{"_buckets": {"deposit": "a194e55f-bd33-44aa-a688-5be0c2734bf8"}, "_deposit": {"created_by": 3, "id": "535", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "535"}, "status": "published"}, "_oai": {"id": "oai:dmu.repo.nii.ac.jp:00000535", "sets": ["41"]}, "author_link": ["2191"], "item_2_biblio_info_12": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2007-03-01", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "T29", "bibliographicPageStart": "T21", "bibliographicVolumeNumber": "34", "bibliographic_titles": [{"bibliographic_title": "Dokkyo journal of medical sciences"}]}]}, "item_2_description_10": {"attribute_name": "抄録(日)", "attribute_value_mlt": [{"subitem_description": "t(17;19)急性リンパ性白血病acute lymphoblastic leukemia (t(17;19)^+ ALL)はE2A-HLFの抗アポトーシス能により白血病化する. t(17;19)^+ ALLはsurvivinが高発現し, E2A-HLFドミナントネガティブ変異dominant negative (dn)の導入でsurvivinの発現が抑制される一方, t(17;19)を有しないALL (t(17;19)^- ALL)細胞にE2A-HLFを導入するとsurvivinが高発現した. Survivinはt(17;19)^+ ALLでは全細胞周期で高発現していた.レポーターアッセイでE2A-HLFはsurvivinプロモーターの細胞周期関連領域を制御していた. t(17;19)^+ ALL細胞にsurvivin (dn)を導入すると全細胞周期でアポトーシスが生じた.以上の結果からE2A-HLFが細胞全周期においてsurvivinを発現誘導し白血病化に関与していることが示唆された.", "subitem_description_type": "Other"}]}, "item_2_description_15": {"attribute_name": "表示順", "attribute_value_mlt": [{"subitem_description": "15", "subitem_description_type": "Other"}]}, "item_2_description_16": {"attribute_name": "アクセション番号", "attribute_value_mlt": [{"subitem_description": "KJ00005058611", "subitem_description_type": "Other"}]}, "item_2_description_8": {"attribute_name": "記事種別(日)", "attribute_value_mlt": [{"subitem_description": "学位申請論文", "subitem_description_type": "Other"}]}, "item_2_description_9": {"attribute_name": "記事種別(英)", "attribute_value_mlt": [{"subitem_description": "Doctoral Treatise", "subitem_description_type": "Other"}]}, "item_2_source_id_1": {"attribute_name": "雑誌書誌ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00629581", "subitem_source_identifier_type": "NCID"}]}, "item_2_source_id_19": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "03855023", "subitem_source_identifier_type": "ISSN"}]}, "item_2_text_6": {"attribute_name": "著者所属(日)", "attribute_value_mlt": [{"subitem_text_value": "獨協医科大学小児科学"}]}, "item_2_title_3": {"attribute_name": "論文名よみ", "attribute_value_mlt": [{"subitem_title": "Survivin ワ E2A-HLF ユウゴウ テンシャ インシ ノ カリュウ デ ハッケツビョウ カ ニ カンヨ スル"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "奥谷, 真由子"}, {"creatorName": "オクヤ, マユコ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "2191", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-05-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "KJ00005058611.pdf", "filesize": [{"value": "905.2 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 905200.0, "url": {"label": "KJ00005058611.pdf", "url": "https://dmu.repo.nii.ac.jp/record/535/files/KJ00005058611.pdf"}, "version_id": "42d5d2d4-90dc-4e77-a321-cedcc7656d4d"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "survivin", "subitem_subject_scheme": "Other"}, {"subitem_subject": "E2A-HLF", "subitem_subject_scheme": "Other"}, {"subitem_subject": "t(17;19)^+ ALL", "subitem_subject_scheme": "Other"}, {"subitem_subject": "アポトーシス", "subitem_subject_scheme": "Other"}, {"subitem_subject": "細胞周期非依存的発現", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "SurvivinはE2A-HLF融合転写因子の下流で白血病化に関与する", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "SurvivinはE2A-HLF融合転写因子の下流で白血病化に関与する"}]}, "item_type_id": "2", "owner": "3", "path": ["41"], "permalink_uri": "https://dmu.repo.nii.ac.jp/records/535", "pubdate": {"attribute_name": "公開日", "attribute_value": "2017-05-24"}, "publish_date": "2017-05-24", "publish_status": "0", "recid": "535", "relation": {}, "relation_version_is_last": true, "title": ["SurvivinはE2A-HLF融合転写因子の下流で白血病化に関与する"], "weko_shared_id": 3}