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5-HT2B Receptors-triggered Serotonin Release from Guinea-pig Isolated Colonic Mucosa：a Role of Endogenous Peptide YY
https://dmu.repo.nii.ac.jp/records/5061
https://dmu.repo.nii.ac.jp/records/50619da0eecb-42d4-4449-a651-b183ea1c85ea
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
DJMS-48-2-Kojima-本文 (242.4 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||
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| タイトル | ||||||||||||
| タイトル | 5-HT2B Receptors-triggered Serotonin Release from Guinea-pig Isolated Colonic Mucosa：a Role of Endogenous Peptide YY | |||||||||||
| 言語 | ||||||||||||
| 言語 | eng | |||||||||||
| キーワード | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | BW723C86 | |||||||||||
| キーワード | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | guinea-pig colon | |||||||||||
| キーワード | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | 5-HT2B receptor | |||||||||||
| キーワード | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | 5-HT release | |||||||||||
| キーワード | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | neuropeptide Y1 receptor | |||||||||||
| キーワード | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | peptide YY | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
| 資源タイプ | journal article | |||||||||||
| 著者 |
Kojima, Ken
× Kojima, Ken
× Kojima, Shu-ichi
× Fujita, Tomoe
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| 著者所属 | ||||||||||||
| Department of Pharmacology and Toxicology, Dokkyo Medical University School of Medicine, Mibu, Tochigi 321-0293, Japan | ||||||||||||
| 著者所属 | ||||||||||||
| Department of Pharmacology and Toxicology, Dokkyo Medical University School of Medicine, Mibu, Tochigi 321-0293, Japan | ||||||||||||
| 著者所属 | ||||||||||||
| Department of Pharmacology and Toxicology, Dokkyo Medical University School of Medicine, Mibu, Tochigi 321-0293, Japan | ||||||||||||
| 書誌情報 |
Dokkyo Journal of Medical Sciences 巻 48, 号 2, p. 81-86, 発行日 2021-07-25 |
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| 要旨 | ||||||||||||
| 内容記述タイプ | Other | |||||||||||
| 内容記述 | Purpose：The effect of 5-HT2B receptor-selective agonist BW723C86 was investigated on the outflow of 5-hydroxytryptamine（5-HT）from isolated muscle layer-free mucosal preparations of guinea-pig colon. Methods：The mucosal preparations were incubated in vitro and the outflow of 5-HT from these preparations was determined by high-performance liquid chromatography with electrochemical detection. Results：BW723C86（1-10 μM）produced a sustained increase in the outflow of 5-HT from the mucosal preparations. The BW723C86-evoked 5-HT outflow was inhibited by the two different 5-HT2B receptor antagonists, olanzapine（100 nM）and RS127445（100 nM）. The neuropeptide Y1 receptor antagonist BIBO3304（300 nM）markedly inhibited the BW723C86-evoked 5-HT outflow. Conclusion：We found that 5-HT2B receptor-triggered 5-HT release from guinea-pig colonic mucosa is mediated by the activation of 5-HT2B receptors located at endocrine cells and that the 5-HT2B receptortriggered 5-HT release is mediated by endogenously released peptide YY, acting via Y1 receptors. Given that both 5-HT and peptide YY are well-known mediators of nausea and vomiting, the 5-HT2B receptors located at endocrine cells may play a role in the generation of nausea and vomiting. |
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| 記事種別 | ||||||||||||
| Original | ||||||||||||
| 出版者 | ||||||||||||
| 出版者 | 獨協医学会 | |||||||||||
| ISSN | ||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||
| 収録物識別子 | 03855023 | |||||||||||
| 書誌レコードID | ||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||
| 収録物識別子 | AA00629581 | |||||||||||
