ログイン
言語:

WEKO3

  • トップ
  • ランキング
To
lat lon distance
To

Field does not validate



インデックスリンク

インデックスツリー

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

{"_buckets": {"deposit": "5e77bae5-8a0a-4742-98dc-4c4f4a253bdb"}, "_deposit": {"created_by": 3, "id": "428", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "428"}, "status": "published"}, "_oai": {"id": "oai:dmu.repo.nii.ac.jp:00000428", "sets": ["37"]}, "author_link": ["1738", "1737", "1739", "1727", "1740", "1728", "1736", "1733", "1741", "1742", "1734", "1731", "1735", "1732", "1730", "1729"], "item_2_biblio_info_12": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2006-03-25", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "104", "bibliographicPageStart": "95", "bibliographicVolumeNumber": "33", "bibliographic_titles": [{"bibliographic_title": "Dokkyo journal of medical sciences"}]}]}, "item_2_description_10": {"attribute_name": "抄録(日)", "attribute_value_mlt": [{"subitem_description": "気管支喘息は気道への好酸球を中心とする慢性アレルギー性炎症性疾患として認識され,その患者は各種IgE抗体を発現し,対応するアレルゲン暴露により気道にIgEを介するアレルギー性炎症が惹起される.一方,CD40LigandはTリンパ球,肥満細胞などに発現し,CD40との伝達を介してBリンパ球のIgE産生細胞への分化,増殖に働いており,IgE産生において重要な働きをしている.しかし好酸球におけるCD40Ligand発現とIgE産生へ役割は明確ではない.我々は気管支喘息患者末梢血好酸球のCD40Ligand発現とそれがBリンパ球IgE産生誘導に与える影響について検討した.(方法)気管支喘息患者末梢血より好酸球を分離精製し,各種サイトカインで刺激しCD40L発現を検討した.また精製Bリンパ球と混合培養し上清中のIgEを測定した,(結果)気管支喘息患者群の末梢血好酸球は健常者群に比較し優位にCD40Ligandを発現し,またBリンパ球は好酸球との混合培養によりIL-4,IL-13存在下にIgEを産生した.(考案)気管支喘息患者好酸球はTリンパ球とは別個に独立してBリンパ球のIgE産生に関与する可能性が示唆された.", "subitem_description_type": "Other"}]}, "item_2_description_11": {"attribute_name": "抄録(英)", "attribute_value_mlt": [{"subitem_description": "Bronchial asthma is a chronic inflammatory disease of the airway.The accumulation of eosinophils in the airway is one of characteristic seen in patients with bronchial asthma. Asthmatic patients have a large number of IgE antibodies to environmental allergens. The exposure of these allergens induces IgE mediated allergic inflammation in the airway. Allergic reaction is a most important aspect of airway inflammation of the bronchial asthma. It is well known that CD40/CD40-Ligand interaction is a key factor for IgE production. CD40-Ligand, a surface molecule which can be expressed by T cells, mast cells and basophils has been shown to be involved in the control of B cell proliferation. We have observed following in vitro study. It have been shown that freshly isolated eosinophils from asthmatic subjects can be induced to express CD40-Ligand but not from normal controls. IgE synthesis can be induced by the interaction of B cells with eosinophils in the presence of exogenous IL-13. These result suggest that eosinophils can induce the production of IgE, independently of T cells.", "subitem_description_type": "Other"}]}, "item_2_description_15": {"attribute_name": "表示順", "attribute_value_mlt": [{"subitem_description": "14", "subitem_description_type": "Other"}]}, "item_2_description_16": {"attribute_name": "アクセション番号", "attribute_value_mlt": [{"subitem_description": "KJ00004451277", "subitem_description_type": "Other"}]}, "item_2_description_8": {"attribute_name": "記事種別(日)", "attribute_value_mlt": [{"subitem_description": "原著", "subitem_description_type": "Other"}]}, "item_2_description_9": {"attribute_name": "記事種別(英)", "attribute_value_mlt": [{"subitem_description": "Original", "subitem_description_type": "Other"}]}, "item_2_source_id_1": {"attribute_name": "雑誌書誌ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00629581", "subitem_source_identifier_type": "NCID"}]}, "item_2_source_id_19": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "03855023", "subitem_source_identifier_type": "ISSN"}]}, "item_2_text_6": {"attribute_name": "著者所属(日)", "attribute_value_mlt": [{"subitem_text_value": "獨協医科大学 内科学(呼吸器・アレルギー)"}, {"subitem_text_value": "獨協医科大学 内科学(呼吸器・アレルギー)"}, {"subitem_text_value": "獨協医科大学 内科学(呼吸器・アレルギー)"}, {"subitem_text_value": "獨協医科大学 内科学(呼吸器・アレルギー)"}, {"subitem_text_value": "獨協医科大学 内科学(呼吸器・アレルギー)"}, {"subitem_text_value": "獨協医科大学 内科学(呼吸器・アレルギー):上武呼吸器科内科病院"}, {"subitem_text_value": "獨協医科大学 内科学(呼吸器・アレルギー):上武呼吸器科内科病院"}, {"subitem_text_value": "獨協医科大学 内科学(呼吸器・アレルギー)"}]}, "item_2_text_7": {"attribute_name": "著者所属(英)", "attribute_value_mlt": [{"subitem_text_language": "en", "subitem_text_value": "Department of Pulmonary medicine and Clinical Immunology, Dokkyo University School of Medicine"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Pulmonary medicine and Clinical Immunology, Dokkyo University School of Medicine"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Pulmonary medicine and Clinical Immunology, Dokkyo University School of Medicine"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Pulmonary medicine and Clinical Immunology, Dokkyo University School of Medicine"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Pulmonary medicine and Clinical Immunology, Dokkyo University School of Medicine"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Pulmonary medicine and Clinical Immunology, Dokkyo University School of Medicine:Jobu Hospital for Respiratory Disease"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Pulmonary medicine and Clinical Immunology, Dokkyo University School of Medicine:Jobu Hospital for Respiratory Disease"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Pulmonary medicine and Clinical Immunology, Dokkyo University School of Medicine"}]}, "item_2_title_3": {"attribute_name": "論文名よみ", "attribute_value_mlt": [{"subitem_title": "IgE サンセイ ニ アタエル コウサンキュウ ジョウ リガンド ノ ヤクワリ "}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "岡田, 壮令"}, {"creatorName": "オカダ, タケノリ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "1727", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "相良, 博典"}, {"creatorName": "サガラ, ヒロノリ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "1728", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "太田, 真弓"}, {"creatorName": "オオタ, マユミ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "1729", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "増田, 浩之"}, {"creatorName": "マスダ, ヒロユキ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "1730", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "眞塩, 一樹"}, {"creatorName": "マシオ, カズキ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "1731", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "笛木, 真"}, {"creatorName": "フエキ, マコト", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "1732", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "笛木, 直人"}, {"creatorName": "フエキ, ナオト", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "1733", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "福田, 健"}, {"creatorName": "フクダ, タケシ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "1734", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Okada, Takenori", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1735", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sagara, Hironori", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1736", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ota, Mayumi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1737", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Masuda, Hiroyuki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1738", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mashio, Kazuki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1739", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Fueki, Makoto", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1740", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Fueki, Naoto", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1741", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Fukuda, Takeshi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1742", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-05-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "KJ00004451277.pdf", "filesize": [{"value": "743.1 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 743100.0, "url": {"label": "KJ00004451277.pdf", "url": "https://dmu.repo.nii.ac.jp/record/428/files/KJ00004451277.pdf"}, "version_id": "d12cc37f-d6d1-4a47-981f-2992df68bea4"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "検索用語", "subitem_subject_scheme": "Other"}, {"subitem_subject": "ヒト好酸球", "subitem_subject_scheme": "Other"}, {"subitem_subject": "気管支喘息", "subitem_subject_scheme": "Other"}, {"subitem_subject": "CD40リガンド(CD154)", "subitem_subject_scheme": "Other"}, {"subitem_subject": "IgE", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Human eosinophil", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Bronchial asthma", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "CD40ligand (CD154)", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "IgE", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "IgE産生に与える好酸球上CD40リガンドの役割", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "IgE産生に与える好酸球上CD40リガンドの役割"}, {"subitem_title": "The Role of CD40Ligand Expression on Eosinophil for IgE Production", "subitem_title_language": "en"}]}, "item_type_id": "2", "owner": "3", "path": ["37"], "permalink_uri": "https://dmu.repo.nii.ac.jp/records/428", "pubdate": {"attribute_name": "公開日", "attribute_value": "2017-05-24"}, "publish_date": "2017-05-24", "publish_status": "0", "recid": "428", "relation": {}, "relation_version_is_last": true, "title": ["IgE産生に与える好酸球上CD40リガンドの役割"], "weko_shared_id": 3}
  1. Dokkyo Journal of Medical Sciences
  2. 33(1) 2006

IgE産生に与える好酸球上CD40リガンドの役割

https://dmu.repo.nii.ac.jp/records/428
https://dmu.repo.nii.ac.jp/records/428
e33bf439-ea93-4303-b97b-efeeee812593
名前 / ファイル ライセンス アクション
KJ00004451277.pdf KJ00004451277.pdf (743.1 kB)
Item type [ELS]学術雑誌論文 / Journal Article(1)
公開日 2017-05-24
タイトル
タイトル IgE産生に与える好酸球上CD40リガンドの役割
タイトル
言語 en
タイトル The Role of CD40Ligand Expression on Eosinophil for IgE Production
言語
言語 jpn
キーワード
主題 検索用語
キーワード
主題 ヒト好酸球
キーワード
主題 気管支喘息
キーワード
主題 CD40リガンド(CD154)
キーワード
主題 IgE
キーワード
言語 en
主題 Human eosinophil
キーワード
言語 en
主題 Bronchial asthma
キーワード
言語 en
主題 CD40ligand (CD154)
キーワード
言語 en
主題 IgE
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
雑誌書誌ID
収録物識別子 AA00629581
論文名よみ
タイトル IgE サンセイ ニ アタエル コウサンキュウ ジョウ リガンド ノ ヤクワリ
著者 岡田, 壮令

× 岡田, 壮令

WEKO 1727

岡田, 壮令

ja-Kana オカダ, タケノリ

Search repository
相良, 博典

× 相良, 博典

WEKO 1728

相良, 博典

ja-Kana サガラ, ヒロノリ

Search repository
太田, 真弓

× 太田, 真弓

WEKO 1729

太田, 真弓

ja-Kana オオタ, マユミ

Search repository
増田, 浩之

× 増田, 浩之

WEKO 1730

増田, 浩之

ja-Kana マスダ, ヒロユキ

Search repository
眞塩, 一樹

× 眞塩, 一樹

WEKO 1731

眞塩, 一樹

ja-Kana マシオ, カズキ

Search repository
笛木, 真

× 笛木, 真

WEKO 1732

笛木, 真

ja-Kana フエキ, マコト

Search repository
笛木, 直人

× 笛木, 直人

WEKO 1733

笛木, 直人

ja-Kana フエキ, ナオト

Search repository
福田, 健

× 福田, 健

WEKO 1734

福田, 健

ja-Kana フクダ, タケシ

Search repository
Okada, Takenori

× Okada, Takenori

WEKO 1735

en Okada, Takenori

Search repository
Sagara, Hironori

× Sagara, Hironori

WEKO 1736

en Sagara, Hironori

Search repository
Ota, Mayumi

× Ota, Mayumi

WEKO 1737

en Ota, Mayumi

Search repository
Masuda, Hiroyuki

× Masuda, Hiroyuki

WEKO 1738

en Masuda, Hiroyuki

Search repository
Mashio, Kazuki

× Mashio, Kazuki

WEKO 1739

en Mashio, Kazuki

Search repository
Fueki, Makoto

× Fueki, Makoto

WEKO 1740

en Fueki, Makoto

Search repository
Fueki, Naoto

× Fueki, Naoto

WEKO 1741

en Fueki, Naoto

Search repository
Fukuda, Takeshi

× Fukuda, Takeshi

WEKO 1742

en Fukuda, Takeshi

Search repository
著者所属(日)
獨協医科大学 内科学(呼吸器・アレルギー)
著者所属(日)
獨協医科大学 内科学(呼吸器・アレルギー)
著者所属(日)
獨協医科大学 内科学(呼吸器・アレルギー)
著者所属(日)
獨協医科大学 内科学(呼吸器・アレルギー)
著者所属(日)
獨協医科大学 内科学(呼吸器・アレルギー)
著者所属(日)
獨協医科大学 内科学(呼吸器・アレルギー):上武呼吸器科内科病院
著者所属(日)
獨協医科大学 内科学(呼吸器・アレルギー):上武呼吸器科内科病院
著者所属(日)
獨協医科大学 内科学(呼吸器・アレルギー)
著者所属(英)
en
Department of Pulmonary medicine and Clinical Immunology, Dokkyo University School of Medicine
著者所属(英)
en
Department of Pulmonary medicine and Clinical Immunology, Dokkyo University School of Medicine
著者所属(英)
en
Department of Pulmonary medicine and Clinical Immunology, Dokkyo University School of Medicine
著者所属(英)
en
Department of Pulmonary medicine and Clinical Immunology, Dokkyo University School of Medicine
著者所属(英)
en
Department of Pulmonary medicine and Clinical Immunology, Dokkyo University School of Medicine
著者所属(英)
en
Department of Pulmonary medicine and Clinical Immunology, Dokkyo University School of Medicine:Jobu Hospital for Respiratory Disease
著者所属(英)
en
Department of Pulmonary medicine and Clinical Immunology, Dokkyo University School of Medicine:Jobu Hospital for Respiratory Disease
著者所属(英)
en
Department of Pulmonary medicine and Clinical Immunology, Dokkyo University School of Medicine
記事種別(日)
内容記述タイプ Other
内容記述 原著
記事種別(英)
内容記述タイプ Other
内容記述 Original
抄録(日)
内容記述タイプ Other
内容記述 気管支喘息は気道への好酸球を中心とする慢性アレルギー性炎症性疾患として認識され,その患者は各種IgE抗体を発現し,対応するアレルゲン暴露により気道にIgEを介するアレルギー性炎症が惹起される.一方,CD40LigandはTリンパ球,肥満細胞などに発現し,CD40との伝達を介してBリンパ球のIgE産生細胞への分化,増殖に働いており,IgE産生において重要な働きをしている.しかし好酸球におけるCD40Ligand発現とIgE産生へ役割は明確ではない.我々は気管支喘息患者末梢血好酸球のCD40Ligand発現とそれがBリンパ球IgE産生誘導に与える影響について検討した.(方法)気管支喘息患者末梢血より好酸球を分離精製し,各種サイトカインで刺激しCD40L発現を検討した.また精製Bリンパ球と混合培養し上清中のIgEを測定した,(結果)気管支喘息患者群の末梢血好酸球は健常者群に比較し優位にCD40Ligandを発現し,またBリンパ球は好酸球との混合培養によりIL-4,IL-13存在下にIgEを産生した.(考案)気管支喘息患者好酸球はTリンパ球とは別個に独立してBリンパ球のIgE産生に関与する可能性が示唆された.
抄録(英)
内容記述タイプ Other
内容記述 Bronchial asthma is a chronic inflammatory disease of the airway.The accumulation of eosinophils in the airway is one of characteristic seen in patients with bronchial asthma. Asthmatic patients have a large number of IgE antibodies to environmental allergens. The exposure of these allergens induces IgE mediated allergic inflammation in the airway. Allergic reaction is a most important aspect of airway inflammation of the bronchial asthma. It is well known that CD40/CD40-Ligand interaction is a key factor for IgE production. CD40-Ligand, a surface molecule which can be expressed by T cells, mast cells and basophils has been shown to be involved in the control of B cell proliferation. We have observed following in vitro study. It have been shown that freshly isolated eosinophils from asthmatic subjects can be induced to express CD40-Ligand but not from normal controls. IgE synthesis can be induced by the interaction of B cells with eosinophils in the presence of exogenous IL-13. These result suggest that eosinophils can induce the production of IgE, independently of T cells.
書誌情報 Dokkyo journal of medical sciences

巻 33, 号 1, p. 95-104, 発行日 2006-03-25
ISSN
収録物識別子 03855023
戻る
0
views
See details
Views

Versions

Ver.1 2023-06-20 16:20:25.903535
Show All versions

Share

Mendeley Twitter Facebook Print Addthis

Cite as

エクスポート

OAI-PMH
  • OAI-PMH JPCOAR
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by WEKO3


Powered by WEKO3