| Item type |
学術雑誌論文 / Journal Article(1) |
| タイトル |
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タイトル |
Beneficial Effects of Ischemic Preconditioning on Renal Hemodynamics in Ischemia-reperfused Rat Kidneys：Role of Two Nitric Oxide Synthase Isozymes in Ischemic Preconditioned Kidneys |
| 言語 |
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|
言語 |
eng |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
ischemia/reperfusion injury |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
|
主題 |
ischemic preconditioning |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
|
主題 |
kidney |
| キーワード |
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|
言語 |
en |
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主題Scheme |
Other |
|
主題 |
rat |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
|
主題 |
nitric oxide |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
renal blood flow |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
renal function |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Tsuji, Ei-ichi
Ogawa, Toshihisa
Hayashibara, Noriaki
Kiyomatsu, Yuko
Yamaguchi, Nanaka
Nishio, Miki
Hoshi, Yukari
Fujiwara, Hanako
Yoshikata, Marie
Niwa, Takayoshi
Shirakawa, Kazuo
|
| 著者所属 |
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|
値 |
Department of Breast Surgery, Dokkyo Medical University, Saitama Medical Center |
| 著者所属 |
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値 |
Department of Breast Surgery, Dokkyo Medical University, Saitama Medical Center, Department of Breast and Endocrine Surgery, The University of Tokyo |
| 著者所属 |
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|
値 |
Department of Breast Surgery, Dokkyo Medical University, Saitama Medical Center |
| 著者所属 |
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|
値 |
Department of Breast Surgery, Dokkyo Medical University, Saitama Medical Center |
| 著者所属 |
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|
値 |
Department of Breast Surgery, Dokkyo Medical University, Saitama Medical Center |
| 著者所属 |
|
|
値 |
Department of Breast Surgery, Dokkyo Medical University, Saitama Medical Center |
| 著者所属 |
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|
値 |
Department of Breast Surgery, Dokkyo Medical University, Saitama Medical Center |
| 著者所属 |
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|
値 |
Department of Breast Surgery, Dokkyo Medical University, Saitama Medical Center |
| 著者所属 |
|
|
値 |
Department of Breast Surgery, Dokkyo Medical University, Saitama Medical Center |
| 著者所属 |
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値 |
Department of Breast and Endocrine Surgery, The University of Tokyo |
| 著者所属 |
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|
値 |
Department of Breast Surgery, Dokkyo Medical University, Saitama Medical Center |
| 書誌情報 |
Dokkyo Journal of Medical Sciences
巻 48,
号 3,
p. 151-159,
発行日 2021-10-25
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| 要旨 |
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内容記述タイプ |
Other |
|
内容記述 |
Background：Ischemic preconditioning（IP）reduces oxidative damage during ischemia/reperfusion（I/R）. IP elicits vasodilation following ischemia-perfusion in the microvasculature；however, there are few precise data concerning the rate of blood flow following IP-mediated I/R in tissues. Nitric oxide（NO）plays an important role in vasodilation；however, the type of nitric oxide synthase（NOS）expression that influences IP has not yet been determined. Therefore, the present study aimed to determine the effect of IP on renal hemodynamics during I/R in rat renal I/R models and analyze NOS expression in IP and IP-mediated reperfused kidneys.
Methods：Renal hemodynamics, function and tissue NOS-enzyme expression were estimated in the following animal groups：Group1；bilateral renal ischemia for 30-min and reperfusion group, Group 2：40-min ischemia group, Group 3；5-min ischemia（IP）prior to 30-min ischemia, Group 4；40-min ischemia with IP, and sham group.
Results：IP had beneficial effects on renal hemodynamics and function. We found that renal hemodynamics and glomerular filtration rate were significantly increased in IP-mediated kidneys. Western blotting analysis revealed increased expression levels of NOS-3 and NOS-2 in IP-mediated kidneys.
Conclusion：These results suggest that IP-induced constitutive NOS may elicit a vasodilating effect in ischemia-reperfused rat kidneys. |
| 記事種別 |
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値 |
Original |
| 内容記述 |
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内容記述タイプ |
Other |
|
内容記述 |
＊ Ei-ichi Tsuji & Toshihisa Ogawa Contributed equally to this work |
| 出版者 |
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出版者 |
獨協医学会 |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
03855023 |
| 書誌レコードID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA00629581 |
DJMS-48-3-Tsuji-本文 (551.0 kB)
