| Item type |
学術雑誌論文 / Journal Article(1) |
| タイトル |
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タイトル |
Extended Pelvic Lymph Node Dissection during Robotic Prostate Surgery for Intermediate- to High-risk Prostate Cancer: A Propensity Score-matched Analysis for Biochemical Recurrence-free Survival |
| 言語 |
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言語 |
eng |
| キーワード |
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主題Scheme |
Other |
|
主題 |
biochemical recurrence-free survival |
| キーワード |
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主題Scheme |
Other |
|
主題 |
extended pelvic lymph node dissection |
| キーワード |
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主題Scheme |
Other |
|
主題 |
high-risk prostate cancer |
| キーワード |
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主題Scheme |
Other |
|
主題 |
intermediate-risk prostate cancer |
| キーワード |
|
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主題Scheme |
Other |
|
主題 |
propensity score-matched analysis |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Yashi, Masahiro
Fuchizawa, Hirotaka
Yokoyama, Megumi
Okazaki, Akihito
Nakamura, Gaku
Kokubun, Hidetoshi
Uematsu, Toshitaka
Suzuki, Issei
Sakamoto, Kazumasa
Tokura, Yuumi
Kijima, Toshiki
Kaji, Yasushi
Ishida, Kazuyuki
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| 著者所属 |
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Department of Urology, Dokkyo Medical University |
| 著者所属 |
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Department of Urology, Dokkyo Medical University |
| 著者所属 |
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Department of Urology, Dokkyo Medical University |
| 著者所属 |
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Department of Urology, Dokkyo Medical University |
| 著者所属 |
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Department of Urology, Dokkyo Medical University |
| 著者所属 |
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Department of Urology, Dokkyo Medical University |
| 著者所属 |
|
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Department of Urology, Dokkyo Medical University |
| 著者所属 |
|
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Department of Urology, Dokkyo Medical University |
| 著者所属 |
|
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Department of Urology, Dokkyo Medical University |
| 著者所属 |
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Department of Urology, Dokkyo Medical University |
| 著者所属 |
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Department of Urology, Dokkyo Medical University |
| 著者所属 |
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Department of Radiology, Dokkyo Medical University |
| 著者所属 |
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Department of Diagnostic Pathology, Dokkyo Medical University |
| 著者所属 |
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Department of Urology, Dokkyo Medical University |
| 書誌情報 |
Dokkyo Medical Journal
巻 1,
号 1,
p. 39-48,
発行日 2022-03
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Background: There are pros and cons regarding the benefit of extended pelvic lymph node dissection (PLND) during surgery for prostate cancer (PCa). A randomized controlled trial failed to demonstrate any survival benefits, and the therapeutic role of PLND remains unclear. We evaluated early survival outcome using a propensity score (PS)-matched analysis.
Methods: Three hundred ninety-nine patients with intermediate- to high-risk PCa were enrolled. They were determined to have a lymph node (LN) invasion probability of greater than 7% on the established nomogram. The National Comprehensive Cancer Network classification was used as risk stratification. Biochemical recurrence (BCR)-free survival was compared between the two groups divided by the threshold of the LN yield set at 15.
Results: The mean LN yield was 23.7 and 3.4 in the sufficient (n = 217) and insufficient (n = 182) LN yield groups, respectively. In the unmatched cohort, the advantage of the 3-year BCR-free survival for sufficient LN yield remained at 10.0% (hazard ratio [HR] 0.68, 95% confidence interval [CI] 0.43-1.07; p = 0.098). In the PS-matched cohort with 133 patients in each group, the difference in the 3-year BCR-free survival rate widened to 15.8% (HR 0.54, 95% CI 0.31-0.93; p = 0.027). A Cox regression multivariate analysis performed on the model with postoperative pathological factors showed an independent predictive value of LN yield.
Conclusions: The results demonstrate the therapeutic role of PLND in intermediate- to high-risk PCa. The benefit of PLND depends on the surgeon adhering to the template and removing a sufficient number of LNs in patients with an optimal risk-range. |
| 記事種別 |
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Original |
| 出版者 |
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出版者 |
Dokkyo Medical Society |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
2436-5211 |
| DOI |
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識別子タイプ |
DOI |
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関連識別子 |
10.51040/dkmj.1.1_39 |
DKMJ-1-1-Yashi-Fulltext (405.6 kB)
