{"_buckets": {"deposit": "809fb262-0af0-4217-9327-337315e4d5a7"}, "_deposit": {"created_by": 14, "id": "5357", "owners": [14], "pid": {"revision_id": 0, "type": "depid", "value": "5357"}, "status": "published"}, "_oai": {"id": "oai:dmu.repo.nii.ac.jp:00005357", "sets": ["236"]}, "author_link": ["47273", "47274", "3544", "3534", "3537", "438", "4223", "3540"], "item_10001_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2022-12", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "4", "bibliographicPageEnd": "291", "bibliographicPageStart": "285", "bibliographicVolumeNumber": "1", "bibliographic_titles": [{"bibliographic_title": "Dokkyo Medical Journal"}]}]}, "item_10001_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Objective: To determine whether tumor necrosis factor (TNF) blockade improves small airway obstruction in rheumatoid arthritis (RA) patients without apparent respiratory symptoms.\n\nMethods: Pulmonary function tests were performed before and one year after TNF blockade therapy in 29 RA patients without apparent respiratory symptoms. As a control, pulmonary function was examined at a one-year interval in 27 RA patients with conventional disease-modifying antirheumatic drugs (DMARDs) alone. Small airway obstruction was diagnosed when one of maximal mid-expiratory flow rate (MMEF), forced expiratory flow at 50% (FEF50) or 75% (FEF75) of the vital capacity was decreased to less than 60%, 55%, or 45% of predicted values, respectively.\n\nResults: Small airway obstruction was found in 62.5% of RA patients. No differences were found in age, sex, disease duration, or disease activities. TNF inhibitors dramatically reduced disease activities. However, TNF inhibitors failed to improve small airway obstructions but worsened them.\n\nConclusions: TNF blockade fails to improve small airway obstruction, suggesting that TNF-independent pathways play important roles in the development of small airway obstruction in RA.", "subitem_description_type": "Abstract"}]}, "item_10001_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Dokkyo Medical Society"}]}, "item_10001_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.51040/dkmj.2022-013", "subitem_relation_type_select": "DOI"}}]}, "item_10001_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "2436-522X", "subitem_source_identifier_type": "ISSN"}]}, "item_10001_text_24": {"attribute_name": "著者所属", "attribute_value_mlt": [{"subitem_text_value": "Department of Rheumatology, Dokkyo Medical University School of Medicine, Tochigi, Japan"}, {"subitem_text_value": "Department of Rheumatology, Dokkyo Medical University School of Medicine, Tochigi, Japan"}, {"subitem_text_value": "Department of Rheumatology, Dokkyo Medical University School of Medicine, Tochigi, Japan"}, {"subitem_text_value": "Department of Rheumatology, Dokkyo Medical University School of Medicine, Tochigi, Japan"}, {"subitem_text_value": "Department of Rheumatology, Dokkyo Medical University School of Medicine, Tochigi, Japan"}, {"subitem_text_value": "Department of Rheumatology, Dokkyo Medical University School of Medicine, Tochigi, Japan"}, {"subitem_text_value": "Department of Rheumatology, Dokkyo Medical University School of Medicine, Tochigi, Japan"}, {"subitem_text_value": "Department of Rheumatology, Dokkyo Medical University School of Medicine, Tochigi, Japan"}]}, "item_10001_text_33": {"attribute_name": "記事種別", "attribute_value_mlt": [{"subitem_text_value": "Original"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Yamazaki, Ryutaro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "47273", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kurasawa, Kazuhiro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "3544", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nagasawa, Junya", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "47274", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tanaka, Ayae", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "4223", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Arai, Satoko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "3534", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Owada, Takayoshi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "3537", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Arima, Masafumi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "438", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Maezawa, Reika", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "3540", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2023-03-27"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "DKMJ-1-4-3.pdf", "filesize": [{"value": "128.8 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_11", "mimetype": "application/pdf", "size": 128800.00000000001, "url": {"label": "DKMJ-1-4-Yamazaki-Fulltext", "url": "https://dmu.repo.nii.ac.jp/record/5357/files/DKMJ-1-4-3.pdf"}, "version_id": "52c90ee1-b233-493c-8502-9fd1f363345a"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "rheumatoid arthritis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "TNF blockade", "subitem_subject_scheme": "Other"}, {"subitem_subject": "small airway disease", "subitem_subject_scheme": "Other"}, {"subitem_subject": "pulmonary function", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Tumor Necrosis Factor Blockade Fails to Improve Small Airway Obstruction in Rheumatoid Arthritis", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Tumor Necrosis Factor Blockade Fails to Improve Small Airway Obstruction in Rheumatoid Arthritis"}]}, "item_type_id": "10001", "owner": "14", "path": ["236"], "permalink_uri": "https://dmu.repo.nii.ac.jp/records/5357", "pubdate": {"attribute_name": "公開日", "attribute_value": "2023-03-27"}, "publish_date": "2023-03-27", "publish_status": "0", "recid": "5357", "relation": {}, "relation_version_is_last": true, "title": ["Tumor Necrosis Factor Blockade Fails to Improve Small Airway Obstruction in Rheumatoid Arthritis"], "weko_shared_id": -1}