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Extended Pelvic Lymph Node Dissection during Robotic Prostate Surgery for Intermediate- to High-risk Prostate Cancer: A Propensity Score-matched Analysis for Biochemical Recurrence-free Survival
https://dmu.repo.nii.ac.jp/records/5124
https://dmu.repo.nii.ac.jp/records/5124becfed36-ee86-4e5a-82c6-9c8c57059aed
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
DKMJ-1-1-Yashi-Fulltext (405.6 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| タイトル | ||||||
| タイトル | Extended Pelvic Lymph Node Dissection during Robotic Prostate Surgery for Intermediate- to High-risk Prostate Cancer: A Propensity Score-matched Analysis for Biochemical Recurrence-free Survival | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | biochemical recurrence-free survival | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | extended pelvic lymph node dissection | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | high-risk prostate cancer | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | intermediate-risk prostate cancer | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | propensity score-matched analysis | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Yashi, Masahiro
× Yashi, Masahiro× Fuchizawa, Hirotaka× Yokoyama, Megumi× Okazaki, Akihito× Nakamura, Gaku× Kokubun, Hidetoshi× Uematsu, Toshitaka× Suzuki, Issei× Sakamoto, Kazumasa× Tokura, Yuumi× Kijima, Toshiki× Kaji, Yasushi× Ishida, Kazuyuki |
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| 著者所属 | ||||||
| 値 | Department of Urology, Dokkyo Medical University | |||||
| 著者所属 | ||||||
| 値 | Department of Urology, Dokkyo Medical University | |||||
| 著者所属 | ||||||
| 値 | Department of Urology, Dokkyo Medical University | |||||
| 著者所属 | ||||||
| 値 | Department of Urology, Dokkyo Medical University | |||||
| 著者所属 | ||||||
| 値 | Department of Urology, Dokkyo Medical University | |||||
| 著者所属 | ||||||
| 値 | Department of Urology, Dokkyo Medical University | |||||
| 著者所属 | ||||||
| 値 | Department of Urology, Dokkyo Medical University | |||||
| 著者所属 | ||||||
| 値 | Department of Urology, Dokkyo Medical University | |||||
| 著者所属 | ||||||
| 値 | Department of Urology, Dokkyo Medical University | |||||
| 著者所属 | ||||||
| 値 | Department of Urology, Dokkyo Medical University | |||||
| 著者所属 | ||||||
| 値 | Department of Urology, Dokkyo Medical University | |||||
| 著者所属 | ||||||
| 値 | Department of Radiology, Dokkyo Medical University | |||||
| 著者所属 | ||||||
| 値 | Department of Diagnostic Pathology, Dokkyo Medical University | |||||
| 著者所属 | ||||||
| 値 | Department of Urology, Dokkyo Medical University | |||||
| 書誌情報 |
Dokkyo Medical Journal 巻 1, 号 1, p. 39-48, 発行日 2022-03 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background: There are pros and cons regarding the benefit of extended pelvic lymph node dissection (PLND) during surgery for prostate cancer (PCa). A randomized controlled trial failed to demonstrate any survival benefits, and the therapeutic role of PLND remains unclear. We evaluated early survival outcome using a propensity score (PS)-matched analysis. Methods: Three hundred ninety-nine patients with intermediate- to high-risk PCa were enrolled. They were determined to have a lymph node (LN) invasion probability of greater than 7% on the established nomogram. The National Comprehensive Cancer Network classification was used as risk stratification. Biochemical recurrence (BCR)-free survival was compared between the two groups divided by the threshold of the LN yield set at 15. Results: The mean LN yield was 23.7 and 3.4 in the sufficient (n = 217) and insufficient (n = 182) LN yield groups, respectively. In the unmatched cohort, the advantage of the 3-year BCR-free survival for sufficient LN yield remained at 10.0% (hazard ratio [HR] 0.68, 95% confidence interval [CI] 0.43-1.07; p = 0.098). In the PS-matched cohort with 133 patients in each group, the difference in the 3-year BCR-free survival rate widened to 15.8% (HR 0.54, 95% CI 0.31-0.93; p = 0.027). A Cox regression multivariate analysis performed on the model with postoperative pathological factors showed an independent predictive value of LN yield. Conclusions: The results demonstrate the therapeutic role of PLND in intermediate- to high-risk PCa. The benefit of PLND depends on the surgeon adhering to the template and removing a sufficient number of LNs in patients with an optimal risk-range. |
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| 記事種別 | ||||||
| 値 | Original | |||||
| 出版者 | ||||||
| 出版者 | Dokkyo Medical Society | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2436-5211 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.51040/dkmj.1.1_39 | |||||
