{"_buckets": {"deposit": "91a0f372-7105-4a78-9d71-428167bc61d2"}, "_deposit": {"created_by": 3, "id": "998", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "998"}, "status": "published"}, "_oai": {"id": "oai:dmu.repo.nii.ac.jp:00000998", "sets": ["61"]}, "author_link": ["4645", "4647", "4648", "4643", "4644", "4646"], "item_2_biblio_info_12": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2012-03-25", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "43", "bibliographicPageStart": "37", "bibliographicVolumeNumber": "39", "bibliographic_titles": [{"bibliographic_title": "Dokkyo journal of medical sciences"}]}]}, "item_2_description_10": {"attribute_name": "抄録(日)", "attribute_value_mlt": [{"subitem_description": "Apo-E KO マウス( ApoE-/-) を用いて,コレステロール吸収阻害薬のezetimibe( EZ) とHMG-CoAreductase 阻害薬のfluvastatin( Fluva) の動脈硬化形成に与える影響について検討した.高脂肪食負荷ApoE-/- マウスではEZ の投与により,総コレステロールおよびLDL コレステロールをそれぞれ63%,74%減少させ,胸部大動脈のプラーク形成を明らかに抑制するとともに,内皮依存性の血管弛緩反応を有意に改善した.一方,Fluva 投与ではその効果が認められなかった.また,EZ 投与はmonocyte chemoattractantprotein-1,vascular cell adhesion molecule-1,intercellular adhesion molecule-1 などの白血球走化・接着因子やNADPH oxidase コンポーネントの肺組織中mRNA 発現を有意に抑制した.高脂肪食負荷ApoE-/- マウスにおいて,EZ は明らかな抗動脈硬化作用を示した.", "subitem_description_type": "Other"}]}, "item_2_description_11": {"attribute_name": "抄録(英)", "attribute_value_mlt": [{"subitem_description": "The aim of present study was to investigate the effects ofezetimibe, a cholesterol absorption inhibitor, on athrosclerosisin apolipoprotein E knockout (ApoE-KO) mice. Tretmentwith ezetimibe, but not fluvastatin, significantly Decreased serum total and low density lipoprotein (LDL)Cholesterol and lesions of atherosclerotic plaque of aorta Inwastern diet-fed ApoE-KO mice. Ezetimibe also restorednitric oxide-mediated vascular relaxation in isolated aorticrings.Moreover, ezetimibe treatment significantly decreased the mRNA expression of a chemoattractant, adhesion molecules,and several subunits of NADPH oxidase in lung tissues.These results suggest that ezetimibe may inhibit athrosclerosis by ameliorating vascular inflammation and oxidative stress in ApoE-KO mice independently of lowering serum cholesterol level.", "subitem_description_type": "Other"}]}, "item_2_description_15": {"attribute_name": "表示順", "attribute_value_mlt": [{"subitem_description": "6", "subitem_description_type": "Other"}]}, "item_2_description_16": {"attribute_name": "アクセション番号", "attribute_value_mlt": [{"subitem_description": "KJ00007846059", "subitem_description_type": "Other"}]}, "item_2_description_8": {"attribute_name": "記事種別(日)", "attribute_value_mlt": [{"subitem_description": "原著", "subitem_description_type": "Other"}]}, "item_2_source_id_1": {"attribute_name": "雑誌書誌ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00629581", "subitem_source_identifier_type": "NCID"}]}, "item_2_source_id_19": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "03855023", "subitem_source_identifier_type": "ISSN"}]}, "item_2_text_6": {"attribute_name": "著者所属(日)", "attribute_value_mlt": [{"subitem_text_value": "獨協医科大学内科学(内分泌代謝)"}, {"subitem_text_value": "獨協医科大学薬理学"}, {"subitem_text_value": "獨協医科大学内科学(内分泌代謝) "}]}, "item_2_text_7": {"attribute_name": "著者所属(英)", "attribute_value_mlt": [{"subitem_text_language": "en", "subitem_text_value": "Department of Endocrinology and Metabolism, Dokkyo Medical University School of Medicine."}, {"subitem_text_language": "en", "subitem_text_value": "Department of Pharmacology, Dokkyo Medical University School of Medicine."}, {"subitem_text_language": "en", "subitem_text_value": "Department of Endocrinology and Metabolism, Dokkyo Medical University School of Medicine."}]}, "item_2_title_3": {"attribute_name": "論文名よみ", "attribute_value_mlt": [{"subitem_title": "Apo-E KO( ApoE-/-) マウス ニオケル Ezetimibe ノ コウ ドウミャク コウカ サヨウ"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "助川, 敦子"}, {"creatorName": "スケガワ, アツコ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "4643", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "内田, 幸介"}, {"creatorName": "ウチダ, コウスケ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "4644", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "城島, 輝雄"}, {"creatorName": "ジョウジマ, テルオ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "4645", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sukegawa, Atsuko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "4646", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Uchida, Kosuke", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "4647", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Jojima, Teruo", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "4648", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-05-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "KJ00007846059.pdf", "filesize": [{"value": "400.0 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 400000.0, "url": {"label": "KJ00007846059.pdf", "url": "https://dmu.repo.nii.ac.jp/record/998/files/KJ00007846059.pdf"}, "version_id": "b9e95e77-5ba0-4efc-be04-5dea811b9636"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "エゼチミブ", "subitem_subject_scheme": "Other"}, {"subitem_subject": "抗動脈硬化作用", "subitem_subject_scheme": "Other"}, {"subitem_subject": "高脂肪食APO-E KO (ApoE-/-) マウス", "subitem_subject_scheme": "Other"}, {"subitem_subject": "酸化ストレス", "subitem_subject_scheme": "Other"}, {"subitem_subject": "血管内皮障害", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Apo-E KO( ApoE-/-) マウスにおけるEzetimibe の抗動脈硬化作用", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Apo-E KO( ApoE-/-) マウスにおけるEzetimibe の抗動脈硬化作用"}, {"subitem_title": "Anti-Atherogenic Effect of Eztimibe in Apo-E Knockout Mice", "subitem_title_language": "en"}]}, "item_type_id": "2", "owner": "3", "path": ["61"], "permalink_uri": "https://dmu.repo.nii.ac.jp/records/998", "pubdate": {"attribute_name": "公開日", "attribute_value": "2017-05-24"}, "publish_date": "2017-05-24", "publish_status": "0", "recid": "998", "relation": {}, "relation_version_is_last": true, "title": ["Apo-E KO( ApoE-/-) マウスにおけるEzetimibe の抗動脈硬化作用"], "weko_shared_id": 3}