{"_buckets": {"deposit": "479ef2ee-7a27-4b8d-b0c6-e7d0ca01f420"}, "_deposit": {"created_by": 3, "id": "1147", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "1147"}, "status": "published"}, "_oai": {"id": "oai:dmu.repo.nii.ac.jp:00001147", "sets": ["67"]}, "author_link": ["5539", "5538", "5544", "5545", "5542", "5550", "5549", "5547", "5543", "5551", "5548", "5541", "5546", "5540"], "item_2_biblio_info_12": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2013-10-25", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "3", "bibliographicPageEnd": "174", "bibliographicPageStart": "169", "bibliographicVolumeNumber": "40", "bibliographic_titles": [{"bibliographic_title": "Dokkyo journal of medical sciences"}]}]}, "item_2_description_10": {"attribute_name": "抄録(日)", "attribute_value_mlt": [{"subitem_description": "要 旨 【目的】血管内皮機能障害は動脈硬化発症の端緒であり,糖尿病患者の血管障害を評価する上で非常に有用な生理学的機能検査である.そこで,実際の糖尿病診療をうけている患者の内皮機能を評価し,各種パラメータが与える影響を検討した.【方法】獨協医科大学内分泌代謝内科に通院している合併症のない2 型糖尿病患者に対して,臨床研究に同意した234名( 男性:133名,女性:101名)を対象として, 血管内皮機能を測定し,血糖値,血圧,脂質,喫煙歴,糖尿病罹患歴,Body mass index に対する相関を検討した.【結果】血糖コントロール(HbA1c),( 収縮期)血圧, 脂質(TG, LDL, non-HDL)に血管内皮機能は相関を認め,また糖尿病罹患歴にも相関を認めた.【結論】血管内皮機能検査で動脈硬化をより早期に拾い上げ,相関した因子を厳重に管理することで,糖尿病患者の動脈硬化性疾患の発症・進展阻止に十分な効果が期待できると考えられた.", "subitem_description_type": "Other"}]}, "item_2_description_11": {"attribute_name": "抄録(英)", "attribute_value_mlt": [{"subitem_description": "Background:The endothelium plays a major role in the regulation ofvascular tone. Endothelial dysfunction precedes apparentatherosclerosis in human. Type 2 diabetes mellitus(T2DM) is one of the most risk factors for arterioscleroticvascular disease, primarily, as the result of adverse changesin arteries. Therefore, identifying the factors related to impairedendothelial- dependent dilation with T2DM is crucialfor the purpose of prevention and/or treatment endothelialdysfunction.Objective:The aim of this study was to examine relevant factors associatedwith endothelial dysfunction in T2DM. In a total of234 diabetes patients, we assessed endothelial function byflow-mediated dilation and analyzed relevant factors effectedon endothelial function.Methods:We enrolled 234 T2DM patients attending Dokkyo MedicalUniversity Hospital( April from 2008 to February 2012).There were no changes in medications on hypertension, diabetes,and dyslipidemia during the previous 3 months. Thevascular response to reactive hyperemia in the brachial arterywas used for assessment of endothelial function(Flow-mediated dilation:FMD).Results:In this study, HbA1c, systolic blood pressure, LDL-cholesterol,Triglycerides, and duration of diabetes were negativelyassociated with % FMD by simple linear regressionanalysis. Furthermore, multivariate analysis revealed thatHbA1c, LDL-cholesterol, and duration of diabetes were alsoindependent predictors of the endothelial dysfunction.Conclusion:Our data showed that the tight management of relevantfactors related to impaired endothelial function in T2DM,might improve endothelium-dependent dilatation, suggestinga potential reduction in overall arteriosclerotic vasculardisease.", "subitem_description_type": "Other"}]}, "item_2_description_15": {"attribute_name": "表示順", "attribute_value_mlt": [{"subitem_description": "4", "subitem_description_type": "Other"}]}, "item_2_description_16": {"attribute_name": "アクセション番号", "attribute_value_mlt": [{"subitem_description": "KJ00008800559", "subitem_description_type": "Other"}]}, "item_2_description_8": {"attribute_name": "記事種別(日)", "attribute_value_mlt": [{"subitem_description": "原著", "subitem_description_type": "Other"}]}, "item_2_description_9": {"attribute_name": "記事種別(英)", "attribute_value_mlt": [{"subitem_description": "Original", "subitem_description_type": "Other"}]}, "item_2_source_id_1": {"attribute_name": "雑誌書誌ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00629581", "subitem_source_identifier_type": "NCID"}]}, "item_2_source_id_19": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "03855023", "subitem_source_identifier_type": "ISSN"}]}, "item_2_text_6": {"attribute_name": "著者所属(日)", "attribute_value_mlt": [{"subitem_text_value": "獨協医科大学内科学(内分泌代謝)"}, {"subitem_text_value": "獨協医科大学内科学(内分泌代謝)"}, {"subitem_text_value": "獨協医科大学内科学(内分泌代謝)"}, {"subitem_text_value": "獨協医科大学内科学(内分泌代謝)"}, {"subitem_text_value": "獨協医科大学内科学(内分泌代謝)"}, {"subitem_text_value": "獨協医科大学内科学(内分泌代謝)"}, {"subitem_text_value": "獨協医科大学内科学(内分泌代謝)"}]}, "item_2_text_7": {"attribute_name": "著者所属(英)", "attribute_value_mlt": [{"subitem_text_language": "en", "subitem_text_value": "Department of Endocrinology and Metabolism Dokkyo Medical University"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Endocrinology and Metabolism Dokkyo Medical University"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Endocrinology and Metabolism Dokkyo Medical University"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Endocrinology and Metabolism Dokkyo Medical University"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Endocrinology and Metabolism Dokkyo Medical University"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Endocrinology and Metabolism Dokkyo Medical University"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Endocrinology and Metabolism Dokkyo Medical University"}]}, "item_2_title_3": {"attribute_name": "論文名よみ", "attribute_value_mlt": [{"subitem_title": "2ガタ トウニョウビョウ カンジャ ノ ケッカン ナイヒ キノウ ヒョウカ オヨビ ソノ カンレン インシ ノ ケントウ"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "鈴木, 國弘"}, {"creatorName": "スズキ, クニヒロ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "5538", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "青木, 千枝"}, {"creatorName": "アオキ, チエ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "5539", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "飯嶋, 寿江"}, {"creatorName": "イイジマ, トシエ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "5540", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "田中, 精一"}, {"creatorName": "タナカ, セイイチ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "5541", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "二井谷, 舞"}, {"creatorName": "ニタニ, マイ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "5542", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "城島, 輝雄"}, {"creatorName": "ジョウジマ, テルオ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "5543", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "麻生, 好正"}, {"creatorName": "アソウ, ヨシマサ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "5544", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Suzuki, Kunihiro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "5545", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Aoki, Chie", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "5546", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Iijima, Toshie", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "5547", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tanaka, Seiichi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "5548", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Niitani, Mai", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "5549", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Jojima, Teruo", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "5550", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Aso, Yoshimasa", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "5551", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-05-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "KJ00008800559.pdf", "filesize": [{"value": "302.6 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 302600.0, "url": {"label": "KJ00008800559.pdf", "url": 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