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Adipose-derived Mesenchymal Stem Cells Improve Both Spontaneous Pain and Allodynia in a Rat Neuropathic Pain Model
https://dmu.repo.nii.ac.jp/records/2102
https://dmu.repo.nii.ac.jp/records/21027ec5cc26-cf0d-44a7-b50d-6d2ab84424c4
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
DJMS-45-3-Imanishi-本文 (98.8 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||
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| タイトル | ||||||||||||||||
| タイトル | Adipose-derived Mesenchymal Stem Cells Improve Both Spontaneous Pain and Allodynia in a Rat Neuropathic Pain Model | |||||||||||||||
| 言語 | ||||||||||||||||
| 言語 | eng | |||||||||||||||
| キーワード | ||||||||||||||||
| 主題Scheme | Other | |||||||||||||||
| 主題 | adipose-derived mesenchymal stem cells | |||||||||||||||
| キーワード | ||||||||||||||||
| 主題Scheme | Other | |||||||||||||||
| 主題 | neuropathic pain | |||||||||||||||
| キーワード | ||||||||||||||||
| 主題Scheme | Other | |||||||||||||||
| 主題 | allodynia | |||||||||||||||
| キーワード | ||||||||||||||||
| 主題Scheme | Other | |||||||||||||||
| 主題 | spontaneous pain | |||||||||||||||
| キーワード | ||||||||||||||||
| 主題Scheme | Other | |||||||||||||||
| 主題 | chronic constriction injury model | |||||||||||||||
| 資源タイプ | ||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||
| 資源タイプ | journal article | |||||||||||||||
| 著者 |
Imanishi, Masaya
× Imanishi, Masaya
× Asato, Hirotaka
× Umekawa, Kohei
× Sasaki, Shoichi
× Terashima, Tetsuji
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| 著者所属 | ||||||||||||||||
| Department of Plastic and Reconstructive Surgery, Dokkyo Medical University, Shimotsuga, Tochigi, Japan | ||||||||||||||||
| 著者所属 | ||||||||||||||||
| Department of Plastic and Reconstructive Surgery, Dokkyo Medical University, Shimotsuga, Tochigi, Japan | ||||||||||||||||
| 著者所属 | ||||||||||||||||
| Department of Plastic and Reconstructive Surgery, Dokkyo Medical University, Shimotsuga, Tochigi, Japan | ||||||||||||||||
| 著者所属 | ||||||||||||||||
| Department of Plastic and Reconstructive Surgery, Dokkyo Medical University, Shimotsuga, Tochigi, Japan | ||||||||||||||||
| 著者所属 | ||||||||||||||||
| Department of Anesthesiology, Dokkyo Medical University, Shimotsuga, Tochigi, Japan | ||||||||||||||||
| 書誌情報 |
Dokkyo Journal of Medical Sciences en : Dokkyo Journal of Medical Sciences 巻 45, 号 3, p. 119-125, 発行日 2018-10-25 |
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| 要旨 | ||||||||||||||||
| 内容記述タイプ | Other | |||||||||||||||
| 内容記述 | Purpose：Several studies investigated the efficacy of transplanting adipose-derived mesenchymal stem cells（ADMSCs）in the treatment of neuropathic pain in animals. However, these studies evaluated the effects of ADMSCs transplantation by assessing the mechanical allodynia but not spontaneous pain. Here, we verify whether ADMSCs transplantation improves spontaneous pain in a rat model of neuropathic pain. Methods：ADMSCs were isolated from rat adipose tissue and cultured. Chronic constriction injury（CCI） model rats were created by surgical maneuver. A total of 20 F344 rats underwent surgery and were divided into 2 groups, the ADMSCs group and the control group. One week after CCI surgery, ADMSCs were transplanted into the epineurium of the damaged nerve. The effects of ADMSCs transplantation were evaluated by the number of spontaneous pain-related behaviors and the degree of mechanical allodynia. The degree of mechanical allodynia was assessed with the von-Frey filament test. Results：No rats died during the experiments and all CCI model rats were established successfully. ADMSCs transplantation improved mechanical allodynia on and after 7-day post-transplantation and spontaneous pain on and after 21-day post-transplantation with the statistically significant differences. These improvement effects were observed until 6-week post-transplantation in mechanical allodynia and 5-week post-transplantation in spontaneous pain. Conclusion：ADMSCs transplantation improved not only mechanical allodynia but also spontaneous pain. ADMSCs transplantation may be an effective treatment for neuropathic pain in clinical practice. |
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| 記事種別 | ||||||||||||||||
| Original | ||||||||||||||||
| 出版者 | ||||||||||||||||
| 出版者 | 獨協医学会 | |||||||||||||||
| ISSN | ||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||
| 収録物識別子 | 03855023 | |||||||||||||||
| 書誌レコードID | ||||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||||
| 収録物識別子 | AA00629581 | |||||||||||||||
