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  1. Dokkyo Journal of Medical Sciences
  2. 39(1) 2012

NMDA Component of the Excitatory Synaptic Transmission of Neurons Containing Serotonin or GABA in the Ventrolateral Subdivision of the Periaqueductal Gray Matter of Mouse

https://dmu.repo.nii.ac.jp/records/996
https://dmu.repo.nii.ac.jp/records/996
99d8f37e-aaab-49cb-9976-876075d4632b
名前 / ファイル ライセンス アクション
KJ00007845019.pdf KJ00007845019.pdf (261.6 kB)
Item type [ELS]学術雑誌論文 / Journal Article(1)
公開日 2017-05-24
タイトル
言語 en
タイトル NMDA Component of the Excitatory Synaptic Transmission of Neurons Containing Serotonin or GABA in the Ventrolateral Subdivision of the Periaqueductal Gray Matter of Mouse
言語
言語 eng
キーワード
言語 en
主題 Patch clamp recording
キーワード
言語 en
主題 single-cell RT-PCR
キーワード
言語 en
主題 sciatic nerve ligation
キーワード
言語 en
主題 NMDA
キーワード
言語 en
主題 PAG
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
雑誌書誌ID
収録物識別子 AA00629581
論文名よみ
タイトル NMDA Component of the Excitatory Synaptic Transmission of Neurons Containing Serotonin or GABA in the Ventrolateral Subdivision of the Periaqueductal Gray Matter of Mouse
著者 Shirakawa, Kenshu

× Shirakawa, Kenshu

WEKO 4637

en Shirakawa, Kenshu

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著者所属(英)
en
Department of Anesthesiology, Dokkyo Medical University School of Medicine
記事種別(英)
内容記述タイプ Other
内容記述 Original
抄録(英)
内容記述タイプ Other
内容記述 The midbrain periaqueductal gray( PAG) plays a crucial role in the descending pain modulating system.NMDA receptors (NMDARs) and serotonergic and GABAergic neurons have been identified in the PAG and are involved in the descending pain-modulating pathway. We characterized the NMDA component of the excitatory synaptic transmission within the ventrolateral subdivision of the PAG( vlPAG) using a whole cell patch clamp technique and then detected the expression of tryptophan hydroxylase (TPH), serotonin synthesizing enzyme, and glutamate decarboxylase (GAD), GABA synthesizing enzyme to understand thevlPAG intrinsic neurotransmission. The NMDA/non-NMDA ratio and the decay time constant of theNMDA component of the non-serotonergic GABAergic neurons were significantly larger than those of nonserotonergicnon-GABAergic neurons and serotonergic GABAergic neurons. This suggests that the non-serotonergic GABAergic neurons might play an important role in the descending pain modulating system originated from the PAG. The decay time constant of the NMDA component of the non-serotonergic non-GABAergic neuron was significantly greater in the mouse with partial sciatic nerve ligation compared with the control mouse. These results suggest that the subunit composition of the NMDAR in the non-serotonergicnon-GABAergic neurons change during neuropathic pain.
書誌情報 Dokkyo journal of medical sciences

巻 39, 号 1, p. 17-27, 発行日 2012-03-25
ISSN
収録物識別子 03855023
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