{"_buckets": {"deposit": "4cfc6aff-dee4-48f3-a5f0-df53f17cfdcb"}, "_deposit": {"created_by": 3, "id": "764", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "764"}, "status": "published"}, "_oai": {"id": "oai:dmu.repo.nii.ac.jp:00000764", "sets": ["49"]}, "author_link": ["3188"], "item_2_biblio_info_12": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2009-03-25", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "T53", "bibliographicPageStart": "T45", "bibliographicVolumeNumber": "36", "bibliographic_titles": [{"bibliographic_title": "Dokkyo journal of medical sciences"}]}]}, "item_2_description_10": {"attribute_name": "抄録(日)", "attribute_value_mlt": [{"subitem_description": "陳旧性心筋梗塞ラットで,ノルエピネフリン誘発性拡張障害を惹起させ,その発生様式ならびにリアノジン受容体安定化作用を有する1,4-ベンゾチアゼピン誘導体K201の改善作用を調べた.冠動脈結紮10\u0026#12316;13週間後,ノルエピネフリン(20 mg/kg/分)を30分間投与し,K201 投与群(n=5),非投与群(n=5),sham群(n=3)で,心拍数,左室収縮期圧,左室拡張期最小圧,左室拡張末期圧,+dP/dt,-dP/dtを測定した.K201(0.1 mg/kg/分)はノルエピネフリン投与中に10分間投与した.ノルエピネフリン投与により梗塞サイズと左室拡張期最小圧,左室拡張末期圧との間に正相関があり,K201は心拍数,左室収縮期圧,左室拡張期最小圧,左室拡張末期圧を有意に減少させ,非投与群との%変化率でも拡張能を有意に改善させた.以上よりK201は梗塞心におけるノルエピネフリン誘発拡張障害を改善させ,その作用機序としてK201のa 1受容体遮断作用に加えて,リアノジン受容体安定化作用による細胞内Ca2+負荷の改善が示唆された.", "subitem_description_type": "Other"}]}, "item_2_description_15": {"attribute_name": "表示順", "attribute_value_mlt": [{"subitem_description": "18", "subitem_description_type": "Other"}]}, "item_2_description_16": {"attribute_name": "アクセション番号", "attribute_value_mlt": [{"subitem_description": "KJ00006358559", "subitem_description_type": "Other"}]}, "item_2_description_8": {"attribute_name": "記事種別(日)", "attribute_value_mlt": [{"subitem_description": "学位申請論文", "subitem_description_type": "Other"}]}, "item_2_source_id_1": {"attribute_name": "雑誌書誌ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00629581", "subitem_source_identifier_type": "NCID"}]}, "item_2_source_id_19": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "03855023", "subitem_source_identifier_type": "ISSN"}]}, "item_2_text_6": {"attribute_name": "著者所属(日)", "attribute_value_mlt": [{"subitem_text_value": "獨協医科大学内科学(心血管・肺)"}]}, "item_2_title_3": {"attribute_name": "論文名よみ", "attribute_value_mlt": [{"subitem_title": "サシツ カクチョウ ショウガイ ノ ハッセイ ト ソノ ヨボウ ニ カンスル ジッケンテキ ケントウ : ラット チンキュウセイ コウソクシン ニ ヨル ケントウ"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "西野, 節"}, {"creatorName": "ニシノ, セツ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "3188", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-05-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "KJ00006358559.pdf", "filesize": [{"value": "379.3 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 379300.0, "url": {"label": "KJ00006358559.pdf", "url": "https://dmu.repo.nii.ac.jp/record/764/files/KJ00006358559.pdf"}, "version_id": "e38d9869-04bf-4762-a3f1-4ab1219ed789"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "ラット陳旧性心筋梗塞", "subitem_subject_scheme": "Other"}, {"subitem_subject": "ノルエピネフリン", "subitem_subject_scheme": "Other"}, {"subitem_subject": "左室拡張障害", "subitem_subject_scheme": "Other"}, {"subitem_subject": "K201", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "左室拡張障害の発生とその予防に関する実験的検討 : ラット陳旧性梗塞心による検討", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "左室拡張障害の発生とその予防に関する実験的検討 : ラット陳旧性梗塞心による検討"}]}, "item_type_id": "2", "owner": "3", "path": ["49"], "permalink_uri": "https://dmu.repo.nii.ac.jp/records/764", "pubdate": {"attribute_name": "公開日", "attribute_value": "2017-05-24"}, "publish_date": "2017-05-24", "publish_status": "0", "recid": "764", "relation": {}, "relation_version_is_last": true, "title": ["左室拡張障害の発生とその予防に関する実験的検討 : ラット陳旧性梗塞心による検討"], "weko_shared_id": 3}