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Prostaglandin D_2 Augments Low-dose Antigen-induced Th2 Type Airway Inflammation in Mice
https://dmu.repo.nii.ac.jp/records/138
https://dmu.repo.nii.ac.jp/records/1387207ded3-fe37-467b-b60b-3ec1e81d125e
名前 / ファイル | ライセンス | アクション |
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Item type | [ELS]学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-05-24 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Prostaglandin D_2 Augments Low-dose Antigen-induced Th2 Type Airway Inflammation in Mice | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題 | Th2 | |||||
キーワード | ||||||
言語 | en | |||||
主題 | prostaglandin D_2 | |||||
キーワード | ||||||
言語 | en | |||||
主題 | MDC | |||||
キーワード | ||||||
言語 | en | |||||
主題 | bronchial asthma | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
雑誌書誌ID | ||||||
収録物識別子 | AA00629581 | |||||
論文名よみ | ||||||
タイトル | Prostaglandin D_2 Augments Low-dose Antigen-induced Th2 Type Airway Inflammation in Mice | |||||
著者 |
Honda, Kyoko
× Honda, Kyoko× Hirata, Hirokuni× Eda, Fukiko× Fukushima, Fumiya× Yamaguchi, Bunpei× Arima, Masafumi |
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著者所属(英) | ||||||
en | ||||||
Department of Pulmonary Medical and Clinical Immunology, Dokkyo University School of Medicine | ||||||
著者所属(英) | ||||||
en | ||||||
Department of Pulmonary Medical and Clinical Immunology, Dokkyo University School of Medicine | ||||||
著者所属(英) | ||||||
en | ||||||
Department of Pulmonary Medical and Clinical Immunology, Dokkyo University School of Medicine | ||||||
著者所属(英) | ||||||
en | ||||||
Department of Pulmonary Medical and Clinical Immunology, Dokkyo University School of Medicine | ||||||
著者所属(英) | ||||||
en | ||||||
Department of Pulmonary Medical and Clinical Immunology, Dokkyo University School of Medicine | ||||||
著者所属(英) | ||||||
en | ||||||
Department of Pulmonary Medical and Clinical Immunology, Dokkyo University School of Medicine | ||||||
記事種別(英) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Original | |||||
抄録(英) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Prostaglandin D_2 (PGD_2), a mast cell-derived lipid mediator is detected in lage amounts in airways of asthmatics, but its role of largely unkown. To clarify the role of PGD_2 in Th2-type airway inflammation which characterizes asthma, we studied the effects of aerosolized PGD_2 on the inflammatory response to a low-dose antien challenge in airways of mice. Mice sensitized with ovalbumin (OVA) were challenged with a conventional-dose (1%) or a low dose (0.1%) aerosolized OVA. Mice received low - dose OVA challenge were pretreated with aerosolized PGD_2 (10^<-3>M) (PGD_2 plus low-dose OVA mice) or saline (low-dose OVA alone mice) 24 hrs before the OVA challenge. Some mice were pretreated with PGD_2 but challenged with saline (PGD_2 alone mice). Airway inflammation was evaluated by the numbers of eosinophils, lymphocytes and macrophages in bronchoalveolar lavage fluid. The degree of airway inflammation in the PGD_2 alone mice and the low-dose OVA alone mice were only marginal. However, the PGD_2 plus low-dose OVA mice displayed a similar degree of airway inflammation with mice received conventional-dose OVA challenge. Levels of interleukin (IL)-4 and IL-5 were significantly increased in the PGD_2 plus low-dose OVA mice than the low-dose OVA alone mice. PGD_2 (10^<-9>-10^<-5> M) did not affect the Th2-type cytokine production by OVA specific T cells in response to OVA stimulation in vitro. Immunohistochemical analysis of lung tissue revealed that airway epithelium of the PGD_2 plus low-dose OVA alone mice were strongly stained with monoclonal antibody against macrophage-derived chemokine (MDC), a Th2 cell-specific chemokine. These results suggest that PGD_2 augments Th2 cell -type airway inflammation via epithelial experssion of MDC. | |||||
書誌情報 |
Dokkyo journal of medical sciences 巻 30, 号 2, p. 141-151, 発行日 2003-07-25 |
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ISSN | ||||||
収録物識別子 | 03855023 |