{"_buckets": {"deposit": "5e77bae5-8a0a-4742-98dc-4c4f4a253bdb"}, "_deposit": {"created_by": 3, "id": "428", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "428"}, "status": "published"}, "_oai": {"id": "oai:dmu.repo.nii.ac.jp:00000428", "sets": ["37"]}, "author_link": ["1738", "1737", "1739", "1727", "1740", "1728", "1736", "1733", "1741", "1742", "1734", "1731", "1735", "1732", "1730", "1729"], "item_2_biblio_info_12": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2006-03-25", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "104", "bibliographicPageStart": "95", "bibliographicVolumeNumber": "33", "bibliographic_titles": [{"bibliographic_title": "Dokkyo journal of medical sciences"}]}]}, "item_2_description_10": {"attribute_name": "抄録(日)", "attribute_value_mlt": [{"subitem_description": "気管支喘息は気道への好酸球を中心とする慢性アレルギー性炎症性疾患として認識され,その患者は各種IgE抗体を発現し,対応するアレルゲン暴露により気道にIgEを介するアレルギー性炎症が惹起される.一方,CD40LigandはTリンパ球,肥満細胞などに発現し,CD40との伝達を介してBリンパ球のIgE産生細胞への分化,増殖に働いており,IgE産生において重要な働きをしている.しかし好酸球におけるCD40Ligand発現とIgE産生へ役割は明確ではない.我々は気管支喘息患者末梢血好酸球のCD40Ligand発現とそれがBリンパ球IgE産生誘導に与える影響について検討した.(方法)気管支喘息患者末梢血より好酸球を分離精製し,各種サイトカインで刺激しCD40L発現を検討した.また精製Bリンパ球と混合培養し上清中のIgEを測定した,(結果)気管支喘息患者群の末梢血好酸球は健常者群に比較し優位にCD40Ligandを発現し,またBリンパ球は好酸球との混合培養によりIL-4,IL-13存在下にIgEを産生した.(考案)気管支喘息患者好酸球はTリンパ球とは別個に独立してBリンパ球のIgE産生に関与する可能性が示唆された.", "subitem_description_type": "Other"}]}, "item_2_description_11": {"attribute_name": "抄録(英)", "attribute_value_mlt": [{"subitem_description": "Bronchial asthma is a chronic inflammatory disease of the airway.The accumulation of eosinophils in the airway is one of characteristic seen in patients with bronchial asthma. Asthmatic patients have a large number of IgE antibodies to environmental allergens. The exposure of these allergens induces IgE mediated allergic inflammation in the airway. Allergic reaction is a most important aspect of airway inflammation of the bronchial asthma. It is well known that CD40/CD40-Ligand interaction is a key factor for IgE production. CD40-Ligand, a surface molecule which can be expressed by T cells, mast cells and basophils has been shown to be involved in the control of B cell proliferation. We have observed following in vitro study. It have been shown that freshly isolated eosinophils from asthmatic subjects can be induced to express CD40-Ligand but not from normal controls. IgE synthesis can be induced by the interaction of B cells with eosinophils in the presence of exogenous IL-13. These result suggest that eosinophils can induce the production of IgE, independently of T cells.", "subitem_description_type": "Other"}]}, "item_2_description_15": {"attribute_name": "表示順", "attribute_value_mlt": [{"subitem_description": "14", "subitem_description_type": "Other"}]}, "item_2_description_16": {"attribute_name": "アクセション番号", "attribute_value_mlt": [{"subitem_description": "KJ00004451277", "subitem_description_type": "Other"}]}, "item_2_description_8": {"attribute_name": "記事種別(日)", "attribute_value_mlt": [{"subitem_description": "原著", "subitem_description_type": "Other"}]}, "item_2_description_9": {"attribute_name": "記事種別(英)", "attribute_value_mlt": [{"subitem_description": "Original", "subitem_description_type": "Other"}]}, "item_2_source_id_1": {"attribute_name": "雑誌書誌ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00629581", "subitem_source_identifier_type": "NCID"}]}, "item_2_source_id_19": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "03855023", "subitem_source_identifier_type": "ISSN"}]}, "item_2_text_6": {"attribute_name": "著者所属(日)", "attribute_value_mlt": [{"subitem_text_value": "獨協医科大学 内科学(呼吸器・アレルギー)"}, {"subitem_text_value": "獨協医科大学 内科学(呼吸器・アレルギー)"}, {"subitem_text_value": "獨協医科大学 内科学(呼吸器・アレルギー)"}, {"subitem_text_value": "獨協医科大学 内科学(呼吸器・アレルギー)"}, {"subitem_text_value": "獨協医科大学 内科学(呼吸器・アレルギー)"}, {"subitem_text_value": "獨協医科大学 内科学(呼吸器・アレルギー):上武呼吸器科内科病院"}, {"subitem_text_value": "獨協医科大学 内科学(呼吸器・アレルギー):上武呼吸器科内科病院"}, {"subitem_text_value": "獨協医科大学 内科学(呼吸器・アレルギー)"}]}, "item_2_text_7": {"attribute_name": "著者所属(英)", "attribute_value_mlt": [{"subitem_text_language": "en", "subitem_text_value": "Department of Pulmonary medicine and Clinical Immunology, Dokkyo University School of Medicine"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Pulmonary medicine and Clinical Immunology, Dokkyo University School of Medicine"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Pulmonary medicine and Clinical Immunology, Dokkyo University School of Medicine"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Pulmonary medicine and Clinical Immunology, Dokkyo University School of Medicine"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Pulmonary medicine and Clinical Immunology, Dokkyo University School of Medicine"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Pulmonary medicine and Clinical Immunology, Dokkyo University School of Medicine:Jobu Hospital for Respiratory Disease"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Pulmonary medicine and Clinical Immunology, Dokkyo University School of Medicine:Jobu Hospital for Respiratory Disease"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Pulmonary medicine and Clinical Immunology, Dokkyo University School of Medicine"}]}, "item_2_title_3": {"attribute_name": "論文名よみ", "attribute_value_mlt": [{"subitem_title": "IgE サンセイ ニ アタエル コウサンキュウ ジョウ リガンド ノ ヤクワリ "}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "岡田, 壮令"}, {"creatorName": "オカダ, タケノリ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "1727", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "相良, 博典"}, {"creatorName": "サガラ, ヒロノリ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "1728", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "太田, 真弓"}, {"creatorName": "オオタ, マユミ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "1729", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "増田, 浩之"}, {"creatorName": "マスダ, ヒロユキ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "1730", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "眞塩, 一樹"}, {"creatorName": "マシオ, カズキ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "1731", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "笛木, 真"}, {"creatorName": "フエキ, マコト", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "1732", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "笛木, 直人"}, {"creatorName": "フエキ, ナオト", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "1733", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "福田, 健"}, {"creatorName": "フクダ, タケシ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "1734", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Okada, Takenori", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1735", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sagara, Hironori", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1736", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ota, Mayumi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1737", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Masuda, Hiroyuki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1738", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mashio, Kazuki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1739", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Fueki, Makoto", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1740", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Fueki, Naoto", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1741", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Fukuda, Takeshi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1742", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-05-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "KJ00004451277.pdf", "filesize": [{"value": "743.1 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 743100.0, "url": {"label": "KJ00004451277.pdf", "url": "https://dmu.repo.nii.ac.jp/record/428/files/KJ00004451277.pdf"}, "version_id": "d12cc37f-d6d1-4a47-981f-2992df68bea4"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "検索用語", "subitem_subject_scheme": "Other"}, {"subitem_subject": "ヒト好酸球", "subitem_subject_scheme": "Other"}, {"subitem_subject": "気管支喘息", "subitem_subject_scheme": "Other"}, {"subitem_subject": "CD40リガンド(CD154)", "subitem_subject_scheme": "Other"}, {"subitem_subject": "IgE", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Human eosinophil", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Bronchial asthma", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "CD40ligand (CD154)", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "IgE", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "IgE産生に与える好酸球上CD40リガンドの役割", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "IgE産生に与える好酸球上CD40リガンドの役割"}, {"subitem_title": "The Role of CD40Ligand Expression on Eosinophil for IgE Production", "subitem_title_language": "en"}]}, "item_type_id": "2", "owner": "3", "path": ["37"], "permalink_uri": "https://dmu.repo.nii.ac.jp/records/428", "pubdate": {"attribute_name": "公開日", "attribute_value": "2017-05-24"}, "publish_date": "2017-05-24", "publish_status": "0", "recid": "428", "relation": {}, "relation_version_is_last": true, "title": ["IgE産生に与える好酸球上CD40リガンドの役割"], "weko_shared_id": 3}