{"_buckets": {"deposit": "9dc21f33-cf64-46c1-afe4-bc0d9a1f51d0"}, "_deposit": {"created_by": 3, "id": "1001", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "1001"}, "status": "published"}, "_oai": {"id": "oai:dmu.repo.nii.ac.jp:00001001", "sets": ["61"]}, "author_link": ["4666", "4671", "4669", "4667", "4673", "4672", "4670", "4668"], "item_2_biblio_info_12": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2012-03-25", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "75", "bibliographicPageStart": "67", "bibliographicVolumeNumber": "39", "bibliographic_titles": [{"bibliographic_title": "Dokkyo journal of medical sciences"}]}]}, "item_2_description_10": {"attribute_name": "抄録(日)", "attribute_value_mlt": [{"subitem_description": "われわれは口腔扁平上皮癌の浸潤様式に対してはじめて三次元解析による検討を行ない,その有用性について報告してきた.今回は,癌の浸潤・転移において重要な役割を担う細胞外マトリックス分解酵素のうち,Matrix metalloproteinase-2 (MMP-2),MMP-9 およびMembrane type 1 matrix metalloproteinase(MT1-MMP)の発現と三次元解析による浸潤様式との関係について検討を行ったので報告する.対象は獨協医科大学病院口腔外科で加療した口腔扁平上皮癌一次症例175 例のうち,三次元解析が可能であった根治的手術症例31 例を用いた.MMP-2,MMP-9 およびMT1-MMP のそれぞれの発現陽性率は38.7%,67.7%,100%であった.非連続型は連続型に比較し,MMPs の発現頻度は高く,また発現部位は腫瘍細胞だけでなく,間質の細胞にも発現していた.非連続型はMMPs が単独で,あるいは相互に作用しあい,び慢性に浸潤することが示唆された.今回の検討により,MMPs の発現と三次元解析による浸潤様式は密接に関連し,両者とも口腔癌の治療法の決定や予後予測に有用であることが示された.", "subitem_description_type": "Other"}]}, "item_2_description_11": {"attribute_name": "抄録(英)", "attribute_value_mlt": [{"subitem_description": "We studied the mode of invasion of oral squamous cell carcinoma( OSCC) by three-dimensional( 3-D) analysis for the first time and reported its clinical usefulness. The purpose of this study is to discuss the relationship between the expression of matrix metalloproteinase (MMP)-2, MMP-9and membrane type 1-metalloproteinase( MT1-MMP) and the mode of invasion of OSCC by 3-D analysis. In this present31 of 175 patients with OSCC treated with curative surgery at first were able to be examined. The expression ofMMP-2, MMP-9 and MT1-MMP was examined by immunohistochemical techniques. The rate of MMP-2 expressionwas 38.7%, MMP-9 67.7 % and MT1-MMP 100 % . The rates of the expression of MMPs were significantly higher in discontinuous type than in continuous type. The positive expression of MMPs were detected not only in tumor cells but also in stromal cells in discontinuous type. These results indicate that MMPs contribute to the diffused invasion of OSCC with discontinuous type independently or mutually.In conclusion, the mode of invasion of OSCC by 3-Danalysis is closely related with the expression of MMPs and they can be useful to planning therapeutic strategy and predicting prognosis of the patient with OSCC.", "subitem_description_type": "Other"}]}, "item_2_description_15": {"attribute_name": "表示順", "attribute_value_mlt": [{"subitem_description": "9", "subitem_description_type": "Other"}]}, "item_2_description_16": {"attribute_name": "アクセション番号", "attribute_value_mlt": [{"subitem_description": "KJ00007847639", "subitem_description_type": "Other"}]}, "item_2_description_8": {"attribute_name": "記事種別(日)", "attribute_value_mlt": [{"subitem_description": "原著", "subitem_description_type": "Other"}]}, "item_2_description_9": {"attribute_name": "記事種別(英)", "attribute_value_mlt": [{"subitem_description": "Original", "subitem_description_type": "Other"}]}, "item_2_source_id_1": {"attribute_name": "雑誌書誌ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00629581", "subitem_source_identifier_type": "NCID"}]}, "item_2_source_id_19": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "03855023", "subitem_source_identifier_type": "ISSN"}]}, "item_2_text_6": {"attribute_name": "著者所属(日)", "attribute_value_mlt": [{"subitem_text_value": "宇都宮記念病院歯科口腔外科"}, {"subitem_text_value": "宇都宮記念病院歯科口腔外科"}, {"subitem_text_value": "宇都宮記念病院歯科口腔外科, いわせ歯科口腔外科耳鼻咽喉科クリニック"}, {"subitem_text_value": "獨協医科大学口腔外科学講座"}]}, "item_2_text_7": {"attribute_name": "著者所属(英)", "attribute_value_mlt": [{"subitem_text_language": "en", "subitem_text_value": "Dokkyo Division of Oral and Maxillofacial Surgery, Utsunomiya Memorial Hospital, Utsunomiya"}, {"subitem_text_language": "en", "subitem_text_value": "Dokkyo Division of Oral and Maxillofacial Surgery, Utsunomiya Memorial Hospital, Utsunomiya"}, {"subitem_text_language": "en", "subitem_text_value": "Dokkyo Division of Oral and Maxillofacial Surgery, Utsunomiya Memorial Hospital, Utsunomiya, Iwase Dental, Oral Surgery and Otolaryngology Clinic, Nikko"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Oral and Maxillofacial Surgery, Dokkyo Medical University School of Medicine"}]}, "item_2_title_3": {"attribute_name": "論文名よみ", "attribute_value_mlt": [{"subitem_title": "Three-dimensional Analysis the Mode of Invasion in Oral Squamous Cell Carcinoma and the Correlation Between its Results and the Expression of Matrix Metalloproteinases( MMPs)"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "城守, 美香"}, {"creatorName": "シロモリ, ミカ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "4666", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "佐々木, 忠昭"}, {"creatorName": "ササキ, タダアキ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "4667", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "岩瀬, 博建"}, {"creatorName": "イワセ, ヒロタテ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "4668", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "今井, 裕"}, {"creatorName": "イマイ, ユタカ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "4669", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shiromori, Mika", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "4670", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sasaki, Tadaaki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "4671", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Iwase, Hirotate", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "4672", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Imai, Yutaka", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "4673", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-05-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "KJ00007847639.pdf", "filesize": [{"value": "585.1 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 585100.0, "url": {"label": "KJ00007847639.pdf", "url": "https://dmu.repo.nii.ac.jp/record/1001/files/KJ00007847639.pdf"}, "version_id": "8403d9f9-9c5a-4fb2-b9e8-41ef00992a94"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "口腔癌", "subitem_subject_scheme": "Other"}, {"subitem_subject": "浸潤様式", "subitem_subject_scheme": "Other"}, {"subitem_subject": "三次元解析", "subitem_subject_scheme": "Other"}, {"subitem_subject": "予後", "subitem_subject_scheme": "Other"}, {"subitem_subject": "マトリックスメタロプロテアーゼ(matrix metalloproteinase)", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Oral Squamous Cell Carcinoma", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Mode of Invasion", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Three-dimensional analysis", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Prognosis", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Matrix Metalloproteinases", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "三次元解析による口腔扁平上皮癌の浸潤様式とMMP-2,MMP-9 およびMT1-MMP の発現に関する研究", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "三次元解析による口腔扁平上皮癌の浸潤様式とMMP-2,MMP-9 およびMT1-MMP の発現に関する研究"}, {"subitem_title": "サンジゲン カイセキ ニヨル コウクウ ヘンペイ ジョウヒ ガン ノ シツジュン ヨウシキ ト MMP-2, MMP-9 ノ ハツゲン ニ カンスル ケンキュウ", "subitem_title_language": "en"}]}, "item_type_id": "2", "owner": "3", "path": ["61"], "permalink_uri": "https://dmu.repo.nii.ac.jp/records/1001", "pubdate": {"attribute_name": "公開日", "attribute_value": "2017-05-24"}, "publish_date": "2017-05-24", "publish_status": "0", "recid": "1001", "relation": {}, "relation_version_is_last": true, "title": ["三次元解析による口腔扁平上皮癌の浸潤様式とMMP-2,MMP-9 およびMT1-MMP の発現に関する研究"], "weko_shared_id": 3}