| Item type |
学術雑誌論文 / Journal Article(1) |
| タイトル |
|
|
タイトル |
Reperfusion Injury after Acute Myocardial Infarction |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
reperfusion injury |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
acute myocardial infarction |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Yamada, Kota
Mizutani, Yukiko
Nakamura, Hidehiko
Ukaji, Tomoaki
Sato, Hirotsugu
Koshikawa, Yuuri
Hori, Yuichi
Itabashi, Yuji
Nakahara, Shiro
Ishikawa, Tetsuya
Kobayashi, Sayuki
Taguchi, Isao
|
| 著者所属 |
|
|
|
Department of Cardiology, Dokkyo Medical University Saitama Medical Center |
| 著者所属 |
|
|
|
Department of Cardiology, Dokkyo Medical University Saitama Medical Center |
| 著者所属 |
|
|
|
Department of Cardiology, Dokkyo Medical University Saitama Medical Center |
| 著者所属 |
|
|
|
Department of Cardiology, Dokkyo Medical University Saitama Medical Center |
| 著者所属 |
|
|
|
Department of Cardiology, Dokkyo Medical University Saitama Medical Center |
| 著者所属 |
|
|
|
Department of Cardiology, Dokkyo Medical University Saitama Medical Center |
| 著者所属 |
|
|
|
Department of Cardiology, Dokkyo Medical University Saitama Medical Center |
| 著者所属 |
|
|
|
Department of Cardiology, Dokkyo Medical University Saitama Medical Center |
| 著者所属 |
|
|
|
Department of Cardiology, Dokkyo Medical University Saitama Medical Center |
| 著者所属 |
|
|
|
Department of Cardiology, Dokkyo Medical University Saitama Medical Center |
| 著者所属 |
|
|
|
Department of Cardiology, Dokkyo Medical University Saitama Medical Center |
| 著者所属 |
|
|
|
Department of Cardiology, Dokkyo Medical University Saitama Medical Center |
| 書誌情報 |
Dokkyo Medical Journal
巻 1,
号 4,
p. 274-284,
発行日 2022-12
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Acute myocardial infarction (AMI) is a major cause of morbidity and mortality worldwide. Primary percutaneous coronary intervention (PPCI) is the gold standard treatment for patients presenting with ST-segment elevation myocardial infarction (STEMI). PPCI reperfusion therapy has the potential to reduce infarct size, preserve the left ventricle ejection fraction (LVEF), prevent lethal complications, and improve prognosis. A significant proportion of STEMI patients, however, develop post-infarct heart failure despite optimal PPCI. One of the reasons for post-infarct heart failure is that reperfusion injury increases the infarct area after PPCI. This article reviews the current understanding and up-to-date evidence basis for therapeutic intervention of reperfusion injury. Specifically, the combination of myocardial ischemia secondary to acute coronary occlusion and reperfusion injury leads to further myocardial injury and cell death. Multiple treatment modalities have been shown to be cardioprotective and reduce reperfusion injury in experimental animal models. Recent clinical trials have assessed multiple cardioprotective strategies, including ischemic pre- and post-conditioning, pharmacologic therapies, and mechanical devices. While several therapies have been shown to reduce infarct size in animal models or proof-of-concept studies, many large-scale trial results have proven inconsistent and disappointing. To decrease the incidence of severe heart failure in patients and extend healthy life expectancy in an aging society, further development of prevention strategies for reperfusion injury is needed, including novel maneuvers, drugs, devices, and combinations of the three. |
| 記事種別 |
|
|
|
Review Article |
| 出版者 |
|
|
出版者 |
Dokkyo Medical Society |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
2436-522X |
| DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.51040/dkmj.2022-028 |
DKMJ-1-4-Yamada-Fulltext (161.9 kB)
