WEKO3
アイテム
Regulation of Glycerophospholipid and Cholesterol Synthesis in Cells by Hydroxylated Cholesterols (Oxysterols)
https://dmu.repo.nii.ac.jp/records/5255
https://dmu.repo.nii.ac.jp/records/5255c48c916c-4d35-447d-8113-4855dc724a5c
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
DKMJ-1-3-Ando-Fulltext (970.0 kB)
|
.png)
|
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| タイトル | ||||||
| タイトル | Regulation of Glycerophospholipid and Cholesterol Synthesis in Cells by Hydroxylated Cholesterols (Oxysterols) | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Oxysterols | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Phosphatidylethanolamine | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Cholesterol | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Pcyt2 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Hmgcr | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 25-Hydroxycholesterol | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Cytochrome P450 46A1 | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Ando, Hiromi
× Ando, Hiromi× Shinohara, Yasutake× Arai, Maki× Yamashita, Satoko× Sugimoto, Hiroyuki |
|||||
| 著者所属 | ||||||
| 値 | Department of Biochemistry, Dokkyo Medical University Tochigi Japan | |||||
| 著者所属 | ||||||
| 値 | Department of Biochemistry, Dokkyo Medical University Tochigi Japan | |||||
| 著者所属 | ||||||
| 値 | Department of Biochemistry, Dokkyo Medical University Tochigi Japan | |||||
| 著者所属 | ||||||
| 値 | Department of Biochemistry, Dokkyo Medical University Tochigi Japan | |||||
| 著者所属 | ||||||
| 値 | Department of Biochemistry, Dokkyo Medical University Tochigi Japan | |||||
| 書誌情報 |
Dokkyo Medical Journal 巻 1, 号 3, p. 157-166, 発行日 2022-09 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Phosphatidylethanolamine (PE) and cholesterol are major lipid components of mammalian cell membranes. The rate limiting enzymes for the synthesis of PE and cholesterol are CTP: phosphoethanolamine cytidylyltransferase (Pcyt2) and 3-hydroxy-3-methylglutaryl-CoA reductase (Hmgcr), respectively. The transcription and activity of these enzymes in NIH3T3 cells are suppressed by fetal bovine serum (FBS) and hydroxylated cholesterol (oxysterols) in similar dose-dependent manners. These results suggested that the intrinsic oxysterol concentration in cells is important for maintaining membrane lipid components, leading us to investigate the regulation of oxysterol-producing enzyme activity in cells. Using NIH3T3 cells, we found that of all oxysterol-producing enzymes, only the 24S-hydroxycholesterol producing enzyme cytochrome P450 46A1 (Cyp46A1) is expressed. Transcription of Cyp46A1 is suppressed by FBS, and we identified insulin-like growth factor II (IGF-II) in FBS as the factor suppressing Cyp46A1 transcription. The oxysterol level in NIH3T3 cells is also suppressed by IGF-II. These results suggested that the classical hormone IGF-II regulates the oxysterol content in cells and transduces cellular signals. | |||||
| 記事種別 | ||||||
| 値 | Review Article | |||||
| 出版者 | ||||||
| 出版者 | Dokkyo Medical Society | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2436-522X | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.51040/dkmj.2022-018 | |||||
