{"_buckets": {"deposit": "c2a66a0a-324e-4ee4-af4b-83734d59058c"}, "_deposit": {"created_by": 3, "id": "1090", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "1090"}, "status": "published"}, "_oai": {"id": "oai:dmu.repo.nii.ac.jp:00001090", "sets": ["65"]}, "author_link": ["5150"], "item_2_biblio_info_12": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2013-03-25", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "T22", "bibliographicPageStart": "T13", "bibliographicVolumeNumber": "40", "bibliographic_titles": [{"bibliographic_title": "Dokkyo journal of medical sciences"}]}]}, "item_2_description_10": {"attribute_name": "抄録(日)", "attribute_value_mlt": [{"subitem_description": "ヒト循環血中の樹状細胞( DC)にはmyeloid DC( mDC)とplasmacytoid DC( pDC) の2つの主要なサブセットが存在し,mDC は,Th1 を誘導するmDC1 と,Th2 を誘導するmDC2 に分けられる.本研究では,Th1疾患であるサルコイドーシス( サ症)( n=30)とTh2疾患であるアトピー性疾患( n=23)における末梢血DC サブセットを,健常人 (n=23)と比較して検討した.フローサイトメトリーを用いて末梢血中のmDC(CD11c+),pDC( CD123+),mDC1( CD1a+),mDC2( CD141+)のサブセット解析を行った.サ症群では総DC, mDC の数が有意に低下していた.mDC/pDC 比は3 群間で差がなかった.CD1a+mDC は,サ症群では対照群と差がなかったが,アトピー群ではCD1a+mDC の減少,CD1a\u0026#8722;mDC の増加を認め,CD1a+/CD1a\u0026#8722;mDC比は小さかった.CD141+mDC はアトピー群で有意に増加していたが,CD141\u0026#8722;mDC 数は3 群間で有意差はなかった.CD141\u0026#8722;/CD141+mDC 比はアトピー群で有意に低値であった.アトピー群では,CD1a+mDC の減少とCD141+mDC の増加を認め,末梢血中DC の動態がTh2 への偏倚を反映するものと考えられた.サ症では,DC 数は減少し,その動態からはTh1/Th2 の偏倚は明確でなく,肺などの病変局所に集積したDC を用いた解析が必要と考えられた.", "subitem_description_type": "Other"}]}, "item_2_description_15": {"attribute_name": "表示順", "attribute_value_mlt": [{"subitem_description": "13", "subitem_description_type": "Other"}]}, "item_2_description_16": {"attribute_name": "アクセション番号", "attribute_value_mlt": [{"subitem_description": "KJ00008419740", "subitem_description_type": "Other"}]}, "item_2_description_8": {"attribute_name": "記事種別(日)", "attribute_value_mlt": [{"subitem_description": "学位申請論文", "subitem_description_type": "Other"}]}, "item_2_source_id_1": {"attribute_name": "雑誌書誌ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00629581", "subitem_source_identifier_type": "NCID"}]}, "item_2_source_id_19": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "03855023", "subitem_source_identifier_type": "ISSN"}]}, "item_2_text_6": {"attribute_name": "著者所属(日)", "attribute_value_mlt": [{"subitem_text_value": "獨協医科大学内科学(呼吸器・アレルギー)"}]}, "item_2_title_3": {"attribute_name": "論文名よみ", "attribute_value_mlt": [{"subitem_title": "Th1/Th2 カンレン シッカン ニオケル マッショウ ケツ ジュジョウ サイボウ サブセット ノ カイセキ"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "林, ゆめ子"}, {"creatorName": "ハヤシ, ユメコ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "5150", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-05-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "KJ00008419740.pdf", "filesize": [{"value": "1.1 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1100000.0, "url": {"label": "KJ00008419740.pdf", "url": "https://dmu.repo.nii.ac.jp/record/1090/files/KJ00008419740.pdf"}, "version_id": "ab40aa69-98f1-4815-bc0a-615d8473dde5"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "樹状細胞", "subitem_subject_scheme": "Other"}, {"subitem_subject": "ヒト末梢血", "subitem_subject_scheme": "Other"}, {"subitem_subject": "myeloid DC", "subitem_subject_scheme": "Other"}, {"subitem_subject": "CD1a", "subitem_subject_scheme": "Other"}, {"subitem_subject": "CD141", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Th1/Th2 関連疾患における末梢血樹状細胞サブセットの解析", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Th1/Th2 関連疾患における末梢血樹状細胞サブセットの解析"}]}, "item_type_id": "2", "owner": "3", "path": ["65"], "permalink_uri": "https://dmu.repo.nii.ac.jp/records/1090", "pubdate": {"attribute_name": "公開日", "attribute_value": "2017-05-24"}, "publish_date": "2017-05-24", "publish_status": "0", "recid": "1090", "relation": {}, "relation_version_is_last": true, "title": ["Th1/Th2 関連疾患における末梢血樹状細胞サブセットの解析"], "weko_shared_id": 3}