| Item type |
[ELS]学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-05-24 |
| タイトル |
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タイトル |
Prostaglandin D_2 Augments Low-dose Antigen-induced Th2 Type Airway Inflammation in Mice |
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言語 |
en |
| 言語 |
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言語 |
eng |
| キーワード |
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言語 |
en |
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主題 |
Th2 |
| キーワード |
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言語 |
en |
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主題 |
prostaglandin D_2 |
| キーワード |
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言語 |
en |
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主題 |
MDC |
| キーワード |
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言語 |
en |
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主題 |
bronchial asthma |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 雑誌書誌ID |
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収録物識別子 |
AA00629581 |
| 論文名よみ |
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タイトル |
Prostaglandin D_2 Augments Low-dose Antigen-induced Th2 Type Airway Inflammation in Mice |
| 著者 |
Honda, Kyoko
Hirata, Hirokuni
Eda, Fukiko
Fukushima, Fumiya
Yamaguchi, Bunpei
Arima, Masafumi
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| 著者所属(英) |
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en |
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Department of Pulmonary Medical and Clinical Immunology, Dokkyo University School of Medicine |
| 著者所属(英) |
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en |
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Department of Pulmonary Medical and Clinical Immunology, Dokkyo University School of Medicine |
| 著者所属(英) |
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en |
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Department of Pulmonary Medical and Clinical Immunology, Dokkyo University School of Medicine |
| 著者所属(英) |
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en |
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Department of Pulmonary Medical and Clinical Immunology, Dokkyo University School of Medicine |
| 著者所属(英) |
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en |
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Department of Pulmonary Medical and Clinical Immunology, Dokkyo University School of Medicine |
| 著者所属(英) |
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en |
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Department of Pulmonary Medical and Clinical Immunology, Dokkyo University School of Medicine |
| 記事種別(英) |
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内容記述タイプ |
Other |
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内容記述 |
Original |
| 抄録(英) |
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内容記述タイプ |
Other |
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内容記述 |
Prostaglandin D_2 (PGD_2), a mast cell-derived lipid mediator is detected in lage amounts in airways of asthmatics, but its role of largely unkown. To clarify the role of PGD_2 in Th2-type airway inflammation which characterizes asthma, we studied the effects of aerosolized PGD_2 on the inflammatory response to a low-dose antien challenge in airways of mice. Mice sensitized with ovalbumin (OVA) were challenged with a conventional-dose (1%) or a low dose (0.1%) aerosolized OVA. Mice received low - dose OVA challenge were pretreated with aerosolized PGD_2 (10^<-3>M) (PGD_2 plus low-dose OVA mice) or saline (low-dose OVA alone mice) 24 hrs before the OVA challenge. Some mice were pretreated with PGD_2 but challenged with saline (PGD_2 alone mice). Airway inflammation was evaluated by the numbers of eosinophils, lymphocytes and macrophages in bronchoalveolar lavage fluid. The degree of airway inflammation in the PGD_2 alone mice and the low-dose OVA alone mice were only marginal. However, the PGD_2 plus low-dose OVA mice displayed a similar degree of airway inflammation with mice received conventional-dose OVA challenge. Levels of interleukin (IL)-4 and IL-5 were significantly increased in the PGD_2 plus low-dose OVA mice than the low-dose OVA alone mice. PGD_2 (10^<-9>-10^<-5> M) did not affect the Th2-type cytokine production by OVA specific T cells in response to OVA stimulation in vitro. Immunohistochemical analysis of lung tissue revealed that airway epithelium of the PGD_2 plus low-dose OVA alone mice were strongly stained with monoclonal antibody against macrophage-derived chemokine (MDC), a Th2 cell-specific chemokine. These results suggest that PGD_2 augments Th2 cell -type airway inflammation via epithelial experssion of MDC. |
| 書誌情報 |
Dokkyo journal of medical sciences
巻 30,
号 2,
p. 141-151,
発行日 2003-07-25
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
03855023 |
KJ00000010469.pdf (1.3 MB)
