4172

深澤, 一雄

ja-Kana フカサワ, イチオ

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渡辺, 博

× 渡辺, 博

WEKO 4173

渡辺, 博

ja-Kana ワタナベ, ヒロシ

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Oshima, Kyoko

× Oshima, Kyoko

WEKO 4174

en Oshima, Kyoko

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Inaba, Noriyuki

× Inaba, Noriyuki

WEKO 4175

en Inaba, Noriyuki

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Hayashida, Shihou

× Hayashida, Shihou

WEKO 4176

en Hayashida, Shihou

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Negishi, Masami

× Negishi, Masami

WEKO 4177

en Negishi, Masami

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Shouda, Akiko

× Shouda, Akiko

WEKO 4178

en Shouda, Akiko

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Okazaki, Takayuki

× Okazaki, Takayuki

WEKO 4179

en Okazaki, Takayuki

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Tada, Kazumi

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WEKO 4180

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Nishikawa, Masayoshi

× Nishikawa, Masayoshi

WEKO 4181

en Nishikawa, Masayoshi

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Tadokoro, Nozomu

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WEKO 4182

en Tadokoro, Nozomu

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Kitazawa, Masafumi

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WEKO 4183

en Kitazawa, Masafumi

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Fukasawa, Ichio

× Fukasawa, Ichio

WEKO 4184

en Fukasawa, Ichio

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Watanabe, Hiroshi

× Watanabe, Hiroshi

WEKO 4185

en Watanabe, Hiroshi

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著者所属(日)
獨協医科大学産科婦人科学
著者所属(日)
獨協医科大学産科婦人科学
著者所属(日)
獨協医科大学産科婦人科学
著者所属(日)
獨協医科大学産科婦人科学
著者所属(日)
獨協医科大学産科婦人科学
著者所属(日)
獨協医科大学産科婦人科学
著者所属(日)
獨協医科大学産科婦人科学
著者所属(日)
獨協医科大学産科婦人科学
著者所属(日)
獨協医科大学産科婦人科学
著者所属(日)
獨協医科大学産科婦人科学
著者所属(日)
獨協医科大学産科婦人科学
著者所属(日)
獨協医科大学産科婦人科学
著者所属(英)
en
Department of Obstetrics and Gynecology, Dokkyo Medical University
著者所属(英)
en
Department of Obstetrics and Gynecology, Dokkyo Medical University
著者所属(英)
en
Department of Obstetrics and Gynecology, Dokkyo Medical University
著者所属(英)
en
Department of Obstetrics and Gynecology, Dokkyo Medical University
著者所属(英)
en
Department of Obstetrics and Gynecology, Dokkyo Medical University
著者所属(英)
en
Department of Obstetrics and Gynecology, Dokkyo Medical University
著者所属(英)
en
Department of Obstetrics and Gynecology, Dokkyo Medical University
著者所属(英)
en
Department of Obstetrics and Gynecology, Dokkyo Medical University
著者所属(英)
en
Department of Obstetrics and Gynecology, Dokkyo Medical University
著者所属(英)
en
Department of Obstetrics and Gynecology, Dokkyo Medical University
著者所属(英)
en
Department of Obstetrics and Gynecology, Dokkyo Medical University
著者所属(英)
en
Department of Obstetrics and Gynecology, Dokkyo Medical University
記事種別(日)
内容記述タイプ Other
内容記述 原著
記事種別(英)
内容記述タイプ Other
内容記述 Original
抄録(日)
内容記述タイプ Other
内容記述 ヒト免疫不全ウイルス1 型( human immunodeficiency virus type 1;HIV-1) キャリア妊婦は先進国では抗HIV 療法により母体血中HIV-1 ウイルス量( HIV-1 viral load;HIV-VL) が1,000 copies/ml 以下にコントロールされている事が多く,その場合,母子感染予防対策で講じられている選択的帝王切開分娩を回避し経腟分娩の選択が可能であるか新たな課題となってきた.今回,HIV-1感染妊婦の子宮頚管・腟粘液(cervicovaginalfluid;CVF) 中の自然感染防御因子の1 つであるsecretory leukocyte protease inhibitor (SLPI) とHIV-VL の関連を調査,経腟分娩時に軟産道となる子宮頚管局所のHIV-1 感染防御機序を検討した.方法は39名のHIV-1 感染妊婦( 米国人) のCVF 中および血中のSLPI 値とHIV-VL を測定,両者の関連を調べた.その結果,一部の症例ではCVF 中HIV-VL が血中HIV-VL より高値を示し,母体血中HIV-VL のみで分娩方法を判断する事に検討を要すると考えられた.一方,CVF 中SLPI 値は妊婦において非妊婦より高値を呈し,妊娠週数と共に減少する傾向を示した.CVF 中SLPI 値とHIV-VL に関連は認めなかった.CVF 中SLPI 値は局所(軟産道)の感染防御状態を反映している可能性があり,HIV-1 キャリア妊婦の経腟分娩の是非を検討する際に補助的診断として用いる事が可能か今後の更なる調査が必要である.
抄録(英)
内容記述タイプ Other
内容記述 To detect SLPI and HIV-1 RNA viralloads( HIV-VL) in CVF and blood of HIV-1 infected pregnantwomen with<1,000 copies/mL and to determine if itbecomes the decision maker of the delivery mode whetherelective cesarean session or vaginal delivery.STUDY DESIGN:CVF and blood samples were obtainedfrom HIV-1 infected women at the Jackson MemorialHospital in Miami in the United States and HIV-1 noninfectedpregnant women at the Dokkyo Medical UniversityHospital in 2005. The concentration of SLPI in CVF and serumwere determined by ELISA. HIV-VL were determinedby an ultra sensitive PCR assay based NucliSens. Mann-Whitney's test and Kruskal Walls' s test and Spearman'srank correlation coefficient were used for analyses.RESULTS:Samples were obtained from 39 HIV-1 infectedpregnant women, 10 HIV-1 infected non-pregnantwomen and 13 HIV-1 non-infected pregnant women.Eighty percent were not receiving antiretroviral therapy.HIV-VL was detectable in 85 % of the serum samples and44 % of the CVF samples in the HIV-1 infected pregnantwomen. It was found that some cases showed the higherHIV-VL in CVF than in serum which were not typical butdissociated. It meant that it required considering careful todecide the delivery mode. There was no correlation betweenHIV-VL and SLPI in CVF samples. The concentrationof SLPI in CVF was higher in the pregnant women anddecreasing depends on the progress of gestational weeks.CONCLUSION:SLPI in CVF might play an important roleof innate immune defense mechanism to protect HIV-1 infectionin the cervix in the pregnant women. The concentrationof SLPI in CVF could be an effected decision makerof the delivery mode in HIV infected mother with low HIVVL.
書誌情報 Dokkyo journal of medical sciences

巻 38, 号 1, p. 95-102, 発行日 2011-03-25
ISSN
収録物識別子 03855023
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