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  1. Dokkyo Journal of Medical Sciences
  2. 36(3) 2009

Splenomegaly and Tumor Marker Response Following Selective Internal Radiation Therapy for Non-Resectable Liver Metastases from Neuroendocrine Tumor

https://dmu.repo.nii.ac.jp/records/807
https://dmu.repo.nii.ac.jp/records/807
45fd586f-f25b-4d9f-809d-72340e904e50
名前 / ファイル ライセンス アクション
KJ00006364179.pdf KJ00006364179.pdf (64.0 kB)
Item type [ELS]学術雑誌論文 / Journal Article(1)
公開日 2017-05-24
タイトル
タイトル Splenomegaly and Tumor Marker Response Following Selective Internal Radiation Therapy for Non-Resectable Liver Metastases from Neuroendocrine Tumor
言語 en
言語
言語 eng
キーワード
言語 en
主題 internal radiation therapy, SIRT, neuroendocrine tumor, liver metastasis, splenomegaly
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
雑誌書誌ID
収録物識別子 AA00629581
論文名よみ
タイトル Splenomegaly and Tumor Marker Response Following Selective Internal Radiation Therapy for Non-Resectable Liver Metastases from Neuroendocrine Tumor
著者 Shehata, Mena

× Shehata, Mena

en Shehata, Mena

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Yan, Kenneth

× Yan, Kenneth

en Yan, Kenneth

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Itoh, Seiji

× Itoh, Seiji

en Itoh, Seiji

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King, Julie

× King, Julie

en King, Julie

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Glenn, Derek

× Glenn, Derek

en Glenn, Derek

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Quinn, Richard

× Quinn, Richard

en Quinn, Richard

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Morris, David Lawson

× Morris, David Lawson

en Morris, David Lawson

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著者所属(英)
en
Department of Surgery, St. George Hospital, University of New South Wales, Sydney, Australia
著者所属(英)
en
Department of Surgery, St. George Hospital, University of New South Wales, Sydney, Australia
著者所属(英)
en
Department of Surgery, St. George Hospital, University of New South Wales, Sydney, Australia:Department of Surgery, Teishinkai Hospitals, Ibaraki, Japan
著者所属(英)
en
Department of Surgery, St. George Hospital, University of New South Wales, Sydney, Australia
著者所属(英)
en
Department of Surgery, St. George Hospital, University of New South Wales, Sydney, Australia
著者所属(英)
en
Department of Surgery, St. George Hospital, University of New South Wales, Sydney, Australia
著者所属(英)
en
Department of Surgery, St. George Hospital, University of New South Wales, Sydney, Australia
記事種別(英)
内容記述タイプ Other
内容記述 Original
抄録(英)
内容記述タイプ Other
内容記述 PURPOSE:The aim of this study was to investigate changes in spleen size, the level of chromogranin Aas a tumor marker, and the relationship between these two parameters before and 3 months after selectiveinternal radiation therapy (SIRT) for non-resectable liver metastases from neuroendocrine tumor (NET).Our first serious adverse event with this relatively new treatment is also discussed.METHODS:A retrospective review of a prospective database identified patients with non-resectable livermetastases from NET who underwent SIRT between 2003 and 2007. Patients who underwent CT scansbefore and 3 months after treatment were included. The patients were divided into two groups:those withand without a 20 % or more increase in splenic volume on the CT scans. The percentages of patients showinga tumor marker response in the two groups were then comparedRESULTS:Fourteen patients were included in the present analysis. A tumor marker response was seenin 6 of 7 patients( 85.7%) who showed an increase in splenic volume of>20%, and in 3 of 7 patients( 42.9%) without an increase in splenic volume (p=0.266). There was one death as a result of oesophageal varicealbleeding due to portal hypertension at 9 months after treatment.CONCLUSION:Splenic enlargement after SIRT may be associated with tumor marker response, althoughthis could not be confirmed statistically in this study due to the small number of patients. Long-termsplenomegaly and portal hypertension may be important complications of SIRT. This issue needs to be investigatedfurther using a larger number of patients and longer follow-up.
書誌情報 Dokkyo journal of medical sciences

巻 36, 号 3, p. 131-134, 発行日 2009-10-25
ISSN
収録物識別子タイプ ISSN
収録物識別子 03855023
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