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Failure of Growth Hormone Therapy in a Girl with Growth Hormone Deficiency and Steroid-induced Growth Failure Caused by Prednisolone Administration
https://dmu.repo.nii.ac.jp/records/123
https://dmu.repo.nii.ac.jp/records/1238c9e0c72-aa4d-4b4f-9d95-51645ce14f4d
名前 / ファイル | ライセンス | アクション |
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Item type | [ELS]学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-05-24 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Failure of Growth Hormone Therapy in a Girl with Growth Hormone Deficiency and Steroid-induced Growth Failure Caused by Prednisolone Administration | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題 | glucocorticoids | |||||
キーワード | ||||||
言語 | en | |||||
主題 | growth hormone deficiency | |||||
キーワード | ||||||
言語 | en | |||||
主題 | growth hormone therapy | |||||
キーワード | ||||||
言語 | en | |||||
主題 | lupus nephritis short stature | |||||
キーワード | ||||||
言語 | en | |||||
主題 | steroid-induced growth failure | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
雑誌書誌ID | ||||||
収録物識別子 | AA00629581 | |||||
論文名よみ | ||||||
タイトル | Failure of Growth Hormone Therapy in a Girl with Growth Hormone Deficiency and Steroid-induced Growth Failure Caused by Prednisolone Administration | |||||
著者 |
Kano, Kenichi
× Kano, Kenichi× Nishikura, Kiyoshi× Yamada, Yumi× Arisaka, Osamu |
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著者所属(英) | ||||||
en | ||||||
Division of Endocrinology, Department of Pediatrics, Dokkyo University School of Medicine | ||||||
著者所属(英) | ||||||
en | ||||||
Division of Endocrinology, Department of Pediatrics, Dokkyo University School of Medicine | ||||||
著者所属(英) | ||||||
en | ||||||
Division of Endocrinology, Department of Pediatrics, Dokkyo University School of Medicine | ||||||
著者所属(英) | ||||||
en | ||||||
Division of Endocrinology, Department of Pediatrics, Dokkyo University School of Medicine | ||||||
記事種別(日) | ||||||
内容記述タイプ | Other | |||||
内容記述 | 症例報告 | |||||
記事種別(英) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Case Report | |||||
抄録(英) | ||||||
内容記述タイプ | Other | |||||
内容記述 | We administered recombinant growth hormone (rGH) to a girl with systemic lupus erythematosus (SLE) complicated by steroid-induced growth failure and GH deficiency. However, the rGH therapy, which she underwent for 14 months, was not effective. The patient was diagnosed as SLE when she was 4 years and 10 months old, and her height before undergoing prednisolone was -1.0 SD score (SDS). She was treated with prednisolone (0.4-0.5 mg/kg/day) for a prolonged period. She was referred to us at 9 years of age because of persistent proteinuria that had begun when she was 7 years and 8 months old. We performed a renal biopsy (WHO SLE IIIA type) and noticed steroid-induced growth failure (-4.2 SDS), delay of bone maturation (5 years of age) and a low response to GH in the arginine and clonizine-loading test. We prescribed rGH therapy (0.175 mg/kg/week) and attempted to decrease prednisolone by administering cyclosporin A or mizolibine. However, prednisolone could not be decreased to less than 0.35 mg/kg/day for a long period. GH therapy for 14 months increased her height by only 2.8 cm (-4.4 SDS). The observations made in this SLE patient are consistent with those of Rivkees et al., who reported that when the prednisolone dose is greater than 0.35 mg/kg/day, rGH therapy does not increase the linear growth rate. | |||||
書誌情報 |
Dokkyo journal of medical sciences 巻 30, 号 1, p. 93-96, 発行日 2003-03-25 |
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ISSN | ||||||
収録物識別子 | 03855023 |