| Item type |
[ELS]学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-05-24 |
| タイトル |
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タイトル |
Splenomegaly and Tumor Marker Response Following Selective Internal Radiation Therapy for Non-Resectable Liver Metastases from Neuroendocrine Tumor |
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言語 |
en |
| 言語 |
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言語 |
eng |
| キーワード |
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言語 |
en |
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主題 |
internal radiation therapy, SIRT, neuroendocrine tumor, liver metastasis, splenomegaly |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 雑誌書誌ID |
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収録物識別子 |
AA00629581 |
| 論文名よみ |
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タイトル |
Splenomegaly and Tumor Marker Response Following Selective Internal Radiation Therapy for Non-Resectable Liver Metastases from Neuroendocrine Tumor |
| 著者 |
Shehata, Mena
Yan, Kenneth
Itoh, Seiji
King, Julie
Glenn, Derek
Quinn, Richard
Morris, David Lawson
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| 著者所属(英) |
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en |
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Department of Surgery, St. George Hospital, University of New South Wales, Sydney, Australia |
| 著者所属(英) |
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en |
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Department of Surgery, St. George Hospital, University of New South Wales, Sydney, Australia |
| 著者所属(英) |
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en |
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Department of Surgery, St. George Hospital, University of New South Wales, Sydney, Australia:Department of Surgery, Teishinkai Hospitals, Ibaraki, Japan |
| 著者所属(英) |
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en |
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Department of Surgery, St. George Hospital, University of New South Wales, Sydney, Australia |
| 著者所属(英) |
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en |
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Department of Surgery, St. George Hospital, University of New South Wales, Sydney, Australia |
| 著者所属(英) |
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en |
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Department of Surgery, St. George Hospital, University of New South Wales, Sydney, Australia |
| 著者所属(英) |
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en |
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Department of Surgery, St. George Hospital, University of New South Wales, Sydney, Australia |
| 記事種別(英) |
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内容記述タイプ |
Other |
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内容記述 |
Original |
| 抄録(英) |
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内容記述タイプ |
Other |
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内容記述 |
PURPOSE:The aim of this study was to investigate changes in spleen size, the level of chromogranin Aas a tumor marker, and the relationship between these two parameters before and 3 months after selectiveinternal radiation therapy (SIRT) for non-resectable liver metastases from neuroendocrine tumor (NET).Our first serious adverse event with this relatively new treatment is also discussed.METHODS:A retrospective review of a prospective database identified patients with non-resectable livermetastases from NET who underwent SIRT between 2003 and 2007. Patients who underwent CT scansbefore and 3 months after treatment were included. The patients were divided into two groups:those withand without a 20 % or more increase in splenic volume on the CT scans. The percentages of patients showinga tumor marker response in the two groups were then comparedRESULTS:Fourteen patients were included in the present analysis. A tumor marker response was seenin 6 of 7 patients( 85.7%) who showed an increase in splenic volume of>20%, and in 3 of 7 patients( 42.9%) without an increase in splenic volume (p=0.266). There was one death as a result of oesophageal varicealbleeding due to portal hypertension at 9 months after treatment.CONCLUSION:Splenic enlargement after SIRT may be associated with tumor marker response, althoughthis could not be confirmed statistically in this study due to the small number of patients. Long-termsplenomegaly and portal hypertension may be important complications of SIRT. This issue needs to be investigatedfurther using a larger number of patients and longer follow-up. |
| 書誌情報 |
Dokkyo journal of medical sciences
巻 36,
号 3,
p. 131-134,
発行日 2009-10-25
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
03855023 |
KJ00006364179.pdf (64.0 kB)
