| Item type |
[ELS]学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-05-24 |
| タイトル |
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タイトル |
Involvement of Bird-related IgG Antibodies in Interstitial Pneumonia |
|
言語 |
en |
| 言語 |
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言語 |
eng |
| キーワード |
|
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言語 |
en |
|
主題 |
idiopathic pulmonary fibrosis |
| キーワード |
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言語 |
en |
|
主題 |
chronic interstitial pneumonia |
| キーワード |
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|
言語 |
en |
|
主題 |
chronic hypersensitivity pneumonitis |
| キーワード |
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言語 |
en |
|
主題 |
bird-related hypersensitivity pneumonitis |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 雑誌書誌ID |
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収録物識別子 |
AA00629581 |
| 論文名よみ |
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タイトル |
Involvement of Bird-related IgG Antibodies in Interstitial Pneumonia |
| 著者 |
Mashio, Kazuki
Fukushima, Yasutsugu
Oomi, Fumito
Umetsu, Takafumi
Yoshida, Naruo
Ikeda, Naoya
Hirata, Hirokuni
Sugiyama, Kumiya
Fukuda, Takeshi
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| 著者所属(英) |
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en |
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Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University |
| 著者所属(英) |
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en |
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Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University |
| 著者所属(英) |
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en |
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Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University |
| 著者所属(英) |
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en |
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Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University |
| 著者所属(英) |
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en |
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Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University |
| 著者所属(英) |
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en |
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Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University |
| 著者所属(英) |
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en |
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Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University |
| 著者所属(英) |
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en |
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Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University |
| 著者所属(英) |
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en |
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Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University |
| 記事種別(英) |
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内容記述タイプ |
Other |
|
内容記述 |
ENG |
| 抄録(英) |
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内容記述タイプ |
Other |
|
内容記述 |
Background and Objective:Chronic interstitial pneumonia (IP) might include chronic hypersensitivity pneumonitis (HP) and chronic bird-related hypersensitivity pneumonitis (BRHP). A specific antigen is difficult to identify in these diseases, and such evidence would provide important clues suggesting a diagnosis of HP. In this study, we used an ImmunoCAP analysis system to measure specific IgG antibodies against pigeons and budgerigars in the sera of patients with IP and investigated the involvement of bird-related IgG antibodies in IP.Methods:The study group comprised 22 patients with idiopathic pulmonary fibrosis (IPF), 8 with chronic IP, 7 with subacute HP, 7 with chronic HP, and 10 with control diseases. All cases were diagnosed from 2000 through 2011 at the Institute of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University. Clinical features, results of laboratory examinations, and levels of serum IgG antibodies against pigeons and budgerigars were compared.Results:There were no significant differences among the disease groups in C-reactive protein, leukocyte count, lactate dehydrogenase, and the results of blood gas analysis. KL-6 and surfactant protein D were significantly higher in subacute HP and chronic HP. The levels of anti-pigeon IgG antibodies and anti-budgerigar IgG antibodies in each disease group were respectively as follows:IPF, 11.02±5.97 mg/l, 5.03±3.97 mg/l;chronic IP, 10.04±8.55 mg/l, 3.30±1.47 mg/l;subacute HP, 14.39±9.13 mg/l, 7.96±6.47 mg/l;chronic HP, 24.97±16.19 mg/l, 11.50±13.80 mg/l;and control diseases, 8.66±3.15 mg/l, 3.77±1.05 mg/l. The mean levels of anti-pigeon IgG antibodies and anti-budgerigar IgG antibodies were significantly higher in chronic HP. There was a positive correlation between anti-pigeon IgG antibodies and anti-budgerigar IgG antibodies (R2 = 0.715, p<0.001). Conclusions:In patients with clinically diagnosed chronic HP, high levels of anti-pigeon IgG antibodies or anti-budgerigar IgG antibodies were confirmed using an ImmunoCAP analysis system. In general, HP (especially chronic HP) is difficult to diagnose definitively, and this analysis system is expected to facilitate diagnosis. |
| 書誌情報 |
Dokkyo journal of medical sciences
巻 40,
号 1,
p. 39-46,
発行日 2013-03-25
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
03855023 |
KJ00008416759.pdf (381.9 kB)
