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  1. Dokkyo Journal of Medical Sciences
  2. 39(1) 2012

Apo-E KO( ApoE-/-) マウスにおけるEzetimibe の抗動脈硬化作用

https://dmu.repo.nii.ac.jp/records/998
https://dmu.repo.nii.ac.jp/records/998
a7b98833-e52b-4c44-8926-bdbd61445401
名前 / ファイル ライセンス アクション
KJ00007846059.pdf KJ00007846059.pdf (400.0 kB)
Item type [ELS]学術雑誌論文 / Journal Article(1)
公開日 2017-05-24
タイトル
タイトル Apo-E KO( ApoE-/-) マウスにおけるEzetimibe の抗動脈硬化作用
タイトル
言語 en
タイトル Anti-Atherogenic Effect of Eztimibe in Apo-E Knockout Mice
言語
言語 jpn
キーワード
主題 エゼチミブ
キーワード
主題 抗動脈硬化作用
キーワード
主題 高脂肪食APO-E KO (ApoE-/-) マウス
キーワード
主題 酸化ストレス
キーワード
主題 血管内皮障害
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
雑誌書誌ID
収録物識別子 AA00629581
論文名よみ
タイトル Apo-E KO( ApoE-/-) マウス ニオケル Ezetimibe ノ コウ ドウミャク コウカ サヨウ
著者 助川, 敦子

× 助川, 敦子

WEKO 4643

助川, 敦子

ja-Kana スケガワ, アツコ

Search repository
内田, 幸介

× 内田, 幸介

WEKO 4644

内田, 幸介

ja-Kana ウチダ, コウスケ

Search repository
城島, 輝雄

× 城島, 輝雄

WEKO 4645

城島, 輝雄

ja-Kana ジョウジマ, テルオ

Search repository
Sukegawa, Atsuko

× Sukegawa, Atsuko

WEKO 4646

en Sukegawa, Atsuko

Search repository
Uchida, Kosuke

× Uchida, Kosuke

WEKO 4647

en Uchida, Kosuke

Search repository
Jojima, Teruo

× Jojima, Teruo

WEKO 4648

en Jojima, Teruo

Search repository
著者所属(日)
獨協医科大学内科学(内分泌代謝)
著者所属(日)
獨協医科大学薬理学
著者所属(日)
獨協医科大学内科学(内分泌代謝)
著者所属(英)
en
Department of Endocrinology and Metabolism, Dokkyo Medical University School of Medicine.
著者所属(英)
en
Department of Pharmacology, Dokkyo Medical University School of Medicine.
著者所属(英)
en
Department of Endocrinology and Metabolism, Dokkyo Medical University School of Medicine.
記事種別(日)
内容記述タイプ Other
内容記述 原著
抄録(日)
内容記述タイプ Other
内容記述 Apo-E KO マウス( ApoE-/-) を用いて,コレステロール吸収阻害薬のezetimibe( EZ) とHMG-CoAreductase 阻害薬のfluvastatin( Fluva) の動脈硬化形成に与える影響について検討した.高脂肪食負荷ApoE-/- マウスではEZ の投与により,総コレステロールおよびLDL コレステロールをそれぞれ63%,74%減少させ,胸部大動脈のプラーク形成を明らかに抑制するとともに,内皮依存性の血管弛緩反応を有意に改善した.一方,Fluva 投与ではその効果が認められなかった.また,EZ 投与はmonocyte chemoattractantprotein-1,vascular cell adhesion molecule-1,intercellular adhesion molecule-1 などの白血球走化・接着因子やNADPH oxidase コンポーネントの肺組織中mRNA 発現を有意に抑制した.高脂肪食負荷ApoE-/- マウスにおいて,EZ は明らかな抗動脈硬化作用を示した.
抄録(英)
内容記述タイプ Other
内容記述 The aim of present study was to investigate the effects ofezetimibe, a cholesterol absorption inhibitor, on athrosclerosisin apolipoprotein E knockout (ApoE-KO) mice. Tretmentwith ezetimibe, but not fluvastatin, significantly Decreased serum total and low density lipoprotein (LDL)Cholesterol and lesions of atherosclerotic plaque of aorta Inwastern diet-fed ApoE-KO mice. Ezetimibe also restorednitric oxide-mediated vascular relaxation in isolated aorticrings.Moreover, ezetimibe treatment significantly decreased the mRNA expression of a chemoattractant, adhesion molecules,and several subunits of NADPH oxidase in lung tissues.These results suggest that ezetimibe may inhibit athrosclerosis by ameliorating vascular inflammation and oxidative stress in ApoE-KO mice independently of lowering serum cholesterol level.
書誌情報 Dokkyo journal of medical sciences

巻 39, 号 1, p. 37-43, 発行日 2012-03-25
ISSN
収録物識別子 03855023
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