| Item type |
[ELS]学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-05-24 |
| タイトル |
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タイトル |
Diagnostic Validity of DNMT-1 and 3b Immunoreactivity in Non-neoplastic Epithelium of UC Patients with and Without Neoplasia |
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言語 |
en |
| 言語 |
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言語 |
eng |
| キーワード |
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言語 |
en |
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主題 |
DNA methyltransferase |
| キーワード |
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言語 |
en |
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主題 |
surveillance |
| キーワード |
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言語 |
en |
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主題 |
ulcerative colitis-associated neoplasia |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 雑誌書誌ID |
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収録物識別子 |
AA00629581 |
| 論文名よみ |
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タイトル |
Diagnostic Validity of DNMT-1 and 3b Immunoreactivity in Non-neoplastic Epithelium of UC Patients with and Without Neoplasia |
| 著者 |
Tanaka, Hiroyuki
Ichikawa, Kazuhito
Fujimori, Takahiro
Ohtake, Shinichiro
Yasuda, Yoshikazu
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| 著者所属(英) |
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en |
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Department of Surgical and Molecular Pathology, Dokkyo Medical University School of Medicine, Department of Surgery, Jichi Medical University School of Medicine |
| 著者所属(英) |
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en |
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Department of Surgical and Molecular Pathology, Dokkyo Medical University School of Medicine |
| 著者所属(英) |
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en |
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Department of Surgical and Molecular Pathology, Dokkyo Medical University School of Medicine |
| 著者所属(英) |
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en |
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Department of Surgical and Molecular Pathology, Dokkyo Medical University School of Medicine |
| 著者所属(英) |
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en |
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Department of Surgery, Jichi Medical University School of Medicine |
| 記事種別(英) |
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内容記述タイプ |
Other |
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内容記述 |
Original |
| 抄録(英) |
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内容記述タイプ |
Other |
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内容記述 |
It is important to improve the efficacy of surveillance in UC patients with neoplasia.In the present study, we assessed the cut-off value of expression of DNMT-1 and DNMT-3b expression in the non-neoplastic rectal epithelium of patients with long-standing and extensive UC. Sixty patients with long-standing and extensive UC participated in this study( 30 with colorectal neoplasia and 30 without). Immunohistochemical analysis was performed to determine the expression of DNMT-1 and 3b in non-neoplasticrectal epithelium of UC patients without neoplasia, and in non-neoplastic rectal epithelium of UC patients with neoplasia. The level of immunoreactive DNMT-1 and DNMT-3b expression was determined as the percentage of positive cells relative to the total number of cells counted under high power magnification.DNMT-1 and 3b expression in non-neoplastic rectal epithelium of UC patients with neoplasia (0.57, range0.53-0.63)(0.32, range 0.18-0.67) was higher than in the non-neoplastic epithelium of UC patients without neoplasia (0.41, range 0.25-0.54, P=.001)(0.0, range 0.0-0.13, P<.001). ROC curve analysis confirmed0.53 and 0.07 as the best DNMT-1 and DNMT-3b cut-off values for identifying individuals at increased risk of neoplasia( area under the curve=0.798 and 0.842, respectively). The cut-off value for DNMT-1 andDNMT-3b expression in non-neoplastic rectal epithelium is therefore an efficient predictor for the increased risk of UC-associated neoplasia. |
| 書誌情報 |
Dokkyo journal of medical sciences
巻 39,
号 1,
p. 29-35,
発行日 2012-03-25
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
03855023 |
KJ00007845699.pdf (192.0 kB)
