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  1. Dokkyo Journal of Medical Sciences
  2. 30(3) 2003

Combination Therapy Consisting of Low-dose Cyclosporin A, Low-dose Prednisolone and Enalapril in Children with Steroid-Sensitive Nephrotic Syndrome

https://dmu.repo.nii.ac.jp/records/195
https://dmu.repo.nii.ac.jp/records/195
3dfa66b1-ed4b-4e2c-ae43-13f66f73ae55
名前 / ファイル ライセンス アクション
KJ00004091288.pdf KJ00004091288.pdf (543.1 kB)
Item type [ELS]学術雑誌論文 / Journal Article(1)
公開日 2017-05-24
タイトル
タイトル Combination Therapy Consisting of Low-dose Cyclosporin A, Low-dose Prednisolone and Enalapril in Children with Steroid-Sensitive Nephrotic Syndrome
言語 en
言語
言語 eng
キーワード
言語 en
主題 cyclosporin A
キーワード
言語 en
主題 enalapril
キーワード
言語 en
主題 steroid-dependent nephrotic syndrome
キーワード
言語 en
主題 children
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
雑誌書誌ID
収録物識別子 AA00629581
論文名よみ
タイトル Combination Therapy Consisting of Low-dose Cyclosporin A, Low-dose Prednisolone and Enalapril in Children with Steroid-Sensitive Nephrotic Syndrome
著者 Fukuda, Masamichi

× Fukuda, Masamichi

en Fukuda, Masamichi

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著者所属(英)
en
Department of Pediatrics, Dokkyo University School of Medicine Koshigaya Hospital
記事種別(日)
内容記述タイプ Other
内容記述 原著
記事種別(英)
内容記述タイプ Other
内容記述 Original
抄録(英)
内容記述タイプ Other
内容記述 To evaluate the extent to which combined low-dose cyclosporin A (CsA), low - dose glucocorticoid and enalapril would permit decreasing 1) steroidal toxicity, 2) the frequency of relapse of nephrotic syndrome and 3) adverse effects due to CsA, in children with steroid - dependent nephrotic syndrome. Eight children with steroid-dependent nephrotic syndrome underwent CsA therapy (mean : 2.7 mg/kg/day) for more than 24 months. Renal biopsy was performed at 24 months of CsA treatment. Height development was assessed by comparing with normal level. The changes in prednisolone dosage, as well as in the frequency of relapse, were studied. Prednisolone dosage significantly (p < 0.05) decreased to 0.20 ± 0.14 mg/kg/day after start of CsA therapy, being 0.64 ± 0.35 mg/kg/day before it. The frequency of relapse significantly (p < 0.05) decreased to 0.13 ± 0.12 times per month after start of CsA therapy, its initial frequency being 0.48 ±0.11 times per month. There were no severe histological abnormalities. The height development delay was progressed in only one patient. There were no adverse effects of CsA. It may be safely said that low-dose CsA (2.5~3.0 mg/kg) was effective in pediatric steroid-dependent nephrotic syndrome and that the trough levels of CsA of 100 to 150 ng/ml were not necessary when combined with low - dose prednisolone which would not induce major side effects.
書誌情報 Dokkyo journal of medical sciences

巻 30, 号 3, p. 229-235, 発行日 2003-10-25
ISSN
収録物識別子タイプ ISSN
収録物識別子 03855023
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