{"_buckets": {"deposit": "e0253087-a1fc-40fe-b450-a3a6f0975beb"}, "_deposit": {"created_by": 3, "id": "656", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "656"}, "status": "published"}, "_oai": {"id": "oai:dmu.repo.nii.ac.jp:00000656", "sets": ["45"]}, "author_link": ["2679"], "item_2_biblio_info_12": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2008-03-01", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "T58", "bibliographicPageStart": "T51", "bibliographicVolumeNumber": "35", "bibliographic_titles": [{"bibliographic_title": "Dokkyo journal of medical sciences"}]}]}, "item_2_description_10": {"attribute_name": "抄録(日)", "attribute_value_mlt": [{"subitem_description": "Ca^\u003c2+\u003e負荷下イソプロテレノール誘発心室細動(Iso-Vf)および虚血再灌流誘発心室細動(Rep-Vf)に対するベンゾチアゼピン誘導体K201およびジルチアゼムの抑制効果を検討した. Wistar雄性ラットを用い,Ca^\u003c2+\u003e負荷(12mg/kg/min) 20分間後イソプロテレノール(0.6μg/kg/分)を20分間投与した.虚血再灌流実験では左冠動脈前下行枝を結紮5分後再灌流した. K201またはジルチアゼム(各々1mg/kg)はイソプロテレノール投与時あるいは冠動脈結紮10分前に1分間で投与した.各実験で心室頻脈および心室細動の発生頻度,出現時間,持続時間,および死亡率を調べた.また,ダブルプロダクト(平均血圧×心拍数)を算出した. Iso-Vfの発生率は対照群5/6 (83.3%),ジルチアゼム群4/6 (66.7%), K201群0/6 (0%)で, K201はIso-Vfを有意に抑制した(p\u003c0.05).虚血再灌流実験ではRep-Vfの発生率は対照群12/14 (85.7%), K201群3/15 (20.0%),ジルチアゼム群3/9 (33.3%)でK201,ジルチアゼムともに有意に抑制した.以上より, K201は著明にIso-VfおよびRep-Vfを抑制したが,ジルチアゼムはIso-Vfを抑制しなかった. Iso-VfおよびRep-Vfともに発生様式からearly afterdepolarization (EAD)が推測され, K201はEADを抑制する可能性が示唆された.", "subitem_description_type": "Other"}]}, "item_2_description_15": {"attribute_name": "表示順", "attribute_value_mlt": [{"subitem_description": "19", "subitem_description_type": "Other"}]}, "item_2_description_16": {"attribute_name": "アクセション番号", "attribute_value_mlt": [{"subitem_description": "KJ00005058760", "subitem_description_type": "Other"}]}, "item_2_description_8": {"attribute_name": "記事種別(日)", "attribute_value_mlt": [{"subitem_description": "学位申請論文", "subitem_description_type": "Other"}]}, "item_2_source_id_1": {"attribute_name": "雑誌書誌ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00629581", "subitem_source_identifier_type": "NCID"}]}, "item_2_source_id_19": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "03855023", "subitem_source_identifier_type": "ISSN"}]}, "item_2_text_6": {"attribute_name": "著者所属(日)", "attribute_value_mlt": [{"subitem_text_value": "獨協医科大学内科学(心血管・肺)"}]}, "item_2_title_3": {"attribute_name": "論文名よみ", "attribute_value_mlt": [{"subitem_title": "シンシツ サイドウ ト ソノ ヨクセイ キジョ ニ カンスル ジッケンテキ ケントウ : ベンゾチアゼピン ユウドウタイ K201 ト ジルチアゼム ノ ヒカク ケントウ"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "大谷, 直由"}, {"creatorName": "オオタニ, ナオユキ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "2679", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-05-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "KJ00005058760.pdf", "filesize": [{"value": "601.0 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 601000.0, "url": {"label": "KJ00005058760.pdf", "url": "https://dmu.repo.nii.ac.jp/record/656/files/KJ00005058760.pdf"}, "version_id": "ea3c4891-0f12-4cc8-b0ea-7855d7d632c7"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "K201", "subitem_subject_scheme": "Other"}, {"subitem_subject": "心室細動", "subitem_subject_scheme": "Other"}, {"subitem_subject": "early afterdepolarization", "subitem_subject_scheme": "Other"}, {"subitem_subject": "ジルチアゼム", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "心室細動とその抑制機序に関する実験的検討 : ベンゾチアゼピン誘導体K201とジルチアゼムの比較検討", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "心室細動とその抑制機序に関する実験的検討 : ベンゾチアゼピン誘導体K201とジルチアゼムの比較検討"}]}, "item_type_id": "2", "owner": "3", "path": ["45"], "permalink_uri": "https://dmu.repo.nii.ac.jp/records/656", "pubdate": {"attribute_name": "公開日", "attribute_value": "2017-05-24"}, "publish_date": "2017-05-24", "publish_status": "0", "recid": "656", "relation": {}, "relation_version_is_last": true, "title": ["心室細動とその抑制機序に関する実験的検討 : ベンゾチアゼピン誘導体K201とジルチアゼムの比較検討"], "weko_shared_id": 3}