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  1. Dokkyo Journal of Medical Sciences
  2. 44(1) 2017

Characterization of Urate Transport System in JAR and JEG-3 Cells, Human Trophoblast-derived Cell Lines

https://dmu.repo.nii.ac.jp/records/1475
https://dmu.repo.nii.ac.jp/records/1475
96755554-125b-4e72-b3b3-c733fc540677
名前 / ファイル ライセンス アクション
DJMS-44-1-6.pdf DJMS-44-1-Kiuchi-本文 (206.2 kB)
Item type 学術雑誌論文 / Journal Article(1)
タイトル
タイトル Characterization of Urate Transport System in JAR and JEG-3 Cells, Human Trophoblast-derived Cell Lines
言語
言語 eng
キーワード
主題Scheme Other
主題 urate
キーワード
主題Scheme Other
主題 placenta
キーワード
主題Scheme Other
主題 preeclampsia
キーワード
主題Scheme Other
主題 hyperuricemia
キーワード
主題Scheme Other
主題 transporters
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
著者 Kiuchi, Kaori

× Kiuchi, Kaori

en Kiuchi, Kaori

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Morita, Asuka

× Morita, Asuka

en Morita, Asuka

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Ouchi, Motoshi

× Ouchi, Motoshi

en Ouchi, Motoshi

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Otani, Naoyuki

× Otani, Naoyuki

en Otani, Naoyuki

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Jutabha, Promsuk

× Jutabha, Promsuk

en Jutabha, Promsuk

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Nohara, Masakatsu

× Nohara, Masakatsu

en Nohara, Masakatsu

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Fukasawa, Ichio

× Fukasawa, Ichio

en Fukasawa, Ichio

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Fujita, Tomoe

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Anzai, Naohiko

× Anzai, Naohiko

en Anzai, Naohiko

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著者所属
値 Department of Pharmacology and Toxicology and Department of Obstetrics and Gynecology, Dokkyo Medical University School of Medicine
著者所属
値 Department of Pharmacology and Toxicology, Dokkyo Medical University School of Medicine
著者所属
値 Department of Pharmacology and Toxicology, Dokkyo Medical University School of Medicine
著者所属
値 Department of Pharmacology and Toxicology, Dokkyo Medical University School of Medicine
著者所属
値 Department of Pharmacology and Toxicology, Dokkyo Medical University School of Medicine
著者所属
値 Department of Pharmacology and Toxicology, Dokkyo Medical University School of Medicine
著者所属
値 Department of Obstetrics and Gynecology, Dokkyo Medical University School of Medicine
著者所属
値 Department of Pharmacology and Toxicology, Dokkyo Medical University School of Medicine
著者所属
値 Department of Pharmacology and Toxicology, Dokkyo Medical University School of Medicine:Department of Pharmacology, Chiba University Graduate School of Medicine
書誌情報 Dokkyo Journal of Medical Sciences

巻 44, 号 1, p. 31-38, 発行日 2017-03-25
要旨
内容記述タイプ Other
内容記述 Urate (uric acid) is the major inert end product of purine metabolism in humans. Since it is water soluble, it requires a membranous protein called transporter for its permeation across the plasma membrane. Increased blood urate level is often seen in preeclampsia, but its precise mechanism remains unknown. Syncytiotrophoblasts function as a barrier between maternal blood and fetal one so called “blood-placental barrier”. So far, the expression of several urate transporters was identified in these cells, but it is still unclear about their contribution to urate handling in blood-placental barrier. In this study, we investigated the expression of urate transporters and the properties of [14C]urate transport in both JAR and JEG-3, human choriocarcinoma cells as a model of human placenta. Conventional PCR analysis revealed that both JAR and JEG-3 cells express strongly breast cancer resistance protein (BCRP/ABCG2) mRNA. Uptake of [14C]urate by these cells is time-dependent with Na+- and Cl--independent and voltage-insensitive manner and is not inhibited by benzbromarone, a representative renal urate transport inhibitor. Then, we focused on BCRP which shows strong mRNA expression and found that these cells have urate efflux property that is sensitive to fumitremorgin C (FMC), a BCRP inhibitor. These results suggest that BCRP is one of the important components for urate handling in human placenta in pathophysiological condition such as preeclampsia.
記事種別
値 Original
出版者
出版者 獨協医学会
ISSN
収録物識別子タイプ ISSN
収録物識別子 03855023
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00629581
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