| Item type |
[ELS]学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-05-24 |
| タイトル |
|
|
タイトル |
Effect of Poly (ADP-ribose) Polymerase Inhibitors on Hypoadiponectinemia Caused by Chronic Blockade of Nitric Oxide Synthesis in Rats |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題 |
adiponectin |
| キーワード |
|
|
言語 |
en |
|
主題 |
poly (ADP-ribose) polymerase |
| キーワード |
|
|
言語 |
en |
|
主題 |
oxidative stress |
| キーワード |
|
|
言語 |
en |
|
主題 |
adipocytokine |
| 資源タイプ |
|
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 雑誌書誌ID |
|
|
収録物識別子 |
AA00629581 |
| 論文名よみ |
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|
タイトル |
Effect of Poly (ADP-ribose) Polymerase Inhibitors on Hypoadiponectinemia Caused by Chronic Blockade of Nitric Oxide Synthesis in Rats |
| 著者 |
Wang, Xi
Satoh, Hiroko
Kase, Hiroyuki
Suzuki, Kunihiro
Iwata, Chigusa
Hattori, Yoshiyuki
Kasai, Kikuo
|
| 著者所属(英) |
|
|
|
en |
|
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Department of Endocrinology & Metabolism, Dokkyo University School of Medicine |
| 著者所属(英) |
|
|
|
en |
|
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Department of Endocrinology & Metabolism, Dokkyo University School of Medicine |
| 著者所属(英) |
|
|
|
en |
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Department of Endocrinology & Metabolism, Dokkyo University School of Medicine |
| 著者所属(英) |
|
|
|
en |
|
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Department of Endocrinology & Metabolism, Dokkyo University School of Medicine |
| 著者所属(英) |
|
|
|
en |
|
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Department of Endocrinology & Metabolism, Dokkyo University School of Medicine |
| 著者所属(英) |
|
|
|
en |
|
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Department of Endocrinology & Metabolism, Dokkyo University School of Medicine |
| 著者所属(英) |
|
|
|
en |
|
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Department of Endocrinology & Metabolism, Dokkyo University School of Medicine |
| 記事種別(日) |
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|
内容記述タイプ |
Other |
|
内容記述 |
原著 |
| 記事種別(英) |
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|
内容記述タイプ |
Other |
|
内容記述 |
Original |
| 抄録(英) |
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|
内容記述タイプ |
Other |
|
内容記述 |
Oxidant stress-induced activation of poly (ADP-ribose) polymerase (PARP) contributes to the pathogenesis of various cardiovascular diseases. Adiponectin is an adipocyte-derived anti-atherogenic protein. In the present study, we investigated the role of PARP in the development of hypoadiponectinemia caused by chronic blockade of nitric oxide synthesis with N^ω-nitro-L-arginine methyl ester (L-NAME) in rats. Decreased production of NO and increased production of O_2^- were observed in aortas from L-NAME-treated rats. Plasma adiponectin levels and adiponectin mRNA levels within adipose tissue were markedly decreased in L-NAME-treated rats. Concurrent administration of potent PARP inhibitors, INO-1001 or PJ34, with L-NAME did not restore plasma adiponectin levels or fat adiponectin mRNA levels. Thus, the cardiovascular protective effects of PARP inhibitors are not associated with adiponectin levels. Therefore, drugs which increase adiponectin levels may be beneficial alongside PARP inhibitors in the treatment of cardiovascular disease. |
| 書誌情報 |
Dokkyo journal of medical sciences
巻 32,
号 2,
p. 85-89,
発行日 2005-07-25
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| ISSN |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
03855023 |
KJ00004439018.pdf (498.0 kB)
