WEKO3
アイテム
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Beneficial Effects of Ischemic Preconditioning on Renal Hemodynamics in Ischemia-reperfused Rat Kidneys:Role of Two Nitric Oxide Synthase Isozymes in Ischemic Preconditioned Kidneys
https://dmu.repo.nii.ac.jp/records/5085
https://dmu.repo.nii.ac.jp/records/508506fba945-4513-459c-b7ea-3495be71b451
名前 / ファイル | ライセンス | アクション |
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DJMS-48-3-Tsuji-本文 (551.0 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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タイトル | ||||||
タイトル | Beneficial Effects of Ischemic Preconditioning on Renal Hemodynamics in Ischemia-reperfused Rat Kidneys:Role of Two Nitric Oxide Synthase Isozymes in Ischemic Preconditioned Kidneys | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | ischemia/reperfusion injury | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | ischemic preconditioning | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | kidney | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | rat | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | nitric oxide | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | renal blood flow | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | renal function | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Tsuji, Ei-ichi
× Tsuji, Ei-ichi× Ogawa, Toshihisa× Hayashibara, Noriaki× Kiyomatsu, Yuko× Yamaguchi, Nanaka× Nishio, Miki× Hoshi, Yukari× Fujiwara, Hanako× Yoshikata, Marie× Niwa, Takayoshi× Shirakawa, Kazuo |
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著者所属 | ||||||
Department of Breast Surgery, Dokkyo Medical University, Saitama Medical Center | ||||||
著者所属 | ||||||
Department of Breast Surgery, Dokkyo Medical University, Saitama Medical Center, Department of Breast and Endocrine Surgery, The University of Tokyo | ||||||
著者所属 | ||||||
Department of Breast Surgery, Dokkyo Medical University, Saitama Medical Center | ||||||
著者所属 | ||||||
Department of Breast Surgery, Dokkyo Medical University, Saitama Medical Center | ||||||
著者所属 | ||||||
Department of Breast Surgery, Dokkyo Medical University, Saitama Medical Center | ||||||
著者所属 | ||||||
Department of Breast Surgery, Dokkyo Medical University, Saitama Medical Center | ||||||
著者所属 | ||||||
Department of Breast Surgery, Dokkyo Medical University, Saitama Medical Center | ||||||
著者所属 | ||||||
Department of Breast Surgery, Dokkyo Medical University, Saitama Medical Center | ||||||
著者所属 | ||||||
Department of Breast Surgery, Dokkyo Medical University, Saitama Medical Center | ||||||
著者所属 | ||||||
Department of Breast and Endocrine Surgery, The University of Tokyo | ||||||
著者所属 | ||||||
Department of Breast Surgery, Dokkyo Medical University, Saitama Medical Center | ||||||
書誌情報 |
Dokkyo Journal of Medical Sciences 巻 48, 号 3, p. 151-159, 発行日 2021-10-25 |
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要旨 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Background:Ischemic preconditioning(IP)reduces oxidative damage during ischemia/reperfusion(I/R). IP elicits vasodilation following ischemia-perfusion in the microvasculature;however, there are few precise data concerning the rate of blood flow following IP-mediated I/R in tissues. Nitric oxide(NO)plays an important role in vasodilation;however, the type of nitric oxide synthase(NOS)expression that influences IP has not yet been determined. Therefore, the present study aimed to determine the effect of IP on renal hemodynamics during I/R in rat renal I/R models and analyze NOS expression in IP and IP-mediated reperfused kidneys. Methods:Renal hemodynamics, function and tissue NOS-enzyme expression were estimated in the following animal groups:Group1;bilateral renal ischemia for 30-min and reperfusion group, Group 2:40-min ischemia group, Group 3;5-min ischemia(IP)prior to 30-min ischemia, Group 4;40-min ischemia with IP, and sham group. Results:IP had beneficial effects on renal hemodynamics and function. We found that renal hemodynamics and glomerular filtration rate were significantly increased in IP-mediated kidneys. Western blotting analysis revealed increased expression levels of NOS-3 and NOS-2 in IP-mediated kidneys. Conclusion:These results suggest that IP-induced constitutive NOS may elicit a vasodilating effect in ischemia-reperfused rat kidneys. |
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記事種別 | ||||||
Original | ||||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | * Ei-ichi Tsuji & Toshihisa Ogawa Contributed equally to this work | |||||
出版者 | ||||||
出版者 | 獨協医学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 03855023 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00629581 |