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  1. Dokkyo Medical Journal
  2. 1(4) 2022

Tumor Necrosis Factor Blockade Fails to Improve Small Airway Obstruction in Rheumatoid Arthritis

https://dmu.repo.nii.ac.jp/records/5357
https://dmu.repo.nii.ac.jp/records/5357
1b527e39-73d8-48e5-bc41-f431ba31009b
名前 / ファイル ライセンス アクション
DKMJ-1-4-3.pdf DKMJ-1-4-Yamazaki-Fulltext (128.8 kB)
license.icon
Item type 学術雑誌論文 / Journal Article(1)
タイトル
タイトル Tumor Necrosis Factor Blockade Fails to Improve Small Airway Obstruction in Rheumatoid Arthritis
言語
言語 eng
キーワード
主題Scheme Other
主題 rheumatoid arthritis
キーワード
主題Scheme Other
主題 TNF blockade
キーワード
主題Scheme Other
主題 small airway disease
キーワード
主題Scheme Other
主題 pulmonary function
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
著者 Yamazaki, Ryutaro

× Yamazaki, Ryutaro

WEKO 47273

en Yamazaki, Ryutaro

Search repository
Kurasawa, Kazuhiro

× Kurasawa, Kazuhiro

WEKO 3544

en Kurasawa, Kazuhiro

Search repository
Nagasawa, Junya

× Nagasawa, Junya

WEKO 47274

en Nagasawa, Junya

Search repository
Tanaka, Ayae

× Tanaka, Ayae

WEKO 4223

en Tanaka, Ayae

Search repository
Arai, Satoko

× Arai, Satoko

WEKO 3534

en Arai, Satoko

Search repository
Owada, Takayoshi

× Owada, Takayoshi

WEKO 3537

en Owada, Takayoshi

Search repository
Arima, Masafumi

× Arima, Masafumi

WEKO 438

en Arima, Masafumi

Search repository
Maezawa, Reika

× Maezawa, Reika

WEKO 3540

en Maezawa, Reika

Search repository
著者所属
Department of Rheumatology, Dokkyo Medical University School of Medicine, Tochigi, Japan
著者所属
Department of Rheumatology, Dokkyo Medical University School of Medicine, Tochigi, Japan
著者所属
Department of Rheumatology, Dokkyo Medical University School of Medicine, Tochigi, Japan
著者所属
Department of Rheumatology, Dokkyo Medical University School of Medicine, Tochigi, Japan
著者所属
Department of Rheumatology, Dokkyo Medical University School of Medicine, Tochigi, Japan
著者所属
Department of Rheumatology, Dokkyo Medical University School of Medicine, Tochigi, Japan
著者所属
Department of Rheumatology, Dokkyo Medical University School of Medicine, Tochigi, Japan
著者所属
Department of Rheumatology, Dokkyo Medical University School of Medicine, Tochigi, Japan
書誌情報 Dokkyo Medical Journal

巻 1, 号 4, p. 285-291, 発行日 2022-12
抄録
内容記述タイプ Abstract
内容記述 Objective: To determine whether tumor necrosis factor (TNF) blockade improves small airway obstruction in rheumatoid arthritis (RA) patients without apparent respiratory symptoms.

Methods: Pulmonary function tests were performed before and one year after TNF blockade therapy in 29 RA patients without apparent respiratory symptoms. As a control, pulmonary function was examined at a one-year interval in 27 RA patients with conventional disease-modifying antirheumatic drugs (DMARDs) alone. Small airway obstruction was diagnosed when one of maximal mid-expiratory flow rate (MMEF), forced expiratory flow at 50% (FEF50) or 75% (FEF75) of the vital capacity was decreased to less than 60%, 55%, or 45% of predicted values, respectively.

Results: Small airway obstruction was found in 62.5% of RA patients. No differences were found in age, sex, disease duration, or disease activities. TNF inhibitors dramatically reduced disease activities. However, TNF inhibitors failed to improve small airway obstructions but worsened them.

Conclusions: TNF blockade fails to improve small airway obstruction, suggesting that TNF-independent pathways play important roles in the development of small airway obstruction in RA.
記事種別
Original
出版者
出版者 Dokkyo Medical Society
ISSN
収録物識別子タイプ ISSN
収録物識別子 2436-522X
DOI
識別子タイプ DOI
関連識別子 10.51040/dkmj.2022-013
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