| Item type |
[ELS]学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-05-24 |
| タイトル |
|
|
タイトル |
Antigen Challenge-induced Expression of Amphiregulin by Mast Cells Increases Goblet-Cell Hyperplasia in a Mouse Model of Asthma |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題 |
bronchial asthma |
| キーワード |
|
|
言語 |
en |
|
主題 |
mast cell |
| キーワード |
|
|
言語 |
en |
|
主題 |
amphiregulin |
| キーワード |
|
|
言語 |
en |
|
主題 |
goblet cell |
| キーワード |
|
|
言語 |
en |
|
主題 |
airway remodeling |
| キーワード |
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|
言語 |
en |
|
主題 |
Abbreviations used |
| キーワード |
|
|
言語 |
en |
|
主題 |
EGF: epidermal growth factor |
| キーワード |
|
|
言語 |
en |
|
主題 |
MUC: mucin |
| キーワード |
|
|
言語 |
en |
|
主題 |
OVA: ovalbumin |
| キーワード |
|
|
言語 |
en |
|
主題 |
Th2: Type 2 helper T |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 雑誌書誌ID |
|
|
収録物識別子 |
AA00629581 |
| 論文名よみ |
|
|
タイトル |
Antigen Challenge-induced Expression of Amphiregulin by Mast Cells Increases Goblet-Cell Hyperplasia in a Mouse Model of Asthma |
| 著者 |
Masuda, Hiroyuki
Manaka, Takako
Toda, Masao
Sugiyama, Kumiya
Sagara, Hironori
|
| 著者所属(英) |
|
|
|
en |
|
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Department of Pulmonary Medicine and Clinical Immunology, Dokkyo University School of Medicine |
| 著者所属(英) |
|
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|
en |
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Department of Pulmonary Medicine and Clinical Immunology, Dokkyo University School of Medicine |
| 著者所属(英) |
|
|
|
en |
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Department of Pulmonary Medicine and Clinical Immunology, Dokkyo University School of Medicine |
| 著者所属(英) |
|
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|
en |
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Department of Pulmonary Medicine and Clinical Immunology, Dokkyo University School of Medicine |
| 著者所属(英) |
|
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|
en |
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Department of Pulmonary Medicine and Clinical Immunology, Dokkyo University School of Medicine |
| 記事種別(日) |
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内容記述タイプ |
Other |
|
内容記述 |
原著 |
| 記事種別(英) |
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|
内容記述タイプ |
Other |
|
内容記述 |
Original |
| 抄録(英) |
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|
内容記述タイプ |
Other |
|
内容記述 |
Mast cells play important roles in both acute-and late-phase allergic reactions mediated by IgE, such as those in bronchial asthma. Remodeling of the airway wall may contribute to the development of chronic refractory asthma; effective treatment for remodeling is currently lacking. Tryptase released by degranulated mast cells may participate in airway remodeling by stimulating the proliferation of airway smooth-muscle cells and fibroblasts and promoting the production of extracellular matrix. We found that continued antigen challenge produced time-dependent increases in the number of goblet cells, which are essential for sputum production, as well as the number of mast cells. Furthermore, the expression of amphiregulin released from mast cells was up-regulated by after ovalbumin challenges in mice. The number of amphiregulin-positive cells positively correlated with the degree of goblet-cell hyperplasia. Our results suggest that mast cells also play a key role in airway remodeling. |
| 書誌情報 |
Dokkyo journal of medical sciences
巻 33,
号 1,
p. 43-53,
発行日 2006-03-25
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
03855023 |
KJ00004451271.pdf (1.2 MB)
