| Item type |
[ELS]学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-05-24 |
| タイトル |
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タイトル |
IgG4-positive Plasmocytosis of Inflammatory Cell Spreading Pattern Revealed to Differentiation in Classic Oral Lichen Planus |
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言語 |
en |
| 言語 |
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言語 |
eng |
| キーワード |
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言語 |
en |
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主題 |
IgG4 related disease |
| キーワード |
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言語 |
en |
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主題 |
oral lichen planus |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 雑誌書誌ID |
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収録物識別子 |
AA00629581 |
| 論文名よみ |
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タイトル |
IgG4-positive Plasmocytosis of Inflammatory Cell Spreading Pattern Revealed to Differentiation in Classic Oral Lichen Planus |
| 著者 |
Maruoka, Takashi
Tomita, Shigeki
Ichikawa, Kazuhito
Kojima, Masaru
Hakata, Yuko
Imai, Yutaka
Imura, Johji
Fujimori, Takahiro
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| 著者所属(英) |
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en |
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Department of Surgical and Molecular Pathology, Dokkyo Medical University School of Medicine : Maruoka Clinic |
| 著者所属(英) |
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en |
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Department of Surgical and Molecular Pathology, Dokkyo Medical University School of Medicine |
| 著者所属(英) |
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en |
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Department of Surgical and Molecular Pathology, Dokkyo Medical University School of Medicine |
| 著者所属(英) |
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en |
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Department of Anatomical and Diagnostic Pathology, Dokkyo Medical University School of Medicine |
| 著者所属(英) |
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en |
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Department of Oral and Maxillofacial Surgery, Dokkyo Medical University School of Medicine |
| 著者所属(英) |
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en |
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Department of Oral and Maxillofacial Surgery, Dokkyo Medical University School of Medicine |
| 著者所属(英) |
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en |
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Department of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama |
| 著者所属(英) |
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en |
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Department of Surgical and Molecular Pathology, Dokkyo Medical University School of Medicine |
| 記事種別(英) |
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内容記述タイプ |
Other |
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内容記述 |
Original |
| 抄録(英) |
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内容記述タイプ |
Other |
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内容記述 |
Objective:Oral lichen planus( OLP) is a chronic inflammatory oral mucosal disease of unknown etiology.Due to similar histological features of OLP with other oral diseases. IgG4-related disease has been identified,but whether or not there are organ-specific characteristics related to the etiologic factors is still unknown.In the present study, we investigated the significance of IgG4-positive plasma cells as a marker for OLP.Methods:Biopsy specimens from 63 patients with white papules, erythema and erosive mucosa in theoral cavity were obtained. The lesions were evaluated for inflammatory cell spreading pattern classified ashorizontal superficial type and/or expanding type(s), for lymphoid-plasma cell markers (CD3, CD20,CD79a), Immunoglobulin G( IgG, IgG4) immunoreactivity, and for monoclonality.Results:In the horizontal superficial type with only CD3-positive lymphocytic inflammatory cells wererestricted to the epithelial layer of connective tissue without presence of IgG4-positive plasma cells. Lesionswere further demonstrated to contain CD3-, CD20- and CD79a-positive lympho-plasma cells with focal cytoplasmicIgG4 expression. However, in IgG4-rich cases, there were no monoclonality. The inflammatorycell spreading pattern differed significantly between the horizontal superficial type with only CD3-positivelymphoid cells and expanding types, and was significantly associated with IgG4-positive plasma cells.Conclusions:Detection of IgG4-positive plasma cells and inflammatory cell spreading pattern may beuseful for differential diagnosis and selection of treatable cases in OLP. |
| 書誌情報 |
Dokkyo journal of medical sciences
巻 40,
号 1,
p. 17-25,
発行日 2013-03-25
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
03855023 |
KJ00008416299.pdf (965.3 kB)
