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  1. Dokkyo Journal of Medical Sciences
  2. 30(2) 2003

Prostaglandin D_2 Augments Low-dose Antigen-induced Th2 Type Airway Inflammation in Mice

https://dmu.repo.nii.ac.jp/records/138
https://dmu.repo.nii.ac.jp/records/138
7207ded3-fe37-467b-b60b-3ec1e81d125e
名前 / ファイル ライセンス アクション
KJ00000010469.pdf KJ00000010469.pdf (1.3 MB)
Item type [ELS]学術雑誌論文 / Journal Article(1)
公開日 2017-05-24
タイトル
タイトル Prostaglandin D_2 Augments Low-dose Antigen-induced Th2 Type Airway Inflammation in Mice
言語 en
言語
言語 eng
キーワード
言語 en
主題 Th2
キーワード
言語 en
主題 prostaglandin D_2
キーワード
言語 en
主題 MDC
キーワード
言語 en
主題 bronchial asthma
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
雑誌書誌ID
収録物識別子 AA00629581
論文名よみ
タイトル Prostaglandin D_2 Augments Low-dose Antigen-induced Th2 Type Airway Inflammation in Mice
著者 Honda, Kyoko

× Honda, Kyoko

en Honda, Kyoko

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Hirata, Hirokuni

× Hirata, Hirokuni

en Hirata, Hirokuni

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Eda, Fukiko

× Eda, Fukiko

en Eda, Fukiko

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Fukushima, Fumiya

× Fukushima, Fumiya

en Fukushima, Fumiya

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Yamaguchi, Bunpei

× Yamaguchi, Bunpei

en Yamaguchi, Bunpei

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Arima, Masafumi

× Arima, Masafumi

en Arima, Masafumi

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著者所属(英)
en
Department of Pulmonary Medical and Clinical Immunology, Dokkyo University School of Medicine
著者所属(英)
en
Department of Pulmonary Medical and Clinical Immunology, Dokkyo University School of Medicine
著者所属(英)
en
Department of Pulmonary Medical and Clinical Immunology, Dokkyo University School of Medicine
著者所属(英)
en
Department of Pulmonary Medical and Clinical Immunology, Dokkyo University School of Medicine
著者所属(英)
en
Department of Pulmonary Medical and Clinical Immunology, Dokkyo University School of Medicine
著者所属(英)
en
Department of Pulmonary Medical and Clinical Immunology, Dokkyo University School of Medicine
記事種別(英)
内容記述タイプ Other
内容記述 Original
抄録(英)
内容記述タイプ Other
内容記述 Prostaglandin D_2 (PGD_2), a mast cell-derived lipid mediator is detected in lage amounts in airways of asthmatics, but its role of largely unkown. To clarify the role of PGD_2 in Th2-type airway inflammation which characterizes asthma, we studied the effects of aerosolized PGD_2 on the inflammatory response to a low-dose antien challenge in airways of mice. Mice sensitized with ovalbumin (OVA) were challenged with a conventional-dose (1%) or a low dose (0.1%) aerosolized OVA. Mice received low - dose OVA challenge were pretreated with aerosolized PGD_2 (10^<-3>M) (PGD_2 plus low-dose OVA mice) or saline (low-dose OVA alone mice) 24 hrs before the OVA challenge. Some mice were pretreated with PGD_2 but challenged with saline (PGD_2 alone mice). Airway inflammation was evaluated by the numbers of eosinophils, lymphocytes and macrophages in bronchoalveolar lavage fluid. The degree of airway inflammation in the PGD_2 alone mice and the low-dose OVA alone mice were only marginal. However, the PGD_2 plus low-dose OVA mice displayed a similar degree of airway inflammation with mice received conventional-dose OVA challenge. Levels of interleukin (IL)-4 and IL-5 were significantly increased in the PGD_2 plus low-dose OVA mice than the low-dose OVA alone mice. PGD_2 (10^<-9>-10^<-5> M) did not affect the Th2-type cytokine production by OVA specific T cells in response to OVA stimulation in vitro. Immunohistochemical analysis of lung tissue revealed that airway epithelium of the PGD_2 plus low-dose OVA alone mice were strongly stained with monoclonal antibody against macrophage-derived chemokine (MDC), a Th2 cell-specific chemokine. These results suggest that PGD_2 augments Th2 cell -type airway inflammation via epithelial experssion of MDC.
書誌情報 Dokkyo journal of medical sciences

巻 30, 号 2, p. 141-151, 発行日 2003-07-25
ISSN
収録物識別子タイプ ISSN
収録物識別子 03855023
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