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Heparin Administration Expands Flap Survival Area Possibly by Increasing the Concentration of Hepatocyte Growth Factor
https://dmu.repo.nii.ac.jp/records/2504
https://dmu.repo.nii.ac.jp/records/25042a85a5b6-5d4d-4788-8a66-dcb6da130230
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
DJMS-48-1-Kan-本文 (305.5 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| タイトル | ||||||
| タイトル | Heparin Administration Expands Flap Survival Area Possibly by Increasing the Concentration of Hepatocyte Growth Factor | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Flap survival area | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | hepatocyte growth factor | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | angiogenesis | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | heparin administration | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Kan, Takeshi
× Kan, Takeshi× Asato, Hirotaka× Fukuda, Norio× Takada, Goro× Sasaki, Shoichi |
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| 著者所属(英) | ||||||
| 言語 | en | |||||
| 値 | Department of Plastic and Reconstructive Surgery, Dokkyo Medical University School of Medicine, Tochigi 321-0293, Japan | |||||
| 著者所属(英) | ||||||
| 言語 | en | |||||
| 値 | Department of Plastic and Reconstructive Surgery, Dokkyo Medical University School of Medicine, Tochigi 321-0293, Japan | |||||
| 著者所属(英) | ||||||
| 言語 | en | |||||
| 値 | Department of Dentistry, Oral and Maxillofacial, Plastic and Reconstructive Surgery, Yamagata University School of Medicine, Yamagata 990-9585 Japan | |||||
| 著者所属(英) | ||||||
| 言語 | en | |||||
| 値 | Department of Plastic and Reconstructive Surgery, Dokkyo Medical University School of Medicine, Tochigi 321-0293, Japan | |||||
| 著者所属(英) | ||||||
| 言語 | en | |||||
| 値 | Department of Plastic and Reconstructive Surgery, Dokkyo Medical University School of Medicine, Tochigi 321-0293, Japan | |||||
| 書誌情報 |
Dokkyo Journal of Medical Sciences 巻 48, 号 1, p. 43-49, 発行日 2021-03-25 |
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| 要旨(英) | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Hepatocyte growth factor（HGF）has a strong angiogenic effect on various organs. Rapid administration of intravenous heparin increases human plasma HGF concentration. Angiogenesis has a positive effect on flap survival, and the angiogenic effect of administered heparin is expected to expand the flap survival area. Previous reports stated that heparin administration could expand the flap survival area, but they did not focus on the angiogenesis effect of heparin but instead its anti-coagulation and anti-inflammatory effects. Therefore, we studied the effects of heparin administration on flap survival in an animal model and expected its angiogenic effect to expand the flap survival area. Twenty male Wistar rats（8-9 weeks old）were randomly divided into two groups of ten：heparin and control groups. Distally based McFarlane flaps were raised in all rats. In the heparin group, 300 U/kg of heparin was administered daily, whereas, in the control group, saline was administered daily. We compared the flap survival area and the number of new blood vessels on postoperative day 7. The mean flap survival areas were significantly higher in the heparin group（57.9±5.3％）than in the control group（47.3±5.9％）（P＜0.01）. The number of CD31-positive cells in ten high power field images was significantly higher in the heparin group（60.3±7.3 cells）than in the control（43.7±4.8 cells）（P＜0.01）. In our murine model, heparin administration positively affected flap survival and angiogenesis. We consider that the increased serum HGF concentration via heparin administration is responsible for this result. | |||||
| 記事種別 | ||||||
| 値 | Original | |||||
| 出版者 | ||||||
| 出版者 | 獨協医学会 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 03855023 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00629581 | |||||
