{"_buckets": {"deposit": "de758d82-cad2-4106-a59e-bcd90fa795fc"}, "_deposit": {"created_by": 3, "id": "138", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "138"}, "status": "published"}, "_oai": {"id": "oai:dmu.repo.nii.ac.jp:00000138", "sets": ["26"]}, "author_link": ["436", "434", "433", "438", "437", "435"], "item_2_biblio_info_12": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2003-07-25", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "2", "bibliographicPageEnd": "151", "bibliographicPageStart": "141", "bibliographicVolumeNumber": "30", "bibliographic_titles": [{"bibliographic_title": "Dokkyo journal of medical sciences"}]}]}, "item_2_description_11": {"attribute_name": "抄録(英)", "attribute_value_mlt": [{"subitem_description": "Prostaglandin D_2 (PGD_2), a mast cell-derived lipid mediator is detected in lage amounts in airways of asthmatics, but its role of largely unkown. To clarify the role of PGD_2 in Th2-type airway inflammation which characterizes asthma, we studied the effects of aerosolized PGD_2 on the inflammatory response to a low-dose antien challenge in airways of mice. Mice sensitized with ovalbumin (OVA) were challenged with a conventional-dose (1%) or a low dose (0.1%) aerosolized OVA. Mice received low - dose OVA challenge were pretreated with aerosolized PGD_2 (10^\u003c-3\u003eM) (PGD_2 plus low-dose OVA mice) or saline (low-dose OVA alone mice) 24 hrs before the OVA challenge. Some mice were pretreated with PGD_2 but challenged with saline (PGD_2 alone mice). Airway inflammation was evaluated by the numbers of eosinophils, lymphocytes and macrophages in bronchoalveolar lavage fluid. The degree of airway inflammation in the PGD_2 alone mice and the low-dose OVA alone mice were only marginal. However, the PGD_2 plus low-dose OVA mice displayed a similar degree of airway inflammation with mice received conventional-dose OVA challenge. Levels of interleukin (IL)-4 and IL-5 were significantly increased in the PGD_2 plus low-dose OVA mice than the low-dose OVA alone mice. PGD_2 (10^\u003c-9\u003e-10^\u003c-5\u003e M) did not affect the Th2-type cytokine production by OVA specific T cells in response to OVA stimulation in vitro. Immunohistochemical analysis of lung tissue revealed that airway epithelium of the PGD_2 plus low-dose OVA alone mice were strongly stained with monoclonal antibody against macrophage-derived chemokine (MDC), a Th2 cell-specific chemokine. These results suggest that PGD_2 augments Th2 cell -type airway inflammation via epithelial experssion of MDC.", "subitem_description_type": "Other"}]}, "item_2_description_15": {"attribute_name": "表示順", "attribute_value_mlt": [{"subitem_description": "5", "subitem_description_type": "Other"}]}, "item_2_description_16": {"attribute_name": "アクセション番号", "attribute_value_mlt": [{"subitem_description": "KJ00000010469", "subitem_description_type": "Other"}]}, "item_2_description_9": {"attribute_name": "記事種別(英)", "attribute_value_mlt": [{"subitem_description": "Original", "subitem_description_type": "Other"}]}, "item_2_source_id_1": {"attribute_name": "雑誌書誌ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00629581", "subitem_source_identifier_type": "NCID"}]}, "item_2_source_id_19": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "03855023", "subitem_source_identifier_type": "ISSN"}]}, "item_2_text_7": {"attribute_name": "著者所属(英)", "attribute_value_mlt": [{"subitem_text_language": "en", "subitem_text_value": "Department of Pulmonary Medical and Clinical Immunology, Dokkyo University School of Medicine"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Pulmonary Medical and Clinical Immunology, Dokkyo University School of Medicine"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Pulmonary Medical and Clinical Immunology, Dokkyo University School of Medicine"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Pulmonary Medical and Clinical Immunology, Dokkyo University School of Medicine"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Pulmonary Medical and Clinical Immunology, Dokkyo University School of Medicine"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Pulmonary Medical and Clinical Immunology, Dokkyo University School of Medicine"}]}, "item_2_title_3": {"attribute_name": "論文名よみ", "attribute_value_mlt": [{"subitem_title": "Prostaglandin D_2 Augments Low-dose Antigen-induced Th2 Type Airway Inflammation in Mice"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Honda, Kyoko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "433", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hirata, Hirokuni", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "434", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Eda, Fukiko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "435", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Fukushima, Fumiya", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "436", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yamaguchi, Bunpei", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "437", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Arima, Masafumi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "438", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-05-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "KJ00000010469.pdf", "filesize": [{"value": "1.3 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1300000.0, "url": {"label": "KJ00000010469.pdf", "url": "https://dmu.repo.nii.ac.jp/record/138/files/KJ00000010469.pdf"}, "version_id": "164ba1ac-f473-4c0d-bcf8-db39a5ca7e93"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Th2", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "prostaglandin D_2", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "MDC", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "bronchial asthma", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Prostaglandin D_2 Augments Low-dose Antigen-induced Th2 Type Airway Inflammation in Mice", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Prostaglandin D_2 Augments Low-dose Antigen-induced Th2 Type Airway Inflammation in Mice", "subitem_title_language": "en"}]}, "item_type_id": "2", "owner": "3", "path": ["26"], "permalink_uri": "https://dmu.repo.nii.ac.jp/records/138", "pubdate": {"attribute_name": "公開日", "attribute_value": "2017-05-24"}, "publish_date": "2017-05-24", "publish_status": "0", "recid": "138", "relation": {}, "relation_version_is_last": true, "title": ["Prostaglandin D_2 Augments Low-dose Antigen-induced Th2 Type Airway Inflammation in Mice"], "weko_shared_id": 3}