WEKO3
アイテム
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IgE産生に与える好酸球上CD40リガンドの役割
https://dmu.repo.nii.ac.jp/records/428
https://dmu.repo.nii.ac.jp/records/428e33bf439-ea93-4303-b97b-efeeee812593
名前 / ファイル | ライセンス | アクション |
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Item type | [ELS]学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-05-24 | |||||
タイトル | ||||||
タイトル | IgE産生に与える好酸球上CD40リガンドの役割 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | The Role of CD40Ligand Expression on Eosinophil for IgE Production | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題 | 検索用語 | |||||
キーワード | ||||||
主題 | ヒト好酸球 | |||||
キーワード | ||||||
主題 | 気管支喘息 | |||||
キーワード | ||||||
主題 | CD40リガンド(CD154) | |||||
キーワード | ||||||
主題 | IgE | |||||
キーワード | ||||||
言語 | en | |||||
主題 | Human eosinophil | |||||
キーワード | ||||||
言語 | en | |||||
主題 | Bronchial asthma | |||||
キーワード | ||||||
言語 | en | |||||
主題 | CD40ligand (CD154) | |||||
キーワード | ||||||
言語 | en | |||||
主題 | IgE | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
雑誌書誌ID | ||||||
収録物識別子 | AA00629581 | |||||
論文名よみ | ||||||
タイトル | IgE サンセイ ニ アタエル コウサンキュウ ジョウ リガンド ノ ヤクワリ | |||||
著者 |
岡田, 壮令
× 岡田, 壮令× 相良, 博典× 太田, 真弓× 増田, 浩之× 眞塩, 一樹× 笛木, 真× 笛木, 直人× 福田, 健× Okada, Takenori× Sagara, Hironori× Ota, Mayumi× Masuda, Hiroyuki× Mashio, Kazuki× Fueki, Makoto× Fueki, Naoto× Fukuda, Takeshi |
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著者所属(日) | ||||||
獨協医科大学 内科学(呼吸器・アレルギー) | ||||||
著者所属(日) | ||||||
獨協医科大学 内科学(呼吸器・アレルギー) | ||||||
著者所属(日) | ||||||
獨協医科大学 内科学(呼吸器・アレルギー) | ||||||
著者所属(日) | ||||||
獨協医科大学 内科学(呼吸器・アレルギー) | ||||||
著者所属(日) | ||||||
獨協医科大学 内科学(呼吸器・アレルギー) | ||||||
著者所属(日) | ||||||
獨協医科大学 内科学(呼吸器・アレルギー):上武呼吸器科内科病院 | ||||||
著者所属(日) | ||||||
獨協医科大学 内科学(呼吸器・アレルギー):上武呼吸器科内科病院 | ||||||
著者所属(日) | ||||||
獨協医科大学 内科学(呼吸器・アレルギー) | ||||||
著者所属(英) | ||||||
en | ||||||
Department of Pulmonary medicine and Clinical Immunology, Dokkyo University School of Medicine | ||||||
著者所属(英) | ||||||
en | ||||||
Department of Pulmonary medicine and Clinical Immunology, Dokkyo University School of Medicine | ||||||
著者所属(英) | ||||||
en | ||||||
Department of Pulmonary medicine and Clinical Immunology, Dokkyo University School of Medicine | ||||||
著者所属(英) | ||||||
en | ||||||
Department of Pulmonary medicine and Clinical Immunology, Dokkyo University School of Medicine | ||||||
著者所属(英) | ||||||
en | ||||||
Department of Pulmonary medicine and Clinical Immunology, Dokkyo University School of Medicine | ||||||
著者所属(英) | ||||||
en | ||||||
Department of Pulmonary medicine and Clinical Immunology, Dokkyo University School of Medicine:Jobu Hospital for Respiratory Disease | ||||||
著者所属(英) | ||||||
en | ||||||
Department of Pulmonary medicine and Clinical Immunology, Dokkyo University School of Medicine:Jobu Hospital for Respiratory Disease | ||||||
著者所属(英) | ||||||
en | ||||||
Department of Pulmonary medicine and Clinical Immunology, Dokkyo University School of Medicine | ||||||
記事種別(日) | ||||||
内容記述タイプ | Other | |||||
内容記述 | 原著 | |||||
記事種別(英) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Original | |||||
抄録(日) | ||||||
内容記述タイプ | Other | |||||
内容記述 | 気管支喘息は気道への好酸球を中心とする慢性アレルギー性炎症性疾患として認識され,その患者は各種IgE抗体を発現し,対応するアレルゲン暴露により気道にIgEを介するアレルギー性炎症が惹起される.一方,CD40LigandはTリンパ球,肥満細胞などに発現し,CD40との伝達を介してBリンパ球のIgE産生細胞への分化,増殖に働いており,IgE産生において重要な働きをしている.しかし好酸球におけるCD40Ligand発現とIgE産生へ役割は明確ではない.我々は気管支喘息患者末梢血好酸球のCD40Ligand発現とそれがBリンパ球IgE産生誘導に与える影響について検討した.(方法)気管支喘息患者末梢血より好酸球を分離精製し,各種サイトカインで刺激しCD40L発現を検討した.また精製Bリンパ球と混合培養し上清中のIgEを測定した,(結果)気管支喘息患者群の末梢血好酸球は健常者群に比較し優位にCD40Ligandを発現し,またBリンパ球は好酸球との混合培養によりIL-4,IL-13存在下にIgEを産生した.(考案)気管支喘息患者好酸球はTリンパ球とは別個に独立してBリンパ球のIgE産生に関与する可能性が示唆された. | |||||
抄録(英) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Bronchial asthma is a chronic inflammatory disease of the airway.The accumulation of eosinophils in the airway is one of characteristic seen in patients with bronchial asthma. Asthmatic patients have a large number of IgE antibodies to environmental allergens. The exposure of these allergens induces IgE mediated allergic inflammation in the airway. Allergic reaction is a most important aspect of airway inflammation of the bronchial asthma. It is well known that CD40/CD40-Ligand interaction is a key factor for IgE production. CD40-Ligand, a surface molecule which can be expressed by T cells, mast cells and basophils has been shown to be involved in the control of B cell proliferation. We have observed following in vitro study. It have been shown that freshly isolated eosinophils from asthmatic subjects can be induced to express CD40-Ligand but not from normal controls. IgE synthesis can be induced by the interaction of B cells with eosinophils in the presence of exogenous IL-13. These result suggest that eosinophils can induce the production of IgE, independently of T cells. | |||||
書誌情報 |
Dokkyo journal of medical sciences 巻 33, 号 1, p. 95-104, 発行日 2006-03-25 |
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ISSN | ||||||
収録物識別子 | 03855023 |