| Item type |
学術雑誌論文 / Journal Article(1) |
| タイトル |
|
|
タイトル |
Association of Skin Autofluorescence with Serum Lipids, Insulin Secretion Ability and Diabetic Complications in Patients with Poorly Controlled Type 2 Diabetes |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
SAF |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
type 2 diabetes |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
LDL-C |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
U-CPR |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Takebayashi, Kohzo
Tsuchiya, Takafumi
Shinozaki, Hiroyuki
Yamauchi, Mototaka
Suzuki, Tatsuhiko
Hara, Kenji
Inukai, Toshihiko
Hashimoto, Koshi
|
| 書誌情報 |
Dokkyo Medical Journal
巻 2,
号 1,
p. 31-42,
発行日 2023-03-25
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| 記事種別 |
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|
値 |
Original |
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Aims: The current study was performed to evaluate the association between the accumulation of advanced glycation end-products (AGEs) in skin and diabetes-related metabolic markers, atherosclerosis and diabetic complications in patients with poorly-controlled type 2 diabetes.
Methods: The skin AGE levels were assessed non-invasively by measuring skin autofluorescence (SAF). The modified low-density lipoprotein (LDL) was assessed by measuring lectin-like oxidized LDL receptor-1 ligand-containing apolipoprotein B (LAB).
Results: SAF was significantly higher in patients with type 2 diabetes than in the healthy control subjects. In patients with type 2 diabetes, SAF correlated positively with age and duration of diabetes. Furthermore, SAF exhibited significant negative correlations with LDL-cholesterol (C), triglyceride (TG) and body mass index. SAF was also negatively correlated with urinary C peptide immunoreactivity (U-CPR). In addition, SAF also exhibited significant positive correlations with cardio-ankle vascular index (CAVI) and intimal medial complex thickness of the carotid artery (IMT). Furthermore, there were significant correlations between SAF and estimated glomerular filtration rate (eGFR) (negative), urinary albumin excretion (positive).
Conclusion: SAF may be negatively associated with serum lipids such as LDL-C and TG, insulin sensitivity ability and renal dysfunction evaluated by eGFR, and positively associated with aging, duration of diabetes, markers of atherosclerosis (CAVI and IMT) in patients with poorly-controlled type 2 diabetes. |
|
言語 |
en |
| 出版者 |
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|
出版者 |
Dokkyo Medical Society |
| ISSN |
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|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
2436-522X |
| DOI |
|
|
関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.51040/dkmj.2022-041 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
DKMJ-2-1-5.pdf (175 KB)
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