| Item type |
[ELS]学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-05-24 |
| タイトル |
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タイトル |
Failure of Growth Hormone Therapy in a Girl with Growth Hormone Deficiency and Steroid-induced Growth Failure Caused by Prednisolone Administration |
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言語 |
en |
| 言語 |
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|
言語 |
eng |
| キーワード |
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言語 |
en |
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主題 |
glucocorticoids |
| キーワード |
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言語 |
en |
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主題 |
growth hormone deficiency |
| キーワード |
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言語 |
en |
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主題 |
growth hormone therapy |
| キーワード |
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言語 |
en |
|
主題 |
lupus nephritis short stature |
| キーワード |
|
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言語 |
en |
|
主題 |
steroid-induced growth failure |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 雑誌書誌ID |
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収録物識別子 |
AA00629581 |
| 論文名よみ |
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タイトル |
Failure of Growth Hormone Therapy in a Girl with Growth Hormone Deficiency and Steroid-induced Growth Failure Caused by Prednisolone Administration |
| 著者 |
Kano, Kenichi
Nishikura, Kiyoshi
Yamada, Yumi
Arisaka, Osamu
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| 著者所属(英) |
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en |
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Division of Endocrinology, Department of Pediatrics, Dokkyo University School of Medicine |
| 著者所属(英) |
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en |
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Division of Endocrinology, Department of Pediatrics, Dokkyo University School of Medicine |
| 著者所属(英) |
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en |
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Division of Endocrinology, Department of Pediatrics, Dokkyo University School of Medicine |
| 著者所属(英) |
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en |
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Division of Endocrinology, Department of Pediatrics, Dokkyo University School of Medicine |
| 記事種別(日) |
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内容記述タイプ |
Other |
|
内容記述 |
症例報告 |
| 記事種別(英) |
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内容記述タイプ |
Other |
|
内容記述 |
Case Report |
| 抄録(英) |
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内容記述タイプ |
Other |
|
内容記述 |
We administered recombinant growth hormone (rGH) to a girl with systemic lupus erythematosus (SLE) complicated by steroid-induced growth failure and GH deficiency. However, the rGH therapy, which she underwent for 14 months, was not effective. The patient was diagnosed as SLE when she was 4 years and 10 months old, and her height before undergoing prednisolone was -1.0 SD score (SDS). She was treated with prednisolone (0.4-0.5 mg/kg/day) for a prolonged period. She was referred to us at 9 years of age because of persistent proteinuria that had begun when she was 7 years and 8 months old. We performed a renal biopsy (WHO SLE IIIA type) and noticed steroid-induced growth failure (-4.2 SDS), delay of bone maturation (5 years of age) and a low response to GH in the arginine and clonizine-loading test. We prescribed rGH therapy (0.175 mg/kg/week) and attempted to decrease prednisolone by administering cyclosporin A or mizolibine. However, prednisolone could not be decreased to less than 0.35 mg/kg/day for a long period. GH therapy for 14 months increased her height by only 2.8 cm (-4.4 SDS). The observations made in this SLE patient are consistent with those of Rivkees et al., who reported that when the prednisolone dose is greater than 0.35 mg/kg/day, rGH therapy does not increase the linear growth rate. |
| 書誌情報 |
Dokkyo journal of medical sciences
巻 30,
号 1,
p. 93-96,
発行日 2003-03-25
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
03855023 |
KJ00000010454.pdf (339.5 kB)
