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Tumor Necrosis Factor Blockade Fails to Improve Small Airway Obstruction in Rheumatoid Arthritis
https://dmu.repo.nii.ac.jp/records/5357
https://dmu.repo.nii.ac.jp/records/53571b527e39-73d8-48e5-bc41-f431ba31009b
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
DKMJ-1-4-Yamazaki-Fulltext (128.8 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| タイトル | ||||||
| タイトル | Tumor Necrosis Factor Blockade Fails to Improve Small Airway Obstruction in Rheumatoid Arthritis | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | rheumatoid arthritis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | TNF blockade | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | small airway disease | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | pulmonary function | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Yamazaki, Ryutaro
× Yamazaki, Ryutaro× Kurasawa, Kazuhiro× Nagasawa, Junya× Tanaka, Ayae× Arai, Satoko× Owada, Takayoshi× Arima, Masafumi× Maezawa, Reika |
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| 著者所属 | ||||||
| 値 | Department of Rheumatology, Dokkyo Medical University School of Medicine, Tochigi, Japan | |||||
| 著者所属 | ||||||
| 値 | Department of Rheumatology, Dokkyo Medical University School of Medicine, Tochigi, Japan | |||||
| 著者所属 | ||||||
| 値 | Department of Rheumatology, Dokkyo Medical University School of Medicine, Tochigi, Japan | |||||
| 著者所属 | ||||||
| 値 | Department of Rheumatology, Dokkyo Medical University School of Medicine, Tochigi, Japan | |||||
| 著者所属 | ||||||
| 値 | Department of Rheumatology, Dokkyo Medical University School of Medicine, Tochigi, Japan | |||||
| 著者所属 | ||||||
| 値 | Department of Rheumatology, Dokkyo Medical University School of Medicine, Tochigi, Japan | |||||
| 著者所属 | ||||||
| 値 | Department of Rheumatology, Dokkyo Medical University School of Medicine, Tochigi, Japan | |||||
| 著者所属 | ||||||
| 値 | Department of Rheumatology, Dokkyo Medical University School of Medicine, Tochigi, Japan | |||||
| 書誌情報 |
Dokkyo Medical Journal 巻 1, 号 4, p. 285-291, 発行日 2022-12 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Objective: To determine whether tumor necrosis factor (TNF) blockade improves small airway obstruction in rheumatoid arthritis (RA) patients without apparent respiratory symptoms. Methods: Pulmonary function tests were performed before and one year after TNF blockade therapy in 29 RA patients without apparent respiratory symptoms. As a control, pulmonary function was examined at a one-year interval in 27 RA patients with conventional disease-modifying antirheumatic drugs (DMARDs) alone. Small airway obstruction was diagnosed when one of maximal mid-expiratory flow rate (MMEF), forced expiratory flow at 50% (FEF50) or 75% (FEF75) of the vital capacity was decreased to less than 60%, 55%, or 45% of predicted values, respectively. Results: Small airway obstruction was found in 62.5% of RA patients. No differences were found in age, sex, disease duration, or disease activities. TNF inhibitors dramatically reduced disease activities. However, TNF inhibitors failed to improve small airway obstructions but worsened them. Conclusions: TNF blockade fails to improve small airway obstruction, suggesting that TNF-independent pathways play important roles in the development of small airway obstruction in RA. |
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| 記事種別 | ||||||
| 値 | Original | |||||
| 出版者 | ||||||
| 出版者 | Dokkyo Medical Society | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2436-522X | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.51040/dkmj.2022-013 | |||||
