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  1. Dokkyo Journal of Medical Sciences
  2. 30(1) 2003

Failure of Growth Hormone Therapy in a Girl with Growth Hormone Deficiency and Steroid-induced Growth Failure Caused by Prednisolone Administration

https://dmu.repo.nii.ac.jp/records/123
https://dmu.repo.nii.ac.jp/records/123
8c9e0c72-aa4d-4b4f-9d95-51645ce14f4d
名前 / ファイル ライセンス アクション
KJ00000010454.pdf KJ00000010454.pdf (339.5 kB)
Item type [ELS]学術雑誌論文 / Journal Article(1)
公開日 2017-05-24
タイトル
タイトル Failure of Growth Hormone Therapy in a Girl with Growth Hormone Deficiency and Steroid-induced Growth Failure Caused by Prednisolone Administration
言語 en
言語
言語 eng
キーワード
言語 en
主題 glucocorticoids
キーワード
言語 en
主題 growth hormone deficiency
キーワード
言語 en
主題 growth hormone therapy
キーワード
言語 en
主題 lupus nephritis short stature
キーワード
言語 en
主題 steroid-induced growth failure
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
雑誌書誌ID
収録物識別子 AA00629581
論文名よみ
タイトル Failure of Growth Hormone Therapy in a Girl with Growth Hormone Deficiency and Steroid-induced Growth Failure Caused by Prednisolone Administration
著者 Kano, Kenichi

× Kano, Kenichi

en Kano, Kenichi

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Nishikura, Kiyoshi

× Nishikura, Kiyoshi

en Nishikura, Kiyoshi

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Yamada, Yumi

× Yamada, Yumi

en Yamada, Yumi

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Arisaka, Osamu

× Arisaka, Osamu

en Arisaka, Osamu

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著者所属(英)
en
Division of Endocrinology, Department of Pediatrics, Dokkyo University School of Medicine
著者所属(英)
en
Division of Endocrinology, Department of Pediatrics, Dokkyo University School of Medicine
著者所属(英)
en
Division of Endocrinology, Department of Pediatrics, Dokkyo University School of Medicine
著者所属(英)
en
Division of Endocrinology, Department of Pediatrics, Dokkyo University School of Medicine
記事種別(日)
内容記述タイプ Other
内容記述 症例報告
記事種別(英)
内容記述タイプ Other
内容記述 Case Report
抄録(英)
内容記述タイプ Other
内容記述 We administered recombinant growth hormone (rGH) to a girl with systemic lupus erythematosus (SLE) complicated by steroid-induced growth failure and GH deficiency. However, the rGH therapy, which she underwent for 14 months, was not effective. The patient was diagnosed as SLE when she was 4 years and 10 months old, and her height before undergoing prednisolone was -1.0 SD score (SDS). She was treated with prednisolone (0.4-0.5 mg/kg/day) for a prolonged period. She was referred to us at 9 years of age because of persistent proteinuria that had begun when she was 7 years and 8 months old. We performed a renal biopsy (WHO SLE IIIA type) and noticed steroid-induced growth failure (-4.2 SDS), delay of bone maturation (5 years of age) and a low response to GH in the arginine and clonizine-loading test. We prescribed rGH therapy (0.175 mg/kg/week) and attempted to decrease prednisolone by administering cyclosporin A or mizolibine. However, prednisolone could not be decreased to less than 0.35 mg/kg/day for a long period. GH therapy for 14 months increased her height by only 2.8 cm (-4.4 SDS). The observations made in this SLE patient are consistent with those of Rivkees et al., who reported that when the prednisolone dose is greater than 0.35 mg/kg/day, rGH therapy does not increase the linear growth rate.
書誌情報 Dokkyo journal of medical sciences

巻 30, 号 1, p. 93-96, 発行日 2003-03-25
ISSN
収録物識別子タイプ ISSN
収録物識別子 03855023
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