| Item type |
学術雑誌論文 / Journal Article(1) |
| タイトル |
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タイトル |
Tumor Necrosis Factor Blockade Fails to Improve Small Airway Obstruction in Rheumatoid Arthritis |
| 言語 |
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言語 |
eng |
| キーワード |
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主題Scheme |
Other |
|
主題 |
rheumatoid arthritis |
| キーワード |
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主題Scheme |
Other |
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主題 |
TNF blockade |
| キーワード |
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主題Scheme |
Other |
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主題 |
small airway disease |
| キーワード |
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主題Scheme |
Other |
|
主題 |
pulmonary function |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Yamazaki, Ryutaro
Kurasawa, Kazuhiro
Nagasawa, Junya
Tanaka, Ayae
Arai, Satoko
Owada, Takayoshi
Arima, Masafumi
Maezawa, Reika
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| 著者所属 |
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Department of Rheumatology, Dokkyo Medical University School of Medicine, Tochigi, Japan |
| 著者所属 |
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Department of Rheumatology, Dokkyo Medical University School of Medicine, Tochigi, Japan |
| 著者所属 |
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Department of Rheumatology, Dokkyo Medical University School of Medicine, Tochigi, Japan |
| 著者所属 |
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Department of Rheumatology, Dokkyo Medical University School of Medicine, Tochigi, Japan |
| 著者所属 |
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Department of Rheumatology, Dokkyo Medical University School of Medicine, Tochigi, Japan |
| 著者所属 |
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Department of Rheumatology, Dokkyo Medical University School of Medicine, Tochigi, Japan |
| 著者所属 |
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Department of Rheumatology, Dokkyo Medical University School of Medicine, Tochigi, Japan |
| 著者所属 |
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Department of Rheumatology, Dokkyo Medical University School of Medicine, Tochigi, Japan |
| 書誌情報 |
Dokkyo Medical Journal
巻 1,
号 4,
p. 285-291,
発行日 2022-12
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Objective: To determine whether tumor necrosis factor (TNF) blockade improves small airway obstruction in rheumatoid arthritis (RA) patients without apparent respiratory symptoms.
Methods: Pulmonary function tests were performed before and one year after TNF blockade therapy in 29 RA patients without apparent respiratory symptoms. As a control, pulmonary function was examined at a one-year interval in 27 RA patients with conventional disease-modifying antirheumatic drugs (DMARDs) alone. Small airway obstruction was diagnosed when one of maximal mid-expiratory flow rate (MMEF), forced expiratory flow at 50% (FEF50) or 75% (FEF75) of the vital capacity was decreased to less than 60%, 55%, or 45% of predicted values, respectively.
Results: Small airway obstruction was found in 62.5% of RA patients. No differences were found in age, sex, disease duration, or disease activities. TNF inhibitors dramatically reduced disease activities. However, TNF inhibitors failed to improve small airway obstructions but worsened them.
Conclusions: TNF blockade fails to improve small airway obstruction, suggesting that TNF-independent pathways play important roles in the development of small airway obstruction in RA. |
| 記事種別 |
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Original |
| 出版者 |
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出版者 |
Dokkyo Medical Society |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
2436-522X |
| DOI |
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識別子タイプ |
DOI |
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関連識別子 |
10.51040/dkmj.2022-013 |
DKMJ-1-4-Yamazaki-Fulltext (128.8 kB)
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